Results 111 to 120 of about 2,610,317 (379)

IL-38 regulates intestinal stem cell homeostasis by inducing WNT signaling and beneficial IL-1β secretion [PDF]

, 2023
Alberto Dinarello, Makenna May, Jesús Amo‐Aparicio, Tania Azam, Joseph M. Gaballa, Carlo Marchetti, Annachiara Tesoriere, Rachele Ghirardo, Jasmina S. Redzic, W. R. Webber, Shaikh M. Atif, Suzhao Li, Elan Eisenmesser, Dennis M. de Graaf, Charles A. Dinarello   +14 more
openalex   +1 more source

The exosome-like vesicles from osteoarthritic chondrocyte enhanced mature IL-1β production of macrophages and aggravated synovitis in osteoarthritis

Cell Death and Disease, 2019
Synovitis, a common clinical symptom for osteoarthritis (OA) patients, is highly related to OA pathological progression and pain manifestation. The activated synovial macrophages have been demonstrated to play an important role in synovitis, but the ...
Z. Ni, L. Kuang, Hangang Chen, Yangli Xie, Bin Zhang, Junjie Ouyang, Jiangyi Wu, Siru Zhou, Liang Chen, Nan Su, Q. Tan, Xiaoqing Luo, Bo Chen, Shuai Chen, L. Yin, Haiyang Huang, Xiaolan Du, Lin Chen   +17 more
semanticscholar   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Interference of Interleukin-1β Mediated by Lentivirus Promotes Functional Recovery of Spinal Cord Contusion Injury in Rats via the PI3K/AKT1 Signaling Pathway

Mediators of Inflammation, 2022
Purpose. Inflammation and apoptosis after spinal cord contusion (SCC) are important causes of irreversible spinal cord injury. Interleukin-1β (IL-1β) is a key inflammatory factor that promotes the aggravation of spinal cord contusion.
Jun-Feng Cao, Xi Hu, Li Xiong, Mei Wu, Xingyu Yang, Chaochao Wang, Shengyan Chen, Hengxiang Xu, Huanyu Chen, Xuntai Ma, Yongjie Mi, Xiao Zhang   +11 more
doaj   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

A balanced IL-1β activity is required for host response to Citrobacter rodentium infection. [PDF]

PLoS ONE, 2013
Microbial sensing plays essential roles in the innate immune response to pathogens. In particular, NLRP3 forms a multiprotein inflammasome complex responsible for the maturation of interleukin (IL)-1β.
Misagh Alipour, Yuefei Lou, Daniel Zimmerman, Michael W Bording-Jorgensen, Consolato Sergi, Julia J Liu, Eytan Wine   +6 more
doaj   +1 more source

Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation [PDF]

, 2017
The NLRP3 inflammasome senses a variety of signals referred to as danger associated molecular patterns (DAMPs), including those triggered by crystalline particulates or degradation products of extracellular matrix. Since some DAMPs confer tissue-specific
Abu-Amer, Yousef, Alippe, Yael, Civitelli, Roberto, Mbalaviele, Gabriel, Novack, Deborah V, Qu, Chao, Ricci, Biancamaria, Wang, Chun, Xiao, Jianqiu, Zou, Wei   +9 more
core   +2 more sources

Additional file 1: Table S1. of P2X7 receptor mediates NLRP3-dependent IL-1β secretion and parasite proliferation in Toxoplasma gondii-infected human small intestinal epithelial cells

, 2018
Sequences of the primers used in this study. (DOC 32 kb)
Quan, Juan-Hua, Huang, Rui, Wang, Zhuang, Huang, Shuai, Choi, In-Wook, Zhou, Yu, Lee, Young-Ha, Chu, Jia-Qi   +7 more
openaire   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Interleukin-1β promotes interleulin-6 expression via ERK1/2 signaling pathway in canine dermal fibroblasts.

PLoS ONE, 2019
Interleukin-6 (IL-6) is a pleiotropic cytokine involved in the regulation of the immune response and inflammation. In this study, we investigated effect of the proinflammatory cytokine interleukin-1β (IL-1β) on IL-6 expression in canine dermal ...
Nanako Kitanaka, Rei Nakano, Kanae Sugiura, Taku Kitanaka, Shinichi Namba, Tadayoshi Konno, Tomohiro Nakayama, Hiroshi Sugiya   +7 more
doaj   +1 more source