Results 131 to 140 of about 3,308,702 (244)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
, 2019 Mice were injected intraperitoneally with 0.5 mg neutralizing antibody or isotype control antibody one day prior to intradermal ear injection with L. major (Lm) or L. major and S. aureus (L+S).
Corey P. Parlet (785839) +14 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Genes differentially expressed in DHA plus IL-1β versus IL-1β-treated cells.
, 2015 F.C. = fold change; U.F. = Genes of unknown function.Genes regulated antagonistically with IL-1β.Genes differentially expressed in DHA plus IL-1β versus IL-1β-treated cells.
Valentina Gatta (139984) +10 more
core +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
IL-1β induces the activation of canonical NF-κB pathway.
, 2018 Canine melanoma cells were exposed to 100 pM IL-1β for the indicated time periods. At the end of the incubation, total (t-) IκBα, β-actin, total (t-) and phosphorylated (p-) forms of p65 and p105 were detected by immunoblotting.
Taku Kitanaka (3350276) +6 more
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
IL-1β-induced cellular migration in dermal fibroblasts.
, 2019 (a, b) After the pretreatment with (open and closed square) or without (open and closed circle) the MMP-3 inhibitor UK356618 (2 μM) for 2 h, the cells were incubated with (closed circle and square) or without (open circle and square) 100 pM IL-1β for ...
Taku Kitanaka (3350276) +7 more
core +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
DHA suppresses inflammasome induced IL-1β production.
, 2014 LPS primed. (A) THP-1 cells and (B) BMDMs were stimulated with ATP. DHA (50 uM or 100 uM) added or not at the priming step. Supernatants were collected and an ELISA was performed to check IL-1β levels.
Cedric Boularan (269965) +6 more
core +1 more source