Results 151 to 160 of about 6,778,674 (329)
IL-1β mRNA expression is elevated in HG mixed glia.
, 2022 The mRNA levels of IL-1β, IL-6, and TNF α in NG and HG mixed glia cultures were quantified by real-time RT PCR. NG, 5.5 mM glucose-containing media; HG, 25 mM glucose-containing media. Data is expressed as mean ± SEM.
Meng An Chien (11993873) +9 more
core +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Genes differentially expressed between IL-1β and ctrl, COT IL-1β and IL-1β, COT and ctrl conditions.
, 2016 Genes differentially expressed between IL-1β and ctrl, COT IL-1β and IL-1β, COT and ctrl conditions.
Samuel Serisier (554865) +6 more
core +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Cell Reports, 2017 LPS-activated macrophages undergo a metabolic shift from dependence on mitochondria-produced ATP to reliance on aerobic glycolysis, where PKM2 is a critical determinant.
Fang Wang +12 more
semanticscholar +1 more source
Polyene macrolide antifungal drugs trigger interleukin-1β secretion by activating the NLRP3 inflammasome. [PDF]
, 2011 The use of antimycotic drugs in fungal infections is based on the concept that they suppress fungal growth by a direct killing effect. However, amphotericin and nystatin have been reported to also trigger interleukin-1β (IL-1β) secretion in monocytes but
Rupanagudi Khader Valli +15 more
core +2 more sources
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
B cells enhance IL-1 beta driven invasiveness in triple negative breast cancer
Scientific ReportsTriple-negative breast cancer (TNBC) is an aggressive subtype often characterized by high lymphocyte infiltration, including tumor-infiltrating B cells (TIBs). These cells are present even in early stages of TNBC and associated with microinvasion.
Nicole J. Toney +7 more
doaj +1 more source
C/EBPβ Acts Upstream of NF-κB P65 Subunit in Ox-LDL-Induced IL-1β Production by Macrophages
Cellular Physiology and Biochemistry, 2018 Background/Aims: Interleukin-1β (IL-1β) is one of the critical inflammatory factors during atherogenesis. CCAAT/enhancer binding proteins β (C/EBPβ), a regulator of IL-1β production, recently been evidenced as a key player in the development of ...
Jun Ma +7 more
doaj +1 more source
IL-1β and OPN mRNA expression in RSV infected cells.
, 2018 HEp-2 and HEK-293 cells were mock infected or infected with 1 MOI of RSV-L19F. RNA was isolated at 24, 48 and 72 hpi. (A-C) Expression levels of RSV-N, IL-1β and OPN were determined by qPCR. Results are presented as fold-change in expression of RSV-N, IL-
Michael B. Cheung (3190440) +5 more
core +1 more source