Results 161 to 170 of about 6,778,674 (329)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

IFN-gamma impairs release of IL-8 by IL-1beta-stimulated A549 lung carcinoma cells [PDF]

, 2008
Background Production of interferon (IFN)-gamma is key to efficient anti-tumor immunity. The present study was set out to investigate effects of IFNgamma on the release of the potent pro-angiogenic mediator IL-8 by human A549 lung carcinoma cells ...
Bernhard Zwissler, Zwißler, Bernhard, Sadik, Christian David, Pfeilschifter, Josef (Prof. Dr.), Heiko Mühl, Malte Bachmann, Muehl, Heiko, Sadik, Christian D., Josef Pfeilschifter, Christian D Sadik, Pfeilschifter, Josef, Bachmann, Malte, Boost, Kim Alexander, Mühl, Heiko, Kim A Boost, Boost, Kim A.   +15 more
core   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

IL-4 Inhibits IL-1β-Induced Depressive-Like Behavior and Central Neurotransmitter Alterations

Mediators of Inflammation, 2015
It has been known that activation of the central innate immune system or exposure to stress can disrupt balance of anti-/proinflammatory cytokines. The aim of the present study was to investigate the role of pro- and anti-inflammatory cytokines in the ...
Hyun-Jung Park, Hyun-Soo Shim, Kyungeh An, Angela Starkweather, Kyung Soo Kim, Insop Shim   +5 more
doaj   +1 more source

The Role of NLRP3 and IL-1β in the Pathogenesis of Inflammatory Bowel Disease

Frontiers in Immunology, 2018
It is logical to assume that a major pro-inflammatory mechanism, i.e., the NLRP3 inflammasome would play a prominent role in the pathogenesis of the Inflammatory Bowel Disease (IBD) in humans.
Liming Mao, A. Kitani, W. Strober, I. Fuss   +3 more
semanticscholar   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Human Innate Immunity to Toxoplasma gondii Is Mediated by Host Caspase-1 and ASC and Parasite GRA15

mBio, 2013
Interleukin-1β (IL-1β) functions as a key regulator of inflammation and innate immunity. The protozoan parasite Toxoplasma gondii actively infects human blood monocytes and induces the production of IL-1β; however, the host and parasite factors that ...
Lanny Gov, Alborz Karimzadeh, Norikiyo Ueno, Melissa B. Lodoen   +3 more
doaj   +1 more source

The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation.

Cell Reports, 2018
Intrinsic apoptosis resulting from BAX/BAK-mediated mitochondrial membrane damage is regarded as immunologically silent. We show here that in macrophages, BAX/BAK activation results in inhibitor of apoptosis (IAP) protein degradation to promote caspase-8-
J. Vince, D. De Nardo, Wenqing Gao, Angelina J. Vince, Cathrine M. Hall, K. McArthur, Daniel S. Simpson, S. Vijayaraj, L. Lindqvist, P. Bouillet, M. A. Rizzacasa, S. Man, J. Silke, S. Masters, G. Lessene, D. Huang, D. Gray, B. Kile, F. Shao, K. Lawlor   +19 more
semanticscholar   +1 more source

Effects of dialyzer membrane on interleukin-1β (IL-1β) and IL-1β—converting enzyme in mononuclear cells [PDF]

, 2001
Effects of dialyzer membrane on interleukin-1β (IL-1β) and IL-1β—converting enzyme in mononuclear cells.BackgroundIn vitro stimulation of mononuclear cells (peripheral blood mononuclear cells; PBMCs) with an endotoxin (lipopolysaccharide; LPS) revealed ...
Lonnemann, Gerhard, Linnenweber, Silvia
core   +1 more source