Results 121 to 130 of about 6,778,674 (329)

CARD9+ Microglia Promote Antifungal Immunity via IL-1β and CXCL1-mediated Neutrophil Recruitment

Nature Immunology, 2019
The C-type lectin receptor–Syk (spleen tyrosine kinase) adaptor CARD9 facilitates protective antifungal immunity within the central nervous system (CNS), as human deficiency in CARD9 causes susceptibility to fungus-specific, CNS-targeted infection. CARD9
Rebecca A. Drummond, M. Swamydas, Vasileios Oikonomou, B. Zhai, I. Dambuza, B. Schaefer, Andrea C. Bohrer, K. Mayer-Barber, S. Lira, Y. Iwakura, S. Filler, Gordon D. Brown, B. Hube, J. Naglik, T. Hohl, M. Lionakis   +15 more
semanticscholar   +1 more source

IL-1β secretion profile.

, 2018
Concentrations of IL-1β (average and range) present in supernatants of Al(OH)3 or DTaP-stimulated THP-1 cells in the absence or presence of Glybenclamide. Data are from three individual experiments, with two technical replicates.
Jeroen L. A. Pennings (224558), Albert J. R. Heck (9680), Gideon F. A. Kersten (543375), Bernard Metz (618308), Cécile A. C. M. van Els (358393), Elly van Riet (618307), Sietske Kooijman (5309417), Fabio Marino (1405816), Hugo D. Meiring (796644), Jolanda Brummelman (618304)   +9 more
core   +1 more source

Evolving concurrent Petri net models of epistasis [PDF]

, 2010
A genetic algorithm is used to learn a non-deterministic Petri netbased model of non-linear gene interactions, or statistical epistasis. Petri nets are computational models of concurrent processes.
Beretta, Lorenzo, Mayo, Michael
core   +1 more source

Pro-IL-1β is expressed at similar levels in ArpC2 Flox and iKO cells.

, 2023
Mouse fibroblasts were treated with DMSO (Flox) or 4-OHT (iKO) for 6d and collected at 9d. Samples were lysed, subjected to SDS-PAGE, and immunoblotted with antibodies to IL-1β, tubulin, actin, and GAPDH. Pro-IL-1β densitometry values are shown.
Shirley Guo (14515841), Elena L. Haarer (14515835), Corey J. Theodore (14515838), Kenneth G. Campellone (7921649), Ryan B. Frier (14515844)   +4 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Salmonella manipulates the host to drive pathogenicity via induction of interleukin 1β.

PLoS Biology
Acute gastrointestinal infection with intracellular pathogens like Salmonella Typhimurium triggers the release of the proinflammatory cytokine interleukin 1β (IL-1β).
Mor Zigdon, Jasmin Sawaed, Lilach Zelik, Dana Binyamin, Shira Ben-Simon, Nofar Asulin, Rachel Levin, Sonia Modilevsky, Maria Naama, Shahar Telpaz, Elad Rubin, Aya Awad, Wisal Sawaed, Sarina Harshuk-Shabso, Meital Nuriel-Ohayon, Mathumathi Krishnamohan, Michal Werbner, Omry Koren, Sebastian E Winter, Ron N Apte, Elena Voronov, Shai Bel   +21 more
doaj   +1 more source

IL-1β mediates lung neutrophilia and IL-33 expression in a mouse model of viral-induced asthma exacerbation

Respiratory Research, 2018
Background Viral-induced asthma exacerbations, which exhibit both Th1-type neutrophilia and Th2-type inflammation, associate with secretion of Interleukin (IL)-1β. IL-1β induces neutrophilic inflammation. It may also increase Th2-type cytokine expression.
Irma Mahmutovic Persson, Mandy Menzel, Sangeetha Ramu, Samuel Cerps, Hamid Akbarshahi, Lena Uller   +5 more
doaj   +1 more source

Microglial NLRP3 inflammasome activation mediates IL-1β release and contributes to central sensitization in a recurrent nitroglycerin-induced migraine model

Journal of Neuroinflammation, 2019
Central sensitization is an important mechanism of chronic migraine (CM) and is related to the inflammatory response of microglia. The NOD-like receptor protein 3 (NLRP3) inflammasome may regulate the inflammatory process of microglia in several ...
Wei He, Ting Long, Qi Pan, Shanshan Zhang, Yi-Xin Zhang, Dunke Zhang, Guang-Cheng Qin, Li-Xue Chen, Ji-Ying Zhou   +8 more
semanticscholar   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Oligomerized CARD16 promotes caspase‐1 assembly and IL‐1β processing

FEBS Open Bio, 2015
Increasing evidence indicates that caspase recruitment domain (CARD)‐mediated caspase‐1 (CASP1) assembly is an essential process for its activation and subsequent interleukin (IL)‐1β release, leading to the initiation of inflammation.
Tadayoshi Karasawa, Akira Kawashima, Fumitake Usui, Hiroaki Kimura, Koumei Shirasuna, Yoshiyuki Inoue, Takanori Komada, Motoi Kobayashi, Yoshiko Mizushina, Junji Sagara, Masafumi Takahashi   +10 more
doaj   +1 more source