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Articular chondrocytes secrete IL-1, express membrane IL-1, and have IL-1 inhibitory activity
Cellular Immunology, 1992Previous work from our laboratory has shown that rabbit articular chondrocytes, like macrophages, produce reactive oxygen intermediates, express Ia antigen, and can mediate immunologic functions such as antigen presentation and induction of mixed and autologous lymphocyte reactions.
K, Tiku +3 more
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The Journal of Immunology, 1994
Abstract These studies have examined the binding of the three IL-1 ligands, IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist (IL-1 ra), to soluble forms of types I and II IL-1Rs (sIL-1RI and sIL-1RII). This interaction was measured in direct binding experiments, in which the ligands bound to immobilized sIL-1R, and in inhibition ...
W P, Arend +7 more
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Abstract These studies have examined the binding of the three IL-1 ligands, IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist (IL-1 ra), to soluble forms of types I and II IL-1Rs (sIL-1RI and sIL-1RII). This interaction was measured in direct binding experiments, in which the ligands bound to immobilized sIL-1R, and in inhibition ...
W P, Arend +7 more
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Zeitschrift für Rheumatologie, 2010
Interleukin (IL)-1 plays an important role not only in the mediation of inflammation but also in the destruction of cartilage and bone. Together with TNF-alpha it is one of the most important cytokines in the pathogenesis of rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA).
I. Kötter, G. Horneff
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Interleukin (IL)-1 plays an important role not only in the mediation of inflammation but also in the destruction of cartilage and bone. Together with TNF-alpha it is one of the most important cytokines in the pathogenesis of rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA).
I. Kötter, G. Horneff
openaire +1 more source
Induction of IL-1: independent production of IL-1 alpha and IL-1 beta.
Cytokine, 1992Lipopolysaccharide (LPS) either in its soluble form or associated with multilamellar phospholipid vesicles (liposomes) was investigated for its ability to induce human monocyte interleukin (IL)-1 alpha and IL-1 beta. When human monocytes were activated in vitro by LPS either in its soluble form or presented at the surface of lyophilized multilamellar ...
O, Bakouche, J L, Moreau, L B, Lachman
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2017
The family of IL-1 cytokines (IL-1F) encompasses eleven proteins that share similar structure and signaling mode (similar receptors, similar signaling pathways) (Dinarello 2013). IL-1F cytokines are involved in initiation as well as regulation of inflammation and are central players of innate immunity.
Boraschi, D.
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The family of IL-1 cytokines (IL-1F) encompasses eleven proteins that share similar structure and signaling mode (similar receptors, similar signaling pathways) (Dinarello 2013). IL-1F cytokines are involved in initiation as well as regulation of inflammation and are central players of innate immunity.
Boraschi, D.
openaire +2 more sources
Zeitschrift fur Rheumatologie, 2011
Interleukin (IL)-1 plays an important role not only in the mediation of inflammation but also in the destruction of cartilage and bone. Together with TNF-alpha it is one of the most important cytokines in the pathogenesis of rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA).
I, Kötter, G, Horneff
openaire +1 more source
Interleukin (IL)-1 plays an important role not only in the mediation of inflammation but also in the destruction of cartilage and bone. Together with TNF-alpha it is one of the most important cytokines in the pathogenesis of rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA).
I, Kötter, G, Horneff
openaire +1 more source