Results 1 to 10 of about 13,602,078 (332)
British Journal of Cancer, 2021 The prognosis for patients with glioblastoma (GBM), the most common and malignant type of primary brain tumour, is very poor, despite current standard treatments such as surgery, radiotherapy and chemotherapy. Moreover, the immunosuppressive tumour microenvironment hinders the development of effective immunotherapies for GBM.
Samuel S. Widodo +4 more
semanticscholar +4 more sources
Springer Reference Medizin, 2019 A study of the development of inflammatory processes of the mucous membrane, which in conditions of immune imbalance, leading to malignant transformation of the epithelium, is one of the important aspects of the pathogenesis of gastric cancer (GC). The basis of avoidance of tumor immune surveillance and the failure of the immune response are different ...
semanticscholar +4 more sources
NK Cell IL-10 Production Requires IL-15 and IL-10 Driven STAT3 Activation [PDF]
Frontiers in Immunology, 2019 Natural killer (NK) cells can produce IFNγ or IL-10 to regulate inflammation and immune responses but the factors driving NK cell IL-10 secretion are poorly-defined.
Sarah E. Clark +4 more
doaj +3 more sources
IL-10 and IL-10 Receptor Mutations in Very Early Onset Inflammatory Bowel Disease
Gastroenterology Research, 2017 Very early onset inflammatory bowel disease (VEO-IBD) is a unique disease entity with a complex genetic susceptibility in affected patients. Next-generation gene sequencing techniques have revealed various monogenetic mutations contributing to the ...
Lei Zhu +5 more
semanticscholar +4 more sources
Comparison of Serum Interleukin 10 Levels between Leprosy and Non-Leprosy Population
Mutiara Medika, 2021 Leprosy is a chronic granulomatous infectious disease that attacks the peripheral nerves, skin, and other organs. The cytokine IL-10 can deactivate macrophages, inhibit IL-12 production, which also inhibits IFN-ϒ production. IL-10 directly inhibits CD4+T
Adika Kodrati, Eddy Mart Salim, Zen Hafy
doaj +1 more source
Frontiers in Immunology, 2023 Interleukin-10 (IL-10) is a pleiotropic cytokine that has a fundamental role in modulating inflammation and in maintaining cell homeostasis. It primarily acts as an anti-inflammatory cytokine, protecting the body from an uncontrolled immune response ...
V. Carlini +6 more
semanticscholar +1 more source
Pathogens, 2022 Homologues of interleukin (IL)-10, a pleiotropic immunomodulatory cytokine, have been identified in the Parapoxvirus genus. The first identified, Orf virus (ORFV) IL-10, greatly enhanced infection of its host, exhibiting immune modulatory effects ...
Amreen Naqash +3 more
doaj +1 more source
Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages
Nature Communications, 2021 Mitochondria are important regulators of macrophage polarisation. Here, we show that arginase-2 (Arg2) is a microRNA-155 (miR-155) and interleukin-10 (IL-10) regulated protein localized at the mitochondria in inflammatory macrophages, and is critical for
J. Dowling +25 more
semanticscholar +1 more source
Tumor promoting roles of IL-10, TGF-β, IL-4, and IL-35: Its implications in cancer immunotherapy
SAGE Open Medicine, 2022 Cytokines play a critical role in regulating host immune response toward cancer and determining the overall fate of tumorigenesis. The tumor microenvironment is dominated mainly by immune-suppressive cytokines that control effector antitumor immunity and
B. Mirlekar
semanticscholar +1 more source
IL-17 and IL-10 as potential biomarkers for diagnosing periodontitis patients: A Review
Diyala Journal of Medicine, 2023 Background:Evaluation methods for periodontal disorders are continually being refined to yield more precise, reliable, and time-efficient findings.
Maha Abdulsalam Mohammed , +1 more
doaj +1 more source