Results 11 to 20 of about 11,738,321 (294)

IL-10: the master regulator of immunity to infection. [PDF]

, 2008
IL-10 is an anti-inflammatory cytokine. During infection it inhibits the activity of Th1 cells, NK cells, and macrophages, all of which are required for optimal pathogen clearance but also contribute to tissue damage.
Couper, Kevin N, Riley, Eleanor M, Blount, Daniel G, Blount, Daniel G., Couper, Kevin N., Riley, Eleanor M.   +5 more
core   +1 more source

Effect of IL-10-producing B cells in peripheral blood and tumor tissue on gastric cancer

Cell Communication and Signaling, 2023
Background Interleukin (IL)-10-producing B (B10) cells are generated in response to signals from the tumor microenvironment and promote tumor growth by interacting with B10 cells.
Yoon Ju Jung, Jin Seok Woo, Sun-Hee Hwang, SeungCheon Yang, So Jung Kim, JooYeon Jhun, Seung Yoon Lee, Kun Hee Lee, Mi-La Cho, Kyo Young Song   +9 more
doaj   +1 more source

The Effect of Homocysteine on the Secretion of Il-1β, Il-6, Il-10, Il-12 and RANTES by Peripheral Blood Mononuclear Cells—An In Vitro Study

Molecules, 2021
The contemporary theory of the inflammatory-immunological pathomechanism of atherosclerosis includes the participation of interleukin-1β (Il), Il-6, Il-10, Il-12, RANTES, and homocysteine in this process.
Magdalena Borowska, Hanna Winiarska, Marzena Dworacka, Anna Wesołowska, Grzegorz Dworacki, Przemysław Łukasz Mikołajczak   +5 more
doaj   +1 more source

Association of the IL-10 gene family locus on chromosome 1 with juvenile idiopathic arthritis (JIA) [PDF]

, 2012
The cytokine IL-10 and its family members have been implicated in autoimmune diseases and we have previously reported that genetic variants in IL-10 were associated with a rare group of diseases called juvenile idiopathic arthritis (JIA). The aim of this
Bryant, A., Ursu, S., Ursu Simona, Hinks, A, Forabosco, P, Omoyinmi, E, Ebun Omoyinmi, Hamaoui, Raja, Hinks, A., Woo, P., Ebun Omoyinmi (125984), Simona Ursu (125994), Forabosco, Paola, Wendy Thomson (68038), Lewis Cathryn M., Childhood Arthritis Response to Medication Study (CHARMS), Omoyinmi, Ebun, Lucy R. Wedderburn (125999), Thomson, W, Cathryn M Lewis, Lewis, Cathryn M; id_orcid, Forabosco Paola, Raja Hamaoui, Ursu, S, Wedderburn, L.R., Wedderburn, Lucy R., Ursu, Simona, Annette Bryant, Omoyinmi Ebun, Wedderburn, LR, ?, ?, Hamaoui Raja, Hamaoui, R., Hinks Anne, Patricia Woo, Annette Bryant (125990), Wedderburn, Lucy R, Bryant, Annette, Woo, P, Lewis, C.M., Lewis, CM, Woo, Patricia, Bryant, A, Forabosco, P., Patricia Woo (60657), Gardner-Medwin, J., Lewis, Cathryn M., Raja Hamaoui (125988), Wedderburn Lucy R., Hamaoui, R, Lucy R Wedderburn, Hinks, Anne, Cathryn M. Lewis (126002), Paola Forabosco, Anne Hinks, Omoyinmi, E., BSPAR study group, Thomson, W., Thomson Wendy, Paola Forabosco (125986), Wendy Thomson, Thomson, Wendy, Woo Patricia, Anne Hinks (23498), Bryant Annette, Simona Ursu, Childhood Arthritis Prospective Study (CAPS)   +66 more
core   +1 more source

Functional Evaluation of Computationally Designed IL-10 in IL-10 KO Mice. [PDF]

Biomolecules
Studies have shown that IL-10 has therapeutic potential for inflammatory diseases. However, it is challenging to use IL-10 as a therapeutic drug because it also possesses pro-inflammatory functions. To reduce these pro-inflammatory effects of IL-10, we have designed three IL-10 mutants using structure-based computational design technology.
Stokes J, Hyder I, Shen Z, Ramdhan P, Bayer A, Wasserfall C, Li C, Song S.   +7 more
europepmc   +3 more sources

Modulation of human immune responses by bovine interleukin-10 [PDF]

, 2011
Cytokines can be functionally active across species barriers. Bovine IL-10 has an amino acid sequence identity with human IL-10 of 76.8%. Therefore, the aim of this study was to evaluate whether bovine IL-10 has immunomodulatory activities on human ...
Schoemaker, R., de Ruiter, T., Weg-Schrijver, Elise, van de, Westphal Adrie H., Tijhaar, E., Savelkoul, H.F.J., Adrie H Westphal, Westphal, A.H., Savelkoul Huub F. J., R J Joost van Neerven, Edwin Tijhaar, Neerven, R.J.J., van, Gerco den Hartog, van de Weg-Schrijver Elise, Schoemaker Ruud, den Hartog Gerco, den Hartog, C.G., Huub F J Savelkoul, van de Weg-Schrijver, Elise, Talitha de Ruiter, Elise van de Weg-Schrijver, de Ruiter Talitha, Ruiter, T., de, Ruud Schoemaker, van Neerven, R.J.J., Hartog, C.G., den, Tijhaar Edwin, van Neerven R. J. Joost   +27 more
core   +1 more source

Regulatory B-Cells in Transplantation

Antibodies, 2013
B-cells have been long accepted as the main cellular component in humoral responses. Their effector function is based on antibody and cytokine production.
David San Segundo, Marcos López-Hoyos, Manuel Arias   +2 more
doaj   +1 more source

Cytokine responses to Schistosoma haematobium in a Zimbabwean population: contrasting profiles for IFN-γ, IL-4, IL-5 and IL-10 with age [PDF]

, 2007
Background The rate of development of parasite-specific immune responses can be studied by following their age profiles in exposed and infected hosts. This study determined the cytokine-age profiles of Zimbabweans resident in a Schistosoma haematobium ...
Mduluza Takafira, Taylor, Matthew, Georgina Winborn, Mutapi, Francisca, Maizels, Rick M, Midzi, Nicholas, Winborn, Georgina, Nicholas Midzi, Mduluza, Takafira, Midzi Nicholas, Mutapi Francisca, Rick M Maizels, Francisca Mutapi, Matthew Taylor, Maizels Rick M, Winborn Georgina, Taylor Matthew, Takafira Mduluza   +17 more
core   +1 more source

IL-10 from CD4(+)CD25(-)Foxp3(-)CD127(-) adaptive regulatory T cells modulates parasite clearance and pathology during malaria infection [PDF]

, 2008
The outcome of malaria infection is determined, in part, by the balance of pro-inflammatory and regulatory immune responses. Failure to develop an effective pro-inflammatory response can lead to unrestricted parasite replication, whilst failure to ...
Couper, Kevin N, Hafalla, Julius C, Riley, Eleanor M, Daniel G. Blount, Eleanor M Riley, Blount, Daniel G., Kevin N Couper, Richard A Flavell, Wilson, MS, de Souza, J Brian, Daniel G Blount, Mark S Wilson, Couper, KN, Blount, DG, Kamanaka, Masahito, Wilson, Mark S, Julius C. Hafalla, Belkaid, Yasmine, Masahito Kamanaka, Blount, Daniel G, Flavell, Richard A, Flavell, Richard A., J. Brian de Souza, Flavell, RA, De Souza, J. Brian, Kevin N. Couper, Kamanaka, M, Hafalla, Julius C., Julius C Hafalla, Eleanor M. Riley, Hafalla, JC, Riley, Eleanor M., Belkaid, Y, Yasmine Belkaid, De Souza, JB, Mark S. Wilson, Richard A. Flavell, Couper, Kevin N., Wilson, Mark S., Riley, EM, J Brian de Souza   +40 more
core   +1 more source

B-cell gene therapy for tolerance induction: host but not donor B cell derived IL-10 is necessary for tolerance

Frontiers in Microbiology, 2011
Genetically modified B cells are excellent tolerogenic APCs in multiple models of autoimmunity. However, the mechanisms of action are still not completely understood.
Yan eSu, Yan eSu, Ai-Hong eZhang, Ai-Hong eZhang, Nancy eNoben-Trauth, David William Scott, David William Scott   +6 more
doaj   +1 more source