Results 1 to 10 of about 1,026,832 (278)

Molecular modelling of the HCMV IL-10 protein isoforms and analysis of their interaction with the human IL-10 receptor. [PDF]

PLoS ONE, 2022
The human cytomegalovirus (HCMV) UL111A gene encodes several homologs of the cellular interleukin 10 (cIL-10). Alternative splicing in the UL111A region produces two relatively well-characterized transcripts designated cmvIL-10 (isoform A) and LAcmvIL-10
Simone Queiroz Pantaleão, Lívia de Moraes Bomediano Camillo, Tainan Cerqueira Neves, Isabela de Godoy Menezes, Lucas Matheus Stangherlin, Helena Beatriz de Carvalho Ruthner Batista, Emma Poole, Michael Nevels, Eric Alisson Philot, Ana Ligia Scott, Maria Cristina Carlan da Silva   +10 more
doaj   +8 more sources

Correction: Molecular modelling of the HCMV IL-10 protein isoforms and analysis of their interaction with the human IL-10 receptor. [PDF]

PLoS ONE, 2023
[This corrects the article DOI: 10.1371/journal.pone.0277953.].
Simone Queiroz Pantaleão, Lívia de Moraes Bomediano Camillo, Tainan Cerqueira Neves, Isabela de Godoy Menezes, Lucas Matheus Stangherlin, Helena Beatriz de Carvalho Ruthner Batista, Emma Poole, Michael Nevels, Eric Allison Philot, Ana Ligia Scott, Maria Cristina Carlan da Silva   +10 more
doaj   +6 more sources

Elevated IgA and IL-10 levels in very-early-onset inflammatory bowel disease secondary to IL-10 receptor deficiency [PDF]

Revista Paulista de Pediatria, 2021
Objective: To report two patients with very-early-onset inflammatory bowel disease (VEOIBD) secondary to interleukin-10 receptor (IL-10R) mutations, explore immunophenotyping data and plasma cytokine profile on these cases compared to healthy controls ...
Natascha Silva Sandy, Lia Furlaneto Marega, Giane Dantas Bechara, Adriana Gut Lopes Riccetto, Carmen Bonfim, Maria Marluce dos Santos Vilela, Antonio Fernando Ribeiro, Maria De Fatima Servidoni, Elizete Aparecida Lomazi   +8 more
doaj   +5 more sources

The Association of Polymorphisms in Interleukin-6 (IL-6), Interleukin-10 (IL-10), IL-6 Receptor, and IL-10 Receptor Genes with the Risk of Pediatric Inflammatory Bowel Disease [PDF]

Journal of Inflammation Research
Paulina Krawiec,1 Monika Lejman,2 Elżbieta Pac-Kożuchowska1 1Department of Pediatrics and Gastroenterology, Medical University of Lublin, Lublin, 20-059, Poland; 2Independent Laboratory of Genetic Diagnostics, Medical University of ...
Krawiec P, Lejman M, Pac-Kożuchowska E
doaj   +4 more sources

IL‐10 Receptor Neutralization–Induced Colitis in Mice: A Comprehensive Guide [PDF]

Current Protocols, 2021
AbstractInterleukin‐10 (IL‐10) and its receptor (IL‐10R) have been foremost targets to understand inflammatory bowel disease (IBD) pathogenesis. For the past several decades, IL‐10‐deficient (Il10‐/‐) mice were considered one of the best models to study immune‐mediated colitis.
Piu, Saha, Rachel M, Golonka, Ahmed A, Abokor, Beng San, Yeoh, Matam, Vijay-Kumar   +4 more
openaire   +3 more sources

IL-10 and IL-10 Receptor Mutations in Very Early Onset Inflammatory Bowel Disease [PDF]

Gastroenterology Research, 2017
Very early onset inflammatory bowel disease (VEO-IBD) is a unique disease entity with a complex genetic susceptibility in affected patients. Next-generation gene sequencing techniques have revealed various monogenetic mutations contributing to the pathogenesis of VEO-IBD, including interleukin 10 (IL-10) and IL-10 receptor (IL-10R) mutations.
Zhu, Lei, Shi, Tingting, Zhong, Chengdi, Wang, Yingde, Chang, Michael, Liu, Xiuli   +5 more
openaire   +4 more sources

Blocking IL-10 signaling with soluble IL-10 receptor restores in vitro specific lymphoproliferative response in dogs with leishmaniasis caused by Leishmania infantum. [PDF]

PLoS ONE, 2021
rIL-10 plays a major role in restricting exaggerated inflammatory and immune responses, thus preventing tissue damage. However, the restriction of inflammatory and immune responses by IL-10 can also favor the development and/or persistence of chronic ...
Catiule de Oliveira Santos, Sidnei Ferro Costa, Fabiana Santana Souza, Jessica Mariane Ferreira Mendes, Cristiane Garboggini Melo de Pinheiro, Diogo Rodrigo de Magalhães Moreira, Luciano Kalabric Silva, Valeria Marçal Felix de Lima, Geraldo Gileno de Sá Oliveira   +8 more
doaj   +2 more sources

Hepatocarcinogenesis in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): Emerging Roles of Interleukin-10 and Transcriptomic Insights into IL-10 Signaling Rewiring [PDF]

Biomedicines
Metabolic dysfunction-associated steatotic liver disease (MASLD) and its progressive inflammatory form, metabolic dysfunction-associated steatohepatitis (MASH), are increasingly recognized as key drivers of hepatocellular carcinoma (HCC).
Helena Solleiro-Villavicencio, Lucía Angélica Méndez-García, Itzel Baltazar-Pérez, Pablo Fernando Pineda-Pérez, Ana Alfaro-Cruz   +4 more
doaj   +2 more sources

IL-10 Receptor Signaling Is Essential for TR1 Cell Function In Vivo [PDF]

The Journal of Immunology, 2017
Abstract IL-10 is essential to maintain intestinal homeostasis. CD4+ T regulatory type 1 (TR1) cells produce large amounts of this cytokine and are therefore currently being examined in clinical trials as T cell therapy in patients with inflammatory bowel disease.
Leonie Brockmann, Nicola Gagliani, Babett Steglich, Anastasios D Giannou, Jan Kempski, Penelope Pelczar, Maria Geffken, Bechara Mfarrej, Francis Huber, Johannes Herkel, Yisong Y Wan, Enric Esplugues, Manuela Battaglia, Christian F Krebs, Richard A Flavell, Samuel Huber   +15 more
openaire   +3 more sources

Rational Structure-Based Rescaffolding Approach to De Novo Design of Interleukin 10 (IL-10) Receptor-1 Mimetics. [PDF]

PLoS ONE, 2016
Tackling protein interfaces with small molecules capable of modulating protein-protein interactions remains a challenge in structure-based ligand design.
Gloria Ruiz-Gómez, John C Hawkins, Jenny Philipp, Georg Künze, Robert Wodtke, Reik Löser, Karim Fahmy, M Teresa Pisabarro   +7 more
doaj   +2 more sources