Molecular modelling of the HCMV IL-10 protein isoforms and analysis of their interaction with the human IL-10 receptor. [PDF]
PLoS ONE, 2022 The human cytomegalovirus (HCMV) UL111A gene encodes several homologs of the cellular interleukin 10 (cIL-10). Alternative splicing in the UL111A region produces two relatively well-characterized transcripts designated cmvIL-10 (isoform A) and LAcmvIL-10
Simone Queiroz Pantaleão +10 more
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Correction: Molecular modelling of the HCMV IL-10 protein isoforms and analysis of their interaction with the human IL-10 receptor. [PDF]
PLoS ONE, 2023 [This corrects the article DOI: 10.1371/journal.pone.0277953.].
Simone Queiroz Pantaleão +10 more
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Elevated IgA and IL-10 levels in very-early-onset inflammatory bowel disease secondary to IL-10 receptor deficiency [PDF]
Revista Paulista de Pediatria, 2021 Objective: To report two patients with very-early-onset inflammatory bowel disease (VEOIBD) secondary to interleukin-10 receptor (IL-10R) mutations, explore immunophenotyping data and plasma cytokine profile on these cases compared to healthy controls ...
Natascha Silva Sandy +8 more
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The Association of Polymorphisms in Interleukin-6 (IL-6), Interleukin-10 (IL-10), IL-6 Receptor, and IL-10 Receptor Genes with the Risk of Pediatric Inflammatory Bowel Disease [PDF]
Journal of Inflammation ResearchPaulina Krawiec,1 Monika Lejman,2 Elżbieta Pac-Kożuchowska1 1Department of Pediatrics and Gastroenterology, Medical University of Lublin, Lublin, 20-059, Poland; 2Independent Laboratory of Genetic Diagnostics, Medical University of ...
Krawiec P, Lejman M, Pac-Kożuchowska E
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Blocking IL-10 signaling with soluble IL-10 receptor restores in vitro specific lymphoproliferative response in dogs with leishmaniasis caused by Leishmania infantum. [PDF]
PLoS ONE, 2021 rIL-10 plays a major role in restricting exaggerated inflammatory and immune responses, thus preventing tissue damage. However, the restriction of inflammatory and immune responses by IL-10 can also favor the development and/or persistence of chronic ...
Catiule de Oliveira Santos +8 more
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Cells, 2023 Cytokines secreted by individual immune cells regulate tissue regeneration and allow communication between various cell types. Cytokines bind to cognate receptors and trigger the healing process.
Krisztina Nikovics +6 more
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Rational Structure-Based Rescaffolding Approach to De Novo Design of Interleukin 10 (IL-10) Receptor-1 Mimetics. [PDF]
PLoS ONE, 2016 Tackling protein interfaces with small molecules capable of modulating protein-protein interactions remains a challenge in structure-based ligand design.
Gloria Ruiz-Gómez +7 more
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Pathogens, 2022 Homologues of interleukin (IL)-10, a pleiotropic immunomodulatory cytokine, have been identified in the Parapoxvirus genus. The first identified, Orf virus (ORFV) IL-10, greatly enhanced infection of its host, exhibiting immune modulatory effects ...
Amreen Naqash +3 more
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Virulence, 2020 Toll-like receptors (TLRs) play critical roles in the innate recognition of Mycobacterium tuberculosis (Mtb) by host immune cells. However, controversy has arisen regarding the role of TLR4 in determining the outcomes of Mtb infection.
Jaehun Park +6 more
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Anti-fibrotic actions of interleukin-10 against hypertrophic scarring by activation of PI3K/AKT and STAT3 signaling pathways in scar-forming fibroblasts. [PDF]
PLoS ONE, 2014 BACKGROUND: The hypertrophic scar (HS) is a serious fibrotic skin condition and a major clinical problem. Interleukin-10 (IL-10) has been identified as a prospective scar-improving compound based on preclinical trials. Our previous work showed that IL-10
Jihong Shi +12 more
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