Results 11 to 20 of about 77,313,502 (292)

IL-10 Receptor Neutralization-Induced Colitis in Mice: A Comprehensive Guide. [PDF]

Curr Protoc, 2021
AbstractInterleukin‐10 (IL‐10) and its receptor (IL‐10R) have been foremost targets to understand inflammatory bowel disease (IBD) pathogenesis. For the past several decades, IL‐10‐deficient (Il10‐/‐) mice were considered one of the best models to study immune‐mediated colitis.
Saha P, Golonka RM, Abokor AA, Yeoh BS, Vijay-Kumar M.   +4 more
europepmc   +4 more sources

IL-10 and IL-10 Receptor Mutations in Very Early Onset Inflammatory Bowel Disease. [PDF]

Gastroenterology Res, 2017
Very early onset inflammatory bowel disease (VEO-IBD) is a unique disease entity with a complex genetic susceptibility in affected patients. Next-generation gene sequencing techniques have revealed various monogenetic mutations contributing to the pathogenesis of VEO-IBD, including interleukin 10 (IL-10) and IL-10 receptor (IL-10R) mutations.
Zhu L, Shi T, Zhong C, Wang Y, Chang M, Liu X.   +5 more
europepmc   +4 more sources

A Comprehensive Review of IL-10 and IL-10 Receptor Deficiencies: From Basic Science to Clinical Bedside. [PDF]

Clin Rev Allergy Immunol
Xiao J, Ye Z, Huang Y.
europepmc   +2 more sources

Mucosal IL‐10 and IL‐10 receptor expression patterns in paediatric patients with ulcerative colitis

International Journal of Experimental Pathology, 2021
AbstractInterleukin‐10 (IL‐10) is a key anti‐inflammatory cytokine. We aimed to assess IL‐10 and IL‐10 receptor (IL‐10R) expression in the gut, and determine whether these patterns are altered in patients with ulcerative colitis (UC). Formalin‐fixed paraffin‐embedded rectal and transverse colon sections were collected from three groups of patients: (a)
Talya Wittmann Dayagi, Lael Werner, Marina Pinsker, Naomi Salamon, Iris Barschak, Batia Weiss, Dror S. Shouval   +6 more
openaire   +3 more sources

IL-10/IL-10 Receptor Signaling Regulates TIMP-1 Expression [PDF]

Cancer Biology & Therapy, 2002
An IL-10 responsive signal protein, termed IL-10E1, was cloned from human prostate cancer PC-3 ML cells based on its binding affinity for a novel enhancer element (i.e., HTE-1: 5’-CACGATGACTCATCACTGTTGAAAGACA-3’) of the Tissue Inhibitor of metalloproteinase-1 (TIMP-1) gene. Electrophoretic mobility shift assays (EMSAs) and enzyme linked immuno-sandwich
Min Wang, Youji Hu, Ischiro Shima, Mark E. Stearns   +3 more
openaire   +1 more source

IL-10 Receptor Signaling Is Essential for TR1 Cell Function In Vivo. [PDF]

J Immunol, 2017
Abstract IL-10 is essential to maintain intestinal homeostasis. CD4+ T regulatory type 1 (TR1) cells produce large amounts of this cytokine and are therefore currently being examined in clinical trials as T cell therapy in patients with inflammatory bowel disease.
Brockmann L, Gagliani N, Steglich B, Giannou AD, Kempski J, Pelczar P, Geffken M, Mfarrej B, Huber F, Herkel J, Wan YY, Esplugues E, Battaglia M, Krebs CF, Flavell RA, Huber S.   +15 more
europepmc   +4 more sources

Interleukin-10 (IL-10) in Experimental Visceral Leishmaniasis and IL-10 Receptor Blockade as Immunotherapy [PDF]

Infection and Immunity, 2002
ABSTRACTInterleukin-10 (IL-10) is thought to promote intracellular infection, including human visceral leishmaniasis, by disabling Th1 cell-type responses and/or deactivating parasitized tissue macrophages. To develop a rationale for IL-10 inhibition as treatment in visceral infection, Th1 cytokine-driven responses were characterized inLeishmania ...
Henry W, Murray, Christina M, Lu, Smita, Mauze, Sherry, Freeman, Andre L, Moreira, Gilla, Kaplan, Robert L, Coffman   +6 more
openaire   +2 more sources

NIL10: A New IL10-Receptor Binding Nanoparticle That Induces Cardiac Protection in Mice and Pigs Subjected to Acute Myocardial Infarction through STAT3/NF-κB Activation

Pharmaceutics, 2022
(1) Background: Early response after acute myocardial infarction (AMI) prevents extensive cardiac necrosis, in which inflammation resolution, including expression of anti-inflammatory interleukin-10 (IL-10), may play a key role.
Laura Tesoro, Ignacio Hernández, Rafael Ramírez-Carracedo, Javier Díez-Mata, Nunzio Alcharani, Beatriz Jiménez-Guirado, Karina Ovejero-Paredes, Marco Filice, Jose Luis Zamorano, Marta Saura, Carlos Zaragoza, Laura Botana   +11 more
doaj   +1 more source

B-cell gene therapy for tolerance induction: host but not donor B cell derived IL-10 is necessary for tolerance

Frontiers in Microbiology, 2011
Genetically modified B cells are excellent tolerogenic APCs in multiple models of autoimmunity. However, the mechanisms of action are still not completely understood.
Yan eSu, Yan eSu, Ai-Hong eZhang, Ai-Hong eZhang, Nancy eNoben-Trauth, David William Scott, David William Scott   +6 more
doaj   +1 more source

Blocking the Receptor for IL-10 Improves Antimycobacterial Chemotherapy and Vaccination [PDF]

The Journal of Immunology, 2001
Abstract Novel approaches are required for the prevention and therapy of mycobacterial infections since the only vaccine in use, bacillus Calmette-Guérin, is poorly effective and chemotherapy is long and often ineffective in sterilizing the infection. We used a mouse model of Mycobacterium avium infection to address the usefulness of
R A, Silva, T F, Pais, R, Appelberg
openaire   +2 more sources