Results 11 to 20 of about 1,026,832 (278)
IL-10–STAT3-Dependent Transcriptional Regulation in Microglia: Alzheimer’s Disease and Neuroinflammation [PDF]
BiomedicinesInterleukin-10 (IL-10) is a key immunoregulatory cytokine that suppresses inflammatory gene transcription in myeloid cells through signal transducer and activator of transcription 3 (STAT3). In Alzheimer’s disease and neuroinflammation, microglia express
Mi Eun Kim, Jun Sik Lee
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A Comprehensive Review of IL-10 and IL-10 Receptor Deficiencies: From Basic Science to Clinical Bedside [PDF]
Clinical Reviews in Allergy & ImmunologyJun Xiao, Ziqing Ye, Ying Huang
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Pathogens, 2022 Homologues of interleukin (IL)-10, a pleiotropic immunomodulatory cytokine, have been identified in the Parapoxvirus genus. The first identified, Orf virus (ORFV) IL-10, greatly enhanced infection of its host, exhibiting immune modulatory effects ...
Amreen Naqash +3 more
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IL-10/IL-10 Receptor Signaling Regulates TIMP-1 Expression [PDF]
Cancer Biology & Therapy, 2002 An IL-10 responsive signal protein, termed IL-10E1, was cloned from human prostate cancer PC-3 ML cells based on its binding affinity for a novel enhancer element (i.e., HTE-1: 5’-CACGATGACTCATCACTGTTGAAAGACA-3’) of the Tissue Inhibitor of metalloproteinase-1 (TIMP-1) gene. Electrophoretic mobility shift assays (EMSAs) and enzyme linked immuno-sandwich
Min Wang +3 more
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Cells, 2023 Cytokines secreted by individual immune cells regulate tissue regeneration and allow communication between various cell types. Cytokines bind to cognate receptors and trigger the healing process.
Krisztina Nikovics +6 more
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Mucosal IL‐10 and IL‐10 receptor expression patterns in paediatric patients with ulcerative colitis
International Journal of Experimental Pathology, 2021 AbstractInterleukin‐10 (IL‐10) is a key anti‐inflammatory cytokine. We aimed to assess IL‐10 and IL‐10 receptor (IL‐10R) expression in the gut, and determine whether these patterns are altered in patients with ulcerative colitis (UC). Formalin‐fixed paraffin‐embedded rectal and transverse colon sections were collected from three groups of patients: (a)
Talya Wittmann Dayagi +6 more
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Virulence, 2020 Toll-like receptors (TLRs) play critical roles in the innate recognition of Mycobacterium tuberculosis (Mtb) by host immune cells. However, controversy has arisen regarding the role of TLR4 in determining the outcomes of Mtb infection.
Jaehun Park +6 more
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Anti-fibrotic actions of interleukin-10 against hypertrophic scarring by activation of PI3K/AKT and STAT3 signaling pathways in scar-forming fibroblasts. [PDF]
PLoS ONE, 2014 BACKGROUND: The hypertrophic scar (HS) is a serious fibrotic skin condition and a major clinical problem. Interleukin-10 (IL-10) has been identified as a prospective scar-improving compound based on preclinical trials. Our previous work showed that IL-10
Jihong Shi +12 more
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Interleukin-10 (IL-10) in Experimental Visceral Leishmaniasis and IL-10 Receptor Blockade as Immunotherapy [PDF]
Infection and Immunity, 2002 ABSTRACTInterleukin-10 (IL-10) is thought to promote intracellular infection, including human visceral leishmaniasis, by disabling Th1 cell-type responses and/or deactivating parasitized tissue macrophages. To develop a rationale for IL-10 inhibition as treatment in visceral infection, Th1 cytokine-driven responses were characterized inLeishmania ...
Henry W, Murray +6 more
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Pharmaceutics, 2022 (1) Background: Early response after acute myocardial infarction (AMI) prevents extensive cardiac necrosis, in which inflammation resolution, including expression of anti-inflammatory interleukin-10 (IL-10), may play a key role.
Laura Tesoro +11 more
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