Results 21 to 30 of about 77,313,502 (292)

Pro-inflammatory signaling by IL-10 and IL-22: bad habit stirred up by interferons? [PDF]

, 2013
Interleukin (IL)-10 and IL-22 are key members of the IL-10 cytokine family that share characteristic properties such as defined structural features, usage of IL-10R2 as one receptor chain, and activation of signal transducer and activator of ...
Heiko Mühl, Heiko eMühl, Mühl, Heiko
core   +1 more source

IL-10 and IL-10 receptor overexpression in oral giant cell lesions

Medicina Oral Patología Oral y Cirugia Bucal, 2011
Central giant cell lesions (CGCL) and peripheral giant cell lesions (PGCL) occur in the jaws and contain osteoclast-like giant cells and mononuclear cells positive for the macrophage marker CD68. The participation of immune-inflammatory mechanisms has been proposed in the lesions development.
Syrio, Nárriman Fátima Lima, Faria, Daniela Rodrigues, Gomez, Ricardo Santiago, Gollob, Kenneth John, Dutra, Walderez Ornelas, Souza, Paulo Eduardo Alencar   +5 more
openaire   +3 more sources

Pseudaminic acid on Campylobacter jejuni flagella modulates dendritic cell IL-10 expression via Siglec-10 receptor: a novel flagellin-host interaction. [PDF]

, 2014
INTRODUCTION: Campylobacter jejuni is a leading cause of bacterial gastroenteritis worldwide. At present the identity of host-pathogen interactions that promote successful bacterial colonisation remain ill defined.
Crocker, Paul R., Stephenson, Holly N, Escors, David, Copland, Alastair, Crocker, Paul R, Wren, Brendan W, Dorrell, Nick, Jones, Hannah, Stephenson, Holly N., Wren, Brendan W., Mills, Dominic C, Milioris, Enea, Mills, Dominic C., Bajaj-Elliott, Mona   +13 more
core   +1 more source

NanoAPC deliver antigen, IL-2 and co-stimulatory molecules to antigen specific T cells and activate viral specific T cells in chronic infections [PDF]

, 2011
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The study of the immune system has provided insight in the mechanism of protection induced by vaccination; primarily that most clinically protective ...
Liu, Mengya
core   +6 more sources

Suppression of TGF-β and IL-10 receptors on self-differentiated dendritic cells by short-hairpin RNAs enhanced activation of effector T-cells against cholangiocarcinoma cells

Human Vaccines & Immunotherapeutics, 2020
Cholangiocarcinoma (CCA) is an aggressive tumor that is associated with high rates of recurrence and mortality. This is due, in part, to the fact that CCA cells and their microenvironment secrete immunosuppressive cytokines, transforming growth factor-β (
Chutamas Thepmalee, Aussara Panya, Jatuporn Sujjitjoon, Nunghathai Sawasdee, Naravat Poungvarin, Mutita Junking, Pa-Thai Yenchitsomanus   +6 more
doaj   +1 more source

Implication of the Transmembrane Domain in the Interleukin 10 Receptor Platform Oligomerisation

Cells, 2023
Interleukin 10 (IL-10) exerts anti-inflammatory and immune regulatory roles through its fixation to the IL-10 receptor (IL-10R). The two subunits (IL-10Rα and IL-10Rβ) organise themselves to form a hetero-tetramer to induce the activation of the ...
Thomas Kuntzel, Caroline Spenlé, Lucas D. Pham-Van, Dafni Birmpili, Aurélien Riou, Aurore Loeuillet, Imane Charmarke-Askar, Dominique Bagnard   +7 more
doaj   +1 more source

Targeting of interleukin-10 receptor by a potential human interleukin-10 peptide efficiently blocks interleukin-10 pathway-dependent cell proliferation

Tzu Chi Medical Journal, 2020
Objective: Human interleukin-10 (IL-10) is a dimeric and pleiotropic cytokine that plays a crucial role in cellular immunoregulatory responses. As IL-10 binds to its receptors, IL-10Ra and IL-10Rb, it will suppress or induce the downstream cellular ...
Chun-Chun Chang, Cheng-Der Liu, Sheng-Feng Pan, Wei-Han Huang, Chih-Wen Peng, Hao-Jen Hsu   +5 more
doaj   +1 more source

Inhibition of IL-10 Receptor Function in Alveolar Macrophages by Toll-Like Receptor Agonists [PDF]

The Journal of Immunology, 2004
Abstract Despite an immunosuppressive lung environment, alveolar macrophages (AM) retain the capacity to respond to microorganisms. This report demonstrates that IL-10, constitutively produced by normal alveolar epithelium, stimulates signal transduction through the IL-10R on AM and that IL-10R function can be inhibited by stimulation
Stefan, Fernandez, Purnima, Jose, Margarita G, Avdiushko, Alan M, Kaplan, Donald A, Cohen   +4 more
openaire   +2 more sources

Hematopoietic cell transplantation using treosulfan-based conditioning for IL-10 receptor deficiencyTreosulfan-based approach for IL-10 receptor deficiency [PDF]

Journal of Human Immunity
Lakkaraja and Schmitt et al. observe that IL-10 receptor deficiency is a life-threatening inborn error of immunity associated with early-onset inflammatory bowel disease and found that employing hematopoietic cell transplantation (HCT) using treosulfan ...
Madhavi Lakkaraja, Erica G. Schmitt, Amika K. Sood, Karin Chen, Arunkumar J. Modi, James W. Verbsky, Troy Torgerson, Ghassan Wahbeh, Aleksandra Petrovic, K. Scott Baker, Megan A. Cooper, Lauri M. Burroughs   +11 more
doaj   +1 more source

IL-10 Inhibits miR-155 Induction by Toll-like Receptors [PDF]

Journal of Biological Chemistry, 2010
IL-10 is a potent anti-inflammatory cytokine that is crucial for down-regulating pro-inflammatory genes, which are induced by Toll-like receptor (TLR) signaling. In this study, we have examined whether modulation of microRNAs plays a role in the inhibitory effect of IL-10 on TLR4 signaling. Analyzing microRNAs known to be induced by TLR4, we found that
Claire E, McCoy, Frederick J, Sheedy, Joseph E, Qualls, Sarah L, Doyle, Susan R, Quinn, Peter J, Murray, Luke A J, O'Neill   +6 more
openaire   +4 more sources