Results 41 to 50 of about 1,026,832 (278)

Aryl Hydrocarbon Receptor Promotes IL-10 Expression in Inflammatory Macrophages Through Src-STAT3 Signaling Pathway

Frontiers in Immunology, 2018
The aryl hydrocarbon receptor (AhR) is an important immune regulator with a role in inflammatory response. However, the role of AhR in IL-10 production by inflammatory macrophages is currently unknown.
Junyu Zhu, Li Luo, Lixing Tian, Shangqi Yin, Xiaoyuan Ma, Xiaoyuan Ma, Shaowen Cheng, Wanqi Tang, Jing Yu, Wei Ma, Xiaoying Zhou, Xia Fan, Xue Yang, Jun Yan, Xiang Xu, Chuanzhu Lv, Huaping Liang   +16 more
doaj   +1 more source

In vitro generation of interleukin-10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper 1 (Th1)- and Th2-inducing cytokines [PDF]

, 2002
We show that a combination of the immunosuppressive drugs, vitamin D3 and Dexamethasone, induced human and mouse naive CD4(+) T cells to differentiate in vitro into regulatory T cells.
Hawrylowicz, C.M., Robert L. Coffman, André Boonstra, Richards, David F, Richards, D.F., Catherine M. Hawrylowicz, Savelkoul, H.F.J., Savelkoul, HFJ (Huub), Crain, Chad, Anne O'Garra, O' Garra, A, de Waal-Malefyt, R., Coffman, R.L., O'Garra, Anne, Cua, D.J., Chad Crain, Cua, DJ, Huub F. Savelkoul, Coffman, RL, Waal-Malefyt, R., de, Cua, Daniel J, Savelkoul, Huub F, Barrat, Franck J, de Waal-Malefyt, René, de Waal-Malefyt, R, Hawrylowicz, Catherine M; id_orcid, Crain, C., Barrat, FJ, Barrat, F.J., Crain, C, Coffman, Robert L, Boonstra, P.A., Daniel J. Cua, Hawrylowicz, CM, Franck J. Barrat, David F. Richards, O'Garra, A., René de Waal-Malefyt, Richards, DF, Boonstra, Andre   +39 more
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Expression of the Inhibitory CD200 Receptor Is Associated with Alternative Macrophage Activation [PDF]

, 2010
Classical macrophage activation is inhibited by the CD200 receptor (CD200R). Here, we show that CD200R expression was specifically induced on human in vitro polarized macrophages of the alternatively activated M2a subtype, generated by incubation with IL-
Brouwer, Michael S. M., Huitinga, I., Voehringer, David, Raes, G., van Eijk, Marco, Hoek, Robert M., Hamann, J., Huitinga, Inge, Koning, N., Brouwer, M.S., Raes, Geert, Pouwels, W., Voehringer, D., Koning, Nathalie, Van Eijk, M., Hoek, R.M., Pouwels, Walter, Hamann, Jörg   +17 more
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Toll-like Receptor 2 Activation Promotes Tumor Dendritic Cell Dysfunction by Regulating IL-6 and IL-10 Receptor Signaling

Cell Reports, 2015
Although dendritic cell (DC) dysfunction in cancer is a well-recognized consequence of cancer-associated inflammation that contributes to immune evasion, the mechanisms that drive this process remain elusive.
Michael Tang, Jun Diao, Hongtao Gu, Ismat Khatri, Jun Zhao, Mark S. Cattral   +5 more
doaj   +1 more source

IL-13R alpha 2 reverses the effects of IL-13 and IL-4 on bronchial reactivity and acetylcholine-induced Ca2+ signaling [PDF]

, 2007
Background: The interleukins IL-4 and IL-13 play a key role in the pathophysiology of asthma. The interleukin receptor IL-13R alpha 2 is believed to act as a decoy receptor, but until now, the functional significance of IL-13R alpha 2 remains vague ...
Kellner, Julia, Welsch, Ulrich, Joerres, Rudolf A., Bergner, Albrecht, Gamarra, Fernando, Huber, Rudolf M., Jörres, Rudolf A.   +6 more
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Lactobacillus rhamnosus (LGG) regulates IL-10 signaling in the developing murine colon through upregulation of the IL-10R2 receptor subunit.

PLoS ONE, 2012
The intestinal microflora is critical for normal development, with aberrant colonization increasing the risk for necrotizing enterocolitis (NEC). In contrast, probiotic bacteria have been shown to decrease its incidence.
Julie Mirpuri, Ilya Sotnikov, Loren Myers, Timothy L Denning, Felix Yarovinsky, Charles A Parkos, Patricia W Denning, Nancy A Louis   +7 more
doaj   +1 more source

Circulating interleukin-10 and risk of cardiovascular events: a prospective study in the elderly at risk [PDF]

, 2011
<p><b>Objective:</b> The goal of this study was to examine the association of the antiinflammatory interleukin-10 (IL-10) with risk of cardiovascular disease (CVD).</p> <p><b>Methods and Results:</b> In the ...
Jukema, J.W., Trompet, S., Sattar, N., David J. Stott, Jukema, J. Wouter, Heather M. Murray, Ian Ford, Ford, I., Welsh, Paul, Anton J.M. de Craen, McInnes, Iain B., Trompet, Stella, Paul Welsh, J. Wouter Jukema, Westendorp, Rudi G.J., McInnes, I.B., Welsh, P., Westendorp, R.G.J., Packard, C.J., Murray, H.M., Craen, A.J.M. de, de Craen, Anton J.M., Rudi G.J. Westendorp, Sattar, Naveed, Stella Trompet, Stott, David J., Naveed Sattar, Ford, Ian, Chris J. Packard, Murray, Heather M., PROSPER Study Grp, Packard, Chris J., Iain B. McInnes, Stott, D.J.   +33 more
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A peptide derived from interleukin-10 exhibits potential anticancer activity and can facilitate cell targeting of gold nanoparticles loaded with anticancer therapeutics

Communications Chemistry, 2023
Human interleukin-10 (IL-10) is an immunosuppressive and anti-inflammatory cytokine, and its expression is upregulated in tumor tissues and serum samples of patients with various cancers.
Chun-Chun Chang, Chin-Hao Yang, Chin-Hsien Chuang, Shinn-Jong Jiang, Yin-Min Hwang, Je-Wen Liou, Hao-Jen Hsu   +6 more
doaj   +1 more source

Early production of IL-22 but not IL-17 by peripheral blood mononuclear cells exposed to live Borrelia burgdorferi: the role of monocytes and interleukin-1 [PDF]

, 2010
If insufficiently treated, Lyme borreliosis can evolve into an inflammatory disorder affecting skin, joints, and the CNS. Early innate immunity may determine host responses targeting infection. Thus, we sought to characterize the immediate cytokine storm
Nicole Darsow, Kind, Peter, Rudloff, Ina, Klaus-Peter Hunfeld, Katharina Horn, Itamar Goren, Urs Christen, Kraiczy Peter, Horn Katharina, Pfeilschifter, Josef (Prof. Dr.), Mühl Heiko, Koehl Ulrike, Peter Kind, Goren Itamar, Pfeilschifter, Josef, Peter Kraiczy, Rudloff Ina, Goren, Itamar, Mühl, Heiko, Darsow, Nicole, Christen Urs, Kraiczy, Peter, Christen, Urs, Holdener, Martin, Horn, Katharina, Hunfeld, Klaus-Peter, Ulrike Koehl, Hunfeld Klaus-Peter, Heiko Mühl, Ina Rudloff, Malte Bachmann, Martin Holdener, Holdener Martin, Koehl, Ulricke, Bachmann Malte, Darsow Nicole, Kind Peter, Köhl, Ulrike, Josef Pfeilschifter, Bachmann, Malte, Pfeilschifter Josef   +40 more
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Signaling via the Interleukin-10 Receptor Attenuates Cardiac Hypertrophy in Mice During Pressure Overload, but not Isoproterenol Infusion

Frontiers in Pharmacology, 2020
Inflammation plays a key role during cardiac hypertrophy and the development of heart failure. Interleukin-10 (IL-10) is a major anti-inflammatory cytokine that is expressed in the heart and may play a crucial role in cardiac remodeling.
Nicholas Stafford, Nicholas Stafford, Farryah Assrafally, Farryah Assrafally, Sukhpal Prehar, Sukhpal Prehar, Min Zi, Min Zi, Ana M. De Morais, Ana M. De Morais, Arfa Maqsood, Arfa Maqsood, Elizabeth J. Cartwright, Elizabeth J. Cartwright, Werner Mueller, Delvac Oceandy, Delvac Oceandy   +16 more
doaj   +1 more source