Results 31 to 40 of about 1,026,832 (278)

IL-10 Inhibits miR-155 Induction by Toll-like Receptors [PDF]

Journal of Biological Chemistry, 2010
IL-10 is a potent anti-inflammatory cytokine that is crucial for down-regulating pro-inflammatory genes, which are induced by Toll-like receptor (TLR) signaling. In this study, we have examined whether modulation of microRNAs plays a role in the inhibitory effect of IL-10 on TLR4 signaling. Analyzing microRNAs known to be induced by TLR4, we found that
Claire E, McCoy, Frederick J, Sheedy, Joseph E, Qualls, Sarah L, Doyle, Susan R, Quinn, Peter J, Murray, Luke A J, O'Neill   +6 more
openaire   +4 more sources

Cytoplasmic tail of IL-13Ralpha2 regulates IL-4 signal transduction [PDF]

, 2009
IL (interleukin)-4 and IL-13 are key cytokines in the pathogenesis of allergic inflammatory disease. IL-4 and IL-13 share many functional properties as a result of their utilization of a common receptor complex comprising IL-13Ralpha1 (IL-13 receptor ...
Donna E. Davies, Holgate, Stephen T, Isabelle Kirby, Ida Karin Nordgren, Tavassoli, Ali, Davies, Donna E, Holloway, John W, Andrews, Allison-Lynn, Stephen T. Holgate, Nordgren, Ida Karin, John W. Holloway, Kirby, Isabelle, Allison-Lynn Andrews, Ali Tavassoli   +13 more
core   +1 more source

A common variant of the interleukin 6 receptor (IL-6r) gene increases IL-6r and IL-6 levels, without other inflammatory effects. [PDF]

, 2007
Interleukin-6 (IL-6) is a key inflammatory cytokine, signalling to most tissues by binding to a soluble IL-6 receptor (sIL-6r), making a complex with gp130.
A Murray, Henley, W, Bandinelli, S, S Rafiq, Rafiq, S, Weedon, MN, Guralnik, JM, Hurst, A, A-M Corsi, Ferrucci, L, K Stevens, S Bandinelli, M N Weedon, Corsi, A-M, L Ferrucci, Murray, A, D Melzer, W Henley, T M Frayling, J M Guralnik, A Hurst, Stevens, K, Melzer, D, Frayling, TM   +23 more
core   +1 more source

Association of the IL-10 gene family locus on chromosome 1 with juvenile idiopathic arthritis (JIA) [PDF]

, 2012
The cytokine IL-10 and its family members have been implicated in autoimmune diseases and we have previously reported that genetic variants in IL-10 were associated with a rare group of diseases called juvenile idiopathic arthritis (JIA). The aim of this
Bryant, A., Ursu, S., Ursu Simona, Hinks, A, Forabosco, P, Omoyinmi, E, Ebun Omoyinmi, Hamaoui, Raja, Hinks, A., Woo, P., Ebun Omoyinmi (125984), Simona Ursu (125994), Forabosco, Paola, Wendy Thomson (68038), Lewis Cathryn M., Childhood Arthritis Response to Medication Study (CHARMS), Omoyinmi, Ebun, Lucy R. Wedderburn (125999), Thomson, W, Cathryn M Lewis, Lewis, Cathryn M; id_orcid, Forabosco Paola, Raja Hamaoui, Ursu, S, Wedderburn, L.R., Wedderburn, Lucy R., Ursu, Simona, Annette Bryant, Omoyinmi Ebun, Wedderburn, LR, ?, ?, Hamaoui Raja, Hamaoui, R., Hinks Anne, Patricia Woo, Annette Bryant (125990), Wedderburn, Lucy R, Bryant, Annette, Woo, P, Lewis, C.M., Lewis, CM, Woo, Patricia, Bryant, A, Forabosco, P., Patricia Woo (60657), Gardner-Medwin, J., Lewis, Cathryn M., Raja Hamaoui (125988), Wedderburn Lucy R., Hamaoui, R, Lucy R Wedderburn, Hinks, Anne, Cathryn M. Lewis (126002), Paola Forabosco, Anne Hinks, Omoyinmi, E., BSPAR study group, Thomson, W., Thomson Wendy, Paola Forabosco (125986), Wendy Thomson, Thomson, Wendy, Woo Patricia, Anne Hinks (23498), Bryant Annette, Simona Ursu, Childhood Arthritis Prospective Study (CAPS)   +66 more
core   +1 more source

IL-10: the master regulator of immunity to infection. [PDF]

, 2008
IL-10 is an anti-inflammatory cytokine. During infection it inhibits the activity of Th1 cells, NK cells, and macrophages, all of which are required for optimal pathogen clearance but also contribute to tissue damage.
Couper, Kevin N, Riley, Eleanor M, Blount, Daniel G, Blount, Daniel G., Couper, Kevin N., Riley, Eleanor M.   +5 more
core   +1 more source

Interleukin-10: A double-edged sword in breast cancer

Tzu Chi Medical Journal, 2021
Breast cancer (BC) is a frequently diagnosed cancer among women worldwide. Currently, BC can be divided into different subgroups according to the presence of the following hormone receptors: estrogen receptor, progesterone receptor, and human epidermal ...
Chun-Ming Chang, Ho Yin Pekkle Lam, Hao-Jen Hsu, Shinn-Jong Jiang   +3 more
doaj   +1 more source

Association of IL-10 receptor 2 (IL10RB) SNP with systemic sclerosis [PDF]

Biochemical and Biophysical Research Communications, 2008
Interleukin-10 (IL-10) signaling has been suggested to play a role in systemic sclerosis (SSc). IL10RB codes for IL-10 receptor 2 (IL-10R2), a component shared in receptor complexes for IL-10, IL-22, IL-26 and interferon (IFN)-lambda. In this study, we examined association of IL10RB polymorphism with susceptibility to SSc.
Koki, Hikami, Yukikazu, Ehara, Minoru, Hasegawa, Manabu, Fujimoto, Masaki, Matsushita, Takanori, Oka, Kazuhiko, Takehara, Shinichi, Sato, Katsushi, Tokunaga, Naoyuki, Tsuchiya   +9 more
openaire   +2 more sources

Clinical outcome in IL-10– and IL-10 receptor–deficient patients with or without hematopoietic stem cell transplantation

Journal of Allergy and Clinical Immunology, 2013
Inherited deficiencies of IL-10 or IL-10 receptor (IL-10R) lead to immune dysregulation with life-threatening early-onset enterocolitis.We sought to gather clinical data of IL-10/IL-10R-deficient patients and devise guidelines for diagnosis and management, including hematopoietic stem cell transplantation (HSCT).We enrolled 40 patients with early-onset
Engelhardt, Karin R., Shah, Neil, Faizura-Yeop, Intan, Kocacik Uygun, Dilara F., Frede, Natalie, Muise, Aleixo M., Shteyer, Eyal, Filiz, Serkan, Chee, Ronnie, Elawad, Mamoun, Hartmann, Britta, Arkwright, Peter D., Dvorak, Christopher C., Klein, Christoph, Puck, Jennifer M., Grimbacher, Bodo, Glocker, Erik-Oliver   +16 more
openaire   +4 more sources

The Aryl Hydrocarbon Receptor Promotes IL-10 Production by NK Cells [PDF]

The Journal of Immunology, 2014
Abstract The cytokine IL-10 has an important role in limiting inflammation in many settings, including toxoplasmosis. In the present studies, an IL-10 reporter mouse was used to identify the sources of this cytokine following challenge with Toxoplasma gondii. During infection, multiple cell types expressed the IL-10 reporter but NK cells
Sagie, Wagage, Beena, John, Bryan L, Krock, Aisling O'Hara, Hall, Louise M, Randall, Christopher L, Karp, M Celeste, Simon, Christopher A, Hunter   +7 more
openaire   +2 more sources

Expression of interleukin-18 receptor in fibroblast-like synoviocytes [PDF]

, 2001
An excess of the proinflammatory substance IL-18 is present in joints of patients with rheumatoid arthritis (RA), and expression of IL-18 receptor (IL-18R) regulates IL-18 bioactivity in various cell types.
Hoelzer, Dieter (Prof. Dr.), Rehart, Stefan, Kalina, Uwe, Kessler, Uta, Kukoc-Zivojnov, Natasa, Kaltwasser, Joachim Peter (Prof. Dr.), Ottmann, Oliver G., Möller, Burkhard   +7 more
core   +1 more source