Results 201 to 210 of about 2,038,009 (287)

Dynamical modeling of TNF-α, IL-6, and IL-10 interactions in stroke-induced inflammation. [PDF]

PLoS One
Arishi FAM, Rambely AS, Abdul Razak F.
europepmc   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

IL-10 and IL-6/IL-10 as predictive biomarkers for treatment response in non-infectious uveitis. [PDF]

Front Immunol
Valenzuela RA, Vega-Tapia F, Elizalde N, Flores I, Rojas FM, Goecke A, Cuitino L, Urzua CA.   +7 more
europepmc   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Cytomegalovirus IL-10 in Plasma as a Marker of Active Infection in Allogeneic Hematopoietic Transplant Recipients: An Exploratory Study. [PDF]

J Med Virol
Sánchez-Simarro Á, Albert E, Giménez E, Colomer E, Pérez A, Piñana JL, Solano C, Navarro D.   +7 more
europepmc   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Correlation Between Intrafollicular IL-10, Progesterone, and Bovine Oocyte Developmental Competence. [PDF]

Int J Mol Sci
Pytel AT, Tobolski D, Skup P, Strączyńska P, Domrazek K, Gajewski Z, Gorodkiewicz E, Papis K.   +7 more
europepmc   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Role of IL-10 signaling in the circadian control of host response to influenza infection. [PDF]

Mucosal Immunol
Forrest KM, Towers ME, Paul O, Cho H, Padmini MV, Naik A, Lim HK, Issah Y, Tang SY, Deshmukh HS, Abt MC, Hudock KM, Eisenlohr LC, Grant GR, Brooks TG, Sengupta S.   +15 more
europepmc   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source