Polycistronic Delivery of IL-10 and NT-3 Promotes Oligodendrocyte Myelination and Functional Recovery in a Mouse Spinal Cord Injury Model. [PDF]
, 2020 One million estimated cases of spinal cord injury (SCI) have been reported in the United States and repairing an injury has constituted a difficult clinical challenge.
Anderson, Aileen J +8 more
core +1 more source
Journal of Experimental Medicine, 1991 In the present study we demonstrate that human monocytes activated by lipopolysaccharides (LPS) were able to produce high levels of interleukin 10 (IL-10), previously designated cytokine synthesis inhibitory factor (CSIF), in a dose dependent fashion. IL-
R. de Waal Malefyt +4 more
semanticscholar +1 more source
Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1 [PDF]
, 2014 During the course of many chronic viral infections, the antiviral T cell response becomes attenuated through a process that is regulated in part by the host. While elevated expression of the immunosuppressive cytokine IL-10 is involved in the suppression
Brüstle, Anne +12 more
core +1 more source
Effect of IL-10-producing B cells in peripheral blood and tumor tissue on gastric cancer
Cell Communication and Signaling, 2023 Background Interleukin (IL)-10-producing B (B10) cells are generated in response to signals from the tumor microenvironment and promote tumor growth by interacting with B10 cells.
Yoon Ju Jung +9 more
doaj +1 more source
Saliva as Alternative Specimen for Measuring Inflammatory Markers Interleukins (IL10, IL-4, and IL-1β) in Association with Disease Severity among COVID-19 Patients [PDF]
International Journal of Biomedicine, 2023 Background: Saliva is a specimen that is easily collected by non-invasive means and does not require well-trained staff; it could be helpful in measuring inflammatory markers to determine COVID-19 severity. The aim of this study was to investigate saliva
Samia M. Ahmed +6 more
doaj +1 more source
Molecules, 2021 The contemporary theory of the inflammatory-immunological pathomechanism of atherosclerosis includes the participation of interleukin-1β (Il), Il-6, Il-10, Il-12, RANTES, and homocysteine in this process.
Magdalena Borowska +5 more
doaj +1 more source
Metabolomic profiles are gender, disease and time specific in the interleukin-10 gene-deficient mouse model of inflammatory bowel disease. [PDF]
, 2013 Metabolomic profiling can be used to study disease-induced changes in inflammatory bowel diseases (IBD). The aim of this study was to investigate the difference in the metabolomic profile of males and females as they developed IBD.
Churchill, Thomas A +6 more
core +7 more sources
IL-10 inhibits cytokine production by activated macrophages.
Journal of Immunology, 1991 IL-10 inhibits the ability of macrophage but not B cell APC to stimulate cytokine synthesis by Th1 T cell clones. In this study we have examined the direct effects of IL-10 on both macrophage cell lines and normal peritoneal macrophages.
D. Fiorentino +4 more
semanticscholar +1 more source
Extracellular vesicle–encapsulated IL-10 as novel nanotherapeutics against ischemic AKI
Science Advances, 2020 Using extracellular vesicles for targeted delivery of IL-10 is an efficient therapeutic strategy against ischemic AKI. Recently, extracellular vesicles (EVs) have been attracting strong research interest for use as natural drug delivery systems.
T. Tang +11 more
semanticscholar +1 more source
Regulatory B-Cells in Transplantation
Antibodies, 2013 B-cells have been long accepted as the main cellular component in humoral responses. Their effector function is based on antibody and cytokine production.
David San Segundo +2 more
doaj +1 more source