Results 21 to 30 of about 15,170,590 (380)

Longitudinal COVID-19 profiling associates IL-1Ra and IL-10 with disease severity and RANTES with mild disease.

JCI Insight, 2020
Background Identifying immune correlates of COVID-19 disease severity is an urgent need for clinical management, vaccine evaluation and drug development.
Yan Zhao, Ling Qin, Ping Zhang, Kang Li, Lian-chun Liang, Jianping Sun, Bin Xu, Yanchao Dai, Xuemei Li, Chi Zhang, Yanchun Peng, Yingmei Feng, Ang Li, Zhongjie Hu, Haiping Xiang, G. Ogg, L. Ho, A. McMichael, R. Jin, J. Knight, T. Dong, Yonghong Zhang   +21 more
semanticscholar   +1 more source

Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes

Journal of Experimental Medicine, 1991
In the present study we demonstrate that human monocytes activated by lipopolysaccharides (LPS) were able to produce high levels of interleukin 10 (IL-10), previously designated cytokine synthesis inhibitory factor (CSIF), in a dose dependent fashion. IL-
John S. Abrams, B. Bennett, C. G. Figdor, J. D. Vries   +3 more
semanticscholar   +1 more source

Polycistronic Delivery of IL-10 and NT-3 Promotes Oligodendrocyte Myelination and Functional Recovery in a Mouse Spinal Cord Injury Model. [PDF]

, 2020
One million estimated cases of spinal cord injury (SCI) have been reported in the United States and repairing an injury has constituted a difficult clinical challenge.
Anderson, Aileen J, Ciciriello, Andrew J, Cummings, Brian J, Dumont, Courtney M, Guo, Amina, Park, Jonghyuck, Shea, Lonnie D, Smith, Dominique R, Tatineni, Ravindra   +8 more
core   +1 more source

Effect of IL-10-producing B cells in peripheral blood and tumor tissue on gastric cancer

Cell Communication and Signaling, 2023
Background Interleukin (IL)-10-producing B (B10) cells are generated in response to signals from the tumor microenvironment and promote tumor growth by interacting with B10 cells.
Yoon Ju Jung, Jin Seok Woo, Sun-Hee Hwang, SeungCheon Yang, So Jung Kim, JooYeon Jhun, Seung Yoon Lee, Kun Hee Lee, Mi-La Cho, Kyo Young Song   +9 more
doaj   +1 more source

Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1 [PDF]

, 2014
During the course of many chronic viral infections, the antiviral T cell response becomes attenuated through a process that is regulated in part by the host. While elevated expression of the immunosuppressive cytokine IL-10 is involved in the suppression
Brüstle, Anne, Chen, Jonathan H, Cui, Weiguo, Kaech, Susan M, Laidlaw, Brian J, Lang, Philipp A, Marshall, Heather D, Ohashi, Pamela, Parish, Ian A, Perry, Curtis, Staron, Matthew M, Tsui, Yao-Chen, Weaver, Casey T   +12 more
core   +1 more source

The Effect of Homocysteine on the Secretion of Il-1β, Il-6, Il-10, Il-12 and RANTES by Peripheral Blood Mononuclear Cells—An In Vitro Study

Molecules, 2021
The contemporary theory of the inflammatory-immunological pathomechanism of atherosclerosis includes the participation of interleukin-1β (Il), Il-6, Il-10, Il-12, RANTES, and homocysteine in this process.
Magdalena Borowska, Hanna Winiarska, Marzena Dworacka, Anna Wesołowska, Grzegorz Dworacki, Przemysław Łukasz Mikołajczak   +5 more
doaj   +1 more source

IL-10 inhibits cytokine production by activated macrophages.

Journal of Immunology, 1991
IL-10 inhibits the ability of macrophage but not B cell APC to stimulate cytokine synthesis by Th1 T cell clones. In this study we have examined the direct effects of IL-10 on both macrophage cell lines and normal peritoneal macrophages.
D. Fiorentino, A. Zlotnik, T. Mosmann, M. Howard, A. O’Garra   +4 more
semanticscholar   +1 more source

Circulating interleukin-10 and risk of cardiovascular events: a prospective study in the elderly at risk [PDF]

, 2011
<p><b>Objective:</b> The goal of this study was to examine the association of the antiinflammatory interleukin-10 (IL-10) with risk of cardiovascular disease (CVD).</p> <p><b>Methods and Results:</b> In the ...
Craen, A.J.M. de, Ford, I., Jukema, J.W., McInnes, I.B., Murray, H.M., Packard, C.J., PROSPER Study Grp, Sattar, N., Stott, D.J., Trompet, S., Welsh, P., Westendorp, R.G.J.   +11 more
core   +1 more source

Regulatory B-Cells in Transplantation

Antibodies, 2013
B-cells have been long accepted as the main cellular component in humoral responses. Their effector function is based on antibody and cytokine production.
David San Segundo, Marcos López-Hoyos, Manuel Arias   +2 more
doaj   +1 more source

Extracellular vesicle–encapsulated IL-10 as novel nanotherapeutics against ischemic AKI

Science Advances, 2020
Using extracellular vesicles for targeted delivery of IL-10 is an efficient therapeutic strategy against ischemic AKI. Recently, extracellular vesicles (EVs) have been attracting strong research interest for use as natural drug delivery systems.
T. Tang, Bin Wang, Min Wu, Zuo-Lin Li, Ye Feng, Jingyuan Cao, D. Yin, Hong Liu, R. Tang, S. Crowley, L. Lv, Bi-Cheng Liu   +11 more
semanticscholar   +1 more source