Results 71 to 80 of about 77,313,502 (292)

The Human G Protein-Coupled ATP Receptor P2Y11 Is Associated With IL-10 Driven Macrophage Differentiation

Frontiers in Immunology, 2019
The G protein-coupled P2Y11 receptor is known to sense extracellular ATP during inflammatory and immune responses. The dinucleotide NAD+ has also been proposed to be a P2Y11 receptor ligand but its role is less clear. Here, we have examined for the first
Georg Gruenbacher, Hubert Gander, Andrea Rahm, Gabriele Dobler, Astrid Drasche, Jakob Troppmair, Walter Nussbaumer, Martin Thurnher   +7 more
doaj   +1 more source

The Generation of an Engineered Interleukin-10 Protein With Improved Stability and Biological Function

Frontiers in Immunology, 2020
Interleukin-10 (IL-10) is an immunoregulatory cytokine that plays a pivotal role in modulating inflammation. IL-10 has inhibitory effects on proinflammatory cytokine production and function in vitro and in vivo; as such, IL-10 is viewed as a potential ...
Faisal Minshawi, Faisal Minshawi, Sebastian Lanvermann, Edward McKenzie, Rebecca Jeffery, Kevin Couper, Stamatia Papoutsopoulou, Stamatia Papoutsopoulou, Axel Roers, Werner Muller   +9 more
doaj   +1 more source

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

Mechanisms by which interleukin-4 suppresses inflammatory cytokine production by activated human monocytes [PDF]

, 2011
Improving understanding of how inflammatory responses by monocytes and macrophages are regulated may aid in the development of more targeted therapies for chronic inflammatory disease.
Woodward, Eleanor
core  

Polymorphism of FcyRIIIA-l58F/V and promotion region of IL-10 genes in systemic lupus erythematosus in Kazakhs

Терапевтический архив, 2003
Aim. To assess the role of allele polymorphism of genes FcyRlH and IL-10 in systemic lupus erythematosus (SLR) in a homogeneous (stratified by nationality) Kazakh population sample. Material and methods.
I A Guseva, Zh E Omarbekova, V A Myakotkin   +2 more
doaj  

Social Functioning Within the First Years After Pediatric Brain Tumor Diagnosis and the Relationship With Family Psychosocial Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben, Marisa H. Huisman, Martha A. Grootenhuis, Femke K. Aarsen, Marita Partanen   +4 more
wiley   +1 more source

An intracytoplasmic IL-10 receptor variant permits rapid reduction in STAT3 activation [PDF]

Genes & Immunity, 2011
Within the interleukin-10 receptor 1 (IL10R1) gene, two common variants are associated with certain diseases: single-nucleotide polymorphism 3 (SNP3), a serine-138 to glycine mutation is in linkage disequilibrium with SNP4, a glycine-330 to arginine mutation, both of which are considered loss-of-function alleles.
Finsterbusch, Michaela, Khare, Vineeta, Campregher, Christoph, Evstatiev, Rayko, Gasche, Christoph   +4 more
openaire   +2 more sources

IL-10: the master regulator of immunity to infection.

, 2008
IL-10 is an anti-inflammatory cytokine. During infection it inhibits the activity of Th1 cells, NK cells, and macrophages, all of which are required for optimal pathogen clearance but also contribute to tissue damage.
Couper, Kevin N, Riley, Eleanor M, Blount, Daniel G, Blount, Daniel G., Couper, Kevin N., Riley, Eleanor M.   +5 more
core   +1 more source

Dexmedetomidine activates the PKA/CREB pathway and inhibits proinflammatory factor expression through β2 adrenergic receptors

Immunity, Inflammation and Disease
Introduction Dexmedetomidine (DEX) is primarily utilized for sedation in the context of general anesthesia or intensive care. However, the exact regulatory mechanism by which DEX affects cytokines remains unclear.
Baocheng Zhang, Jie Shen
doaj   +1 more source