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IL-17/IL-17 receptor system in autoimmune disease: mechanisms and therapeutic potential
Clinical Science, 2012IL-17 (interleukin-17), a hallmark cytokine of Th17 (T-helper 17) cells, plays critical roles in host defence against bacterial and fungal infections, as well as in the pathogenesis of autoimmune diseases. The present review focuses on current knowledge of the regulation, functional mechanisms and targeting strategies of IL-17 in the context of ...
Shu, Zhu, Youcun, Qian
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The role of IL-17 and IL-17 receptor inhibitors in the management of generalized pustular psoriasis
Drugs of Today, 2019Generalized pustular psoriasis (GPP) is a severe psoriasis form that can be refractory to several systemic treatments. The role of interleukin (IL)-17/ T-helper 17 (Th17) axis inhibitors in the therapy of GPP is not fully established. The objective of this paper is to summarize the existing information on the efficacy and safety of secukinumab ...
K- M, Plachouri +2 more
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The Impact of IL-17 in Atherosclerosis
Current Medicinal Chemistry, 2017Atherosclerosis is a chronic vascular disease in which atherosclerotic plaques develop in the arterial wall. It is believed that inflammation plays a major role in atherosclerotic formation and progression. Thus, atherosclerosis can be considered as an inflammatory disease of the arterial vessel.
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In This Issue: The Multiple Facets of IL-17
International Reviews of Immunology, 2015This issue of International Reviews of Immunology hosts a recurring special topic focused on T17 cells. The authors discuss the biology of this cell subset, its regulation and plasticity, along with its pivotal role in the immune defense against fungi.
Adrian, Bot, Mauro, Rossi
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The role of IL-17 in joint destruction
Drug News & Perspectives, 2002Interleukin-17 (IL-17) is a recently cloned cytokine secreted by activated memory CD4(+) T cells and modulates the early stage of immune responses. IL-17 stimulates epithelial, endothelial and fibroblastic stromal cells to secrete several cytokines such as IL-6, IL-8 and granulocyte colony-stimulating factor, as well as prostoglandin E2.
Shigeru, Kotake, Naoyuki, Kamatani
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Role of IL-17 and IL-17 Family Cytokines on Tumor Development
2012Anticancer immune responses restrain tumor progression, but persistent immune activation can induce chronic inflammation that contributes to tumor development. The IL-17 family of cytokines comprises six family members (IL-17A to IL-17F) that all contribute to tissue inflammation.
Frédérique Végran +2 more
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Blood, 2011
In this issue of Blood , the functional attributes of human Vγ9Vδ2 T cells are firmly extended to the secretion of the proinflammatory cytokine IL-17.[1][1] Over the past 5 years, immunology has been marked by intense investigation of the production of IL-17 by various populations of T cells ...
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In this issue of Blood , the functional attributes of human Vγ9Vδ2 T cells are firmly extended to the secretion of the proinflammatory cytokine IL-17.[1][1] Over the past 5 years, immunology has been marked by intense investigation of the production of IL-17 by various populations of T cells ...
openaire +2 more sources