Results 261 to 270 of about 1,561,364 (334)

Renal IL-17 activity in candidiasis [PDF]

Nature Reviews Nephrology, 2018
openaire   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Neutrophil-macrophage crosstalk via NETs-IL-17/VEGF/S100A9 axis promotes hepatocellular carcinoma progression. [PDF]

J Exp Clin Cancer Res
Wu R, Wu R, Kong X, Wang X, Duan Y, Cao S, Yu S, Zhao Y, Li S, Zhou J, Duan L.   +10 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

IL-17-producing γδ T cells in the tumor microenvironment promote radioresistance in mice. [PDF]

J Clin Invest
Deng Y, Liu X, Yang X, Wei W, Wang J, Yang Z, Sun Y, Hu Y, Zhang H, Wang Y, Zhang Z, Wen L, Huang F, Yang K, Wan C.   +14 more
europepmc   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Licoisoflavone B alleviates psoriasis via SCD1-targeted lipid metabolism reprogramming and suppression of Th17/IL-17-mediated inflammation. [PDF]

Front Pharmacol
Liu Y, Wong VKW, Liu J, Jiang M, Yang C, He X, Wang J, Zhang L, Xiong A, Ran Q, Li X, Wang K, Li M, Song P, Jin L, Li G.   +15 more
europepmc   +1 more source

Stabilität und Plastizität der IL-17-Expression in T H 17-Zellen und die regulatorische Funktion von IL-17 in einem Infektionsmodell

, 2011
A Taubner
openalex   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Intestinal homeostasis alteration toward mucosal inflammation with blocking IL-17 in psoriasis patients: a case series. [PDF]

Transl Gastroenterol Hepatol
Shimodaira Y, Fukuda S, Takahashi S, Yamakawa T, Kono M, Iijima K.   +5 more
europepmc   +1 more source