Results 91 to 100 of about 76,477,355 (241)
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
Journal of Experimental Pharmacology, 2021 Hasan Tahir,1,2 Swetha Byravan,3 Armin Fardanesh,4 Arumugam Moorthy3,5 1Department of Rheumatology, Royal Free London NHS Foundation Trust, London, UK; 2Division of Medicine, University College London, London, UK; 3Department of Rheumatology, University ...
Tahir H +3 more
doaj
NAIL PSORIASIS AS A DIFFICULT-TO-TREAT AREA: COMPARATIVE EVIDENCE FOR IL-17 AND IL-23 INHIBITORS
Nail psoriasis is a frequent and clinically relevant manifestation of psoriasis, affecting a substantial proportion of patients with plaque psoriasis and psoriatic arthritis.
Napiórkowska, Katarzyna +4 more
core +1 more source
RNA‐related functions of BRCA2 in transcription, replication, and genome stability
FEBS Letters, EarlyView.Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda +2 more
wiley +1 more source
Ulusal Romatoloji DergisiObjective: With increasing use of biologics targeting multiple pathways in treatment-resistant spondyloarthritis (SpA), understanding patient characteristics has become crucial.
Gözde Duygu İşbilir +10 more
doaj +1 more source
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
Frontiers in MedicinePyoderma gangrenosum (PG) is a rare, rapidly progressive, non-infectious neutrophilic dermatosis characterized by severely painful ulcers. Its pathogenesis may be attributed to genetic factors, autoimmune dysfunction, and neutrophil disorders ...
Wang Liwei +3 more
doaj +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Dermatology and TherapyIntroduction Patients with psoriasis (PsO) and permanent spinal cord injuries (SCI) resulting in paraplegia and tetraplegia may experience a higher rate of infections compared to patients with PsO without SCI.
Giovanni Damiani +6 more
doaj +1 more source