Results 71 to 80 of about 76,477,355 (241)

Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation by inhibiting IL-12 and IFNγ  production [PDF]

, 2009
IL-23/IL-17-induced neutrophil recruitment plays a pivotal role in rheumatoid arthritis (RA). However, the mechanism of the neutrophil recruitment is obscure.
Foo Y. Liew, Ferreira, Sergio H., Cunha, Fernando Q., Cunha, Thiago Mattar, Fernando Q. Cunha, Ferreira, Seérgio Henrique, Karla S. S. Fernandes, Silvio M. Vieira, Waldiceu A. Verri, McInnes, Iain B., Sergio H. Ferreira, Lemos, Henrique Paula, Liew, Foo Y., Thiago M. Cunha, Souto, Fabrício Oliveira, Renata Grespan, Manfredo Vieira, Silvio, Cunha, Thiago M., Souto, Fabricio O., Lemos, Henrique P., Fabricio O. Souto, Vieira, Silvio M., Fernandes, Karla S. S., Henrique P. Lemos, Verri, Waldiceu A., Grespan, Renata, Fernandes, Karla S., Cunha, Fernando Queiroz, Iain B. McInnes, VERRI JR., Waldiceu A.   +29 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Interleukin inhibitors and the associated risk of candidiasis

Frontiers in Immunology
Interleukins (ILs) are vital in regulating the immune system, enabling to combat fungal diseases like candidiasis effectively. Their inhibition may cause enhanced susceptibility to infection.
Sabir Khan, Hazrat Bilal, Muhammad Nadeem Khan, Wenjie Fang, Wenqiang Chang, Bin Yin, Ning-jing Song, Zhongrong Liu, Dongxing Zhang, Dongxing Zhang, Fen Yao, Xun Wang, Qian Wang, Lin Cai, Bing Hou, Jiayue Wang, Chunyan Mao, Lingxi Liu, Yuebin Zeng, Yuebin Zeng   +19 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Targeting the Pathway or the Cytokine? Network Meta-Analysis of JAK1 vs. IL-17 Inhibitors in Hidradenitis Suppurativa

Protocol for a systematic review and Bayesian Network Meta-Analysis (NMA) comparing the efficacy of oral JAK1 inhibitors (povorcitinib, upadacitinib) versus IL-17 inhibitors (bimekizumab, secukinumab) and adalimumab in moderate-to-severe Hidradenitis ...
Alexander Jalali, Ayhan Ozan Ozdemir
core   +2 more sources

DataSheet_1_Short-term risk and long-term incidence rate of infection and malignancy with IL-17 and IL-23 inhibitors in adult patients with psoriasis and psoriatic arthritis: a systematic review and meta-analysis.docx

, 2023
The risk of infection and malignancy may be a concern for patients with psoriasis receiving interleukin (IL)-17 and IL-23 inhibitors, particularly with long-term treatments.
Linghong Guo (4011794), Shuwei Wu (9741779), Yuanyuan Xu (163995), Lihua Yang (470364), Xian Jiang (201042)   +4 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Impact of Disease Activity-Guided Dose Reduction on IL-17 and IL-23 Inhibitors in Psoriasis: A Real-World Assessment of Efficacy, Safety, and Economic Benefits

Dermatology Practical & Conceptual
Introduction: Psoriasis is a chronic inflammatory multisystem disease for which IL-17 and IL-23 inhibitors have transformed treatment. However, high costs, and the possibility of overtreatment in patients with excellent and sustained responses have ...
Edoardo Cammarata, Chiara Airoldi, Jacopo Colombo, Andrealuna Ucciero, Luca Mastorino, Veronica Arese, Lorenza Burzi, Franco Castelli, Massimo Chiarpenello, Francesca Graziola, Claudia Leporati, Michela Ortoncelli, Pella Paolo, Ginevra Pertusi, Alessia Pisterna, Pietro Quaglino, Simone Ribero, Gianluca Rossotto, Rossana Tiberio, Paolo Dapavo, Paola Savoia   +20 more
doaj   +1 more source

IL-17/IFN-γ受容体遺伝子ダブル欠損NODマウスにおける糖尿病発症抑制 [PDF]

, 2013
Aims/hypothesis T helper type (Th) 17 cells have been shown to play important roles in mouse models of several autoimmune diseases that have been classified as Th1 diseases. In the NOD mouse, the relevance of Th1 and Th17 is controversial, because single-
厨, 源平
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source