Results 51 to 60 of about 76,477,355 (241)

Assessment of Primary Malignancy Risk after Initiation of Biologic Therapy in Patients with Psoriasis

JID Innovations
Limited evidence exists regarding the long-term oncologic safety of biologic therapies, particularly IL-17 inhibitors and IL-23 inhibitors, in the management of psoriasis.
Chunghwan Ro, Ana Ormaza Vera, Waleed Adawi, Alexander Yap, Clinton W. Enos   +4 more
doaj   +1 more source

The Impact of Tenapanor on Body Composition and Blood Pressure in Peritoneal Dialysis Patients: A Pilot Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Instruction Tenapanor potentially affects fluid volume and blood pressure. This study explored its effects on these parameters in patients undergoing peritoneal dialysis (PD). Methods We conducted a single‐arm, prospective observational study that enrolled 10 patients on PD with hyperphosphatemia who were newly initiated on tenapanor.
Shun Yoshida, Kengo Asahina, Keiichi Osano, Natsumi Saegusa, Kohei Yamamura, Kie Ohkoshi, Miho Shikata, Toshihisa Ishii, Makiko Konishi, Kazuya Takahashi, Kohei Uchimura, Ayumu Nakashima   +11 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Real-World Dose Adjustment and Switching of Interleukin-17/23 Inhibitors for Thai Psoriasis

Dermatology Research and Practice
Interleukin (IL)-17 and IL-23 inhibitors have transformed psoriasis care, delivering high clearance rates and quality-of-life gains. Nevertheless, inadequate response or adverse events can lead to treatment discontinuation or biologic switching.
Chayada Chaiyabutr, Teerapat Paringkarn, Thanakorn Woramongkol, Thrit Hutachoke, Narumol Silpa-Archa, Leena Chularojanamontri, Chanisada Wongpraparut   +6 more
doaj   +1 more source

A Review of Interleukin-23/Interleukin-17 Inhibitor Exposure during Pregnancy in Patients with Psoriasis

Clinical Dermatology Review
Psoriasis is an immune cell-mediated chronic relapsing inflammatory skin disease that often develops during the reproductive years of women. The treatment of psoriasis during pregnancy is challenging as remarkable changes occur in the maternal body, and ...
Nirali Doshi, Bijal Prajapati, Lavanya Selvaraj   +2 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Supplemental Materials: Hair Loss Associated With IL-17 and IL-23 Inhibitors: A Systematic Review

Supplemental materials for "Hair Loss Associated With IL-17 and IL-23 Inhibitors: A Systematic Review" including search strategy (Table S1), PRISMA flowchart (Figure S1), and mechanism diagram (Figure S2)
Gupta, Sana
core   +1 more source

The role of IL-23 and the use IL-23 inhibitors in psoriatic arthritis

, 2022
Background: Psoriatic arthritis (PsA) is a chronic inflammatory arthritis characterised by musculoskeletal and extra-articular manifestations, most notably psoriasis.
George E. Fragoulis, Siebert, Stefan, Fragoulis, George E., Stefan Siebert   +3 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Supplemental Files for "Increased risk of nonmelanoma skin cancer with cyclosporine, methotrexate, TNF-α inhibitors, and interleukin (IL)-12/23 inhibitor, but not with IL-17 or IL-23 inhibitors in psoriasis patients"

Background: People with psoriasis are at increased risk for nonmelanoma skin cancers (NMSC) and melanoma. Conventional immunosuppressants and TNF-α inhibitors may further increase skin malignancy risk, while the risks of other biologics are less clear.
Woodie, Brad
core   +1 more source