Results 111 to 120 of about 72,835,347 (270)

IL‐1, IL‐18, and IL‐33 families of cytokines

, 2008
SUMMARY: The interleukin-1 (IL-1), IL-18, and IL-33 families of cytokines are related by mechanism of origin, receptor structure, and signal transduction pathways utilized.
Cem Gabay, Palmer-Lourenco, Gaby, William P. Arend, Arend, William P., Gabay, Cem, Gaby Palmer   +5 more
core   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Niobium uptake and release by bacterial ferric ion binding protein [PDF]

, 2010
Ferric ion binding proteins (Fbps) transport FeIII across the periplasm and are vital for the virulence of many Gram negative bacteria. Iron(III) is tightly bound in a hinged binding cleft with octahedral coordination geometry involving binding to ...
Dominic Campopiano, Sadler, P. J., Harvey, Ian, Ian Harvey, Shi Y, Campopiano D, Peter J. Sadler, Shi, Yanbo, Harvey I, Campopiano, Dominic, Sadler PJ, Yanbo Shi, Sadler, Peter J   +12 more
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Contribution of fibronectin-binding protein to pathogenesis of Streptococcus suis serotype 2 [PDF]

, 2002
In the present study we investigated the role of the fibronectin (FN)- and fibrinogen (FGN)-binding protein (FBPS) in the pathogenesis of Streptococcus suis serotype 2 in piglets. The complete gene encoding FBPS from S.
Dijkstra, J., Smit, H.E., Verhaar, R., Alphen, L., van, Greeff, A., de, Robin Verhaar, Loek van Alphen, Herma Buys, Buys, H., Janny Dijkstra, Hilde E. Smith, Astrid de Greeff   +11 more
core   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Suppression of multiple mouse models of refractory malignancies by reprogramming IL-18 ligand-receptor interaction

Nature Communications
Achieving a cure is an urgent need for patients with advanced solid tumors. Here, we discover that oncolytic virus (OV) infection enhances IL-18 receptor expression but fails to increase IL-18 ligand expression.
Zhen Fan, Ying Liu, Xueying Lin, Jifu Zhang, Jiehong Chen, Shiming Yi, Cheng Hu, Xincheng Liu, Cui Guo, Cuiying Xu, Xiaoyu Chen, Xuyan Tian, Xuanming Liang, Yang Liu, Linyi Hu, Shanyu Huang, Li Guo, Wenbo Zhu, Jun Hu, Guangmei Yan, Yuan Lin, Jing Cai, Jiankai Liang   +22 more
doaj   +1 more source

Durable antitumor response via an oncolytic virus encoding decoy-resistant IL-18

Journal for ImmunoTherapy of Cancer
Background Interleukin-18 (IL-18), or interferon (IFN)-γ-inducing factor, potentiates T helper 1 and natural killer cell activation as well as CD8+ T-cell proliferation.
Yu Liu, Yichi Zhang, Yayi Hou, Yan Cheng, Mengyu Zhang, Yuanhui Zhao, Dongge Xu, Weikang Sun, Yuqing Miao, Susu He, Dwayne Stupack, Erguang Li   +11 more
doaj   +1 more source

The Evaluation of Plasma and Leukocytic IL-37 Expression in Early Inflammation in Patients with Acute ST-Segment Elevation Myocardial Infarction after PCI

Mediators of Inflammation, 2015
Objective. Acute ST-segment elevation myocardial infarction (ASTEMI) is accompanied by increased expression of inflammation and decreased expression of anti-inflammation.
Xin Wang, Xiangna Cai, Lan Chen, Duanmin Xu, Jilin Li   +4 more
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source