Results 121 to 130 of about 741,206 (288)

Durable antitumor response via an oncolytic virus encoding decoy-resistant IL-18

Journal for ImmunoTherapy of Cancer
Background Interleukin-18 (IL-18), or interferon (IFN)-γ-inducing factor, potentiates T helper 1 and natural killer cell activation as well as CD8+ T-cell proliferation.
Yu Liu, Yichi Zhang, Yayi Hou, Yan Cheng, Mengyu Zhang, Yuanhui Zhao, Dongge Xu, Weikang Sun, Yuqing Miao, Susu He, Dwayne Stupack, Erguang Li   +11 more
doaj   +1 more source

Enhanced Expression of IL-18 and IL-18BP in Plasma of Patients with Eczema: Altered Expression of IL-18BP and IL-18 Receptor on Mast Cells

Mediators of Inflammation, 2017
IL-18 has been found to be associated with eczema. However, little is known of the role of IL-18 binding protein (BP) and IL-18 receptor (R) in eczema.
Yalin Hu, Junling Wang, Huiyun Zhang, Hua Xie, Weiwei Song, Qijun Jiang, Nan Zhao, Shaoheng He   +7 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Simultaneous Increase in Serum Levels of IL-37 and IL-18 Binding Protein In Low-Grade and High-Grade Brain Tumors. [PDF]

Asian Pac J Cancer Prev, 2022
Haghshenas MR, Saffarian A, Khademolhosseini A, Dehghanian A, Ghaderi A, Sotoodeh Jahromi A.   +5 more
europepmc   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

TBP-1 (TAT BINDING PROTEIN-1) IN THE CONTROL OF CELL PROLIFERATION: FUNCTIONAL RELATIONSHIP WITH THE AKT/PKB SIGNALING PATHWAY [PDF]

, 2011
TBP-1/Tat-Binding Protein 1 (also named Rpt-5, S6a or PSMC3) is a multifunctional protein, originally identified as a regulator of HIV-1-Tat mediated transcription.
Festa, Luisa
core  

Protein-carbohydrate interactions during fertilization [PDF]

, 1998
Interaction between gametes during fertilization is at least in part regulated by carbohydrate moieties of the zona pellucida (ZP) and carbohydrate binding proteins of the sperm surface. This review focuses on the protein-carbohydrate interactions during
Plendl, J., Sinowatz, Fred, Kolle, S.
core   +1 more source

THE INFLUENCE OF PATHOGENETIC THERAPY ON THE LEVER OF CYTOKINES IN PATIENTS WITH ACUTE BRUCELLOSIS

Инфекция и иммунитет, 2017
The purpose of the study was to determine the level of proinflammatory cytokines: IL-12, IL-8 and IFNγ, neopterin and lipopolysaccharide-binding protein in the serum of patients with acute brucellosis before and after antibiotic therapy.
N. I. Kovalevich, N. S. Sarkisyan, E. L. Rakitina, V. A. Galyas, I. V. Sannikova, O. V. Makhinya   +5 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Functional domains of the influenza A virus PB2 protein:identification of NP- and PB1-binding sites [PDF]

, 2004
Influenza virus genomic RNA segments are packaged into ribonucleoprotein (RNP) structures by the PB1, PB2, and PA subunits of an RNA polymerase and a single-strand RNA-binding nucleoprotein (NP).
Poole, Emma, Digard, Paul, Medcalf, Liz, Elton, Debra, Poole, Emma L   +4 more
core   +1 more source