Results 121 to 130 of about 72,835,347 (270)

A role for IL-18 in protective immunity against Mycobacterium tuberculosis.

, 2009
Tuberculosis remains the most hazardous bacterial infection worldwide. The causative agent, Mycobacterium tuberculosis, is a facultative intracellular pathogen of resting MPhi.
Hagens, Kristine, Bärbel Raupach, Stefan H. E. Kaufmann, Daniel Korbel, Schneider, Bianca E, Raupach, Bärbel, Enders, Jana, Jana Enders, Markus Koch, Kaufmann, Stefan HE, Hans-Willi Mittrücker, Bianca E. Schneider, Ulrich E. Schaible, Korbel, Daniel, Schaible, Ulrich E, Mittrücker, Hans-Willi, Koch, Markus, Kristine Hagens   +17 more
core   +1 more source

Enhanced Expression of IL-18 and IL-18BP in Plasma of Patients with Eczema: Altered Expression of IL-18BP and IL-18 Receptor on Mast Cells

Mediators of Inflammation, 2017
IL-18 has been found to be associated with eczema. However, little is known of the role of IL-18 binding protein (BP) and IL-18 receptor (R) in eczema.
Yalin Hu, Junling Wang, Huiyun Zhang, Hua Xie, Weiwei Song, Qijun Jiang, Nan Zhao, Shaoheng He   +7 more
doaj   +1 more source

Immunomodulatory IL-18 binding protein is produced by prostate cancer cells and its levels in urine and serum correlate with tumor status

International Journal of Cancer, 2010
Cytokines may play a role in the initiation and progression of prostate cancer. A cytokine antibody array was previously applied to prostatic fluid obtained from patients with prostate cancer, and interleukin 18 binding protein (IL‐18BP), a potent ...
K. Fujita, C. Ewing, William B. Isaacs, C. Pavlovich   +3 more
semanticscholar   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Subtype‐associated complexity and prognostic significance of the NLRP3 inflammasome landscape in pancreatic neoplasms

The Journal of Pathology: Clinical Research
Intraductal papillary mucinous neoplasm (IPMN) can progress into malignant pancreatic cancer, posing challenges in accurately assessing the risk of malignancy.
Kristóf Németh, Eszter Mezei, Justína Vörös, Katalin Borka, Adrián Pesti, István Kenessey, András Kiss, András Budai   +7 more
doaj   +1 more source

Targeting highly attenuated IL-18 to PD-1 for enhanced anti-tumor activity

Frontiers in Immunology
Checkpoint inhibitors targeting the PD-1/PD-L1 axis have revolutionized cancer immunotherapy, yet response rates remain limited. To enhance efficacy, next-generation approaches target T cell-activating cytokines to PD-1 via antibodies.
Xueyuan Zhou, Felix Klaus Geyer, Jeffrey Takimoto, Harald Kolmar, Harald Kolmar, Brian Rabinovich   +5 more
doaj   +1 more source

Cloning and characterization of giant panda (Ailuropoda melanoleuca) IL-18 binding protein

Research in Veterinary Science, 2016
The giant panda (Ailuropoda melanoleuca) is an endangered species. Interleukin-18 (IL-18) plays an important role in the innate and adaptive immune responses by inducing IFN-γ. IL-18 has been implicated in the pathogenesis of various diseases. IL-18 binding protein (IL-18BP) is an intrinsic inhibitor of IL-18 that possesses higher affinity to IL-18. In
Yan, Yue, Deng, Jiabo, Niu, Lili, Wang, Qiang, Yu, Jianqiu, Shao, Huanhuan, Cao, Qinghua, Zhang, Yizheng, Tan, Xuemei   +8 more
openaire   +2 more sources

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Human Papillomavirus E7 oncoprotein increases production of the anti-inflammatory IL-18 binding protein (IL-18BP) in keratinocytes [PDF]

, 2014
Human papillomavirus can successfully evade the host immune response to establish a persistent infection. We show here that expression of the E7 oncoprotein in primary human keratinocytes results in increased production of IL-18 binding protein (IL-18BP).
Doble, R, Wasson, CW, Richards, KH, Wittmann, M, Blair, GE, Macdonald, A, Haider, M   +6 more
core   +1 more source