Results 241 to 250 of about 741,206 (288)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

NLR Inflammasomes in Viral Infections: From Molecular Mechanisms to Therapeutic Interventions. [PDF]

Viruses
Hou S, Shen X, Sun D, An Y, Zhou Y, Sun X, Wang S, Liu X, Zhu M, Zhao S, Liu Z, Wu X, Liu R.   +12 more
europepmc   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Molecular mechanism of propofol in reducing kidney injury induced by autologous orthotopic liver transplantation. [PDF]

Front Immunol
Jin G, Tang X, Gu B, Zhou J.
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Heat Shock Proteins in Medically Relevant Fungal Pathogens: From Molecular Chaperones to Virulence Factors and Therapeutic Targets. [PDF]

J Fungi (Basel)
Padró-Villegas L, Mora-Montes HM.
europepmc   +1 more source

Integrative Computational Prediction Strategy for Antibody-Antigen Binding: A Case Study on Interleukin-1 Beta. [PDF]

J Chem Inf Model
Aygen ME, Uyar A.
europepmc   +1 more source

Human resistin is critical to activation of the NLRP3 inflammasome in macrophages. [PDF]

PLoS One
Kariyawasam U, Lam W, Skinner J, Chakrabarti R, Cox A, Hassoun PM, Lin Q, Johns RA.   +7 more
europepmc   +1 more source

A chimeric trivalent Echovirus vaccine designed by loop substitution elicits cross-neutralizing immunity against serotypes 11, 18, and 30. [PDF]

J Virol
Jiang S, Cui J, Sun T, Li J, Li H, Chen T, Wu J, Zheng Z, Xia J, Wu C, Wu J.   +10 more
europepmc   +1 more source

NLR inflammasome pathways: key targets for pathogenesis and therapy of metabolic diseases. [PDF]

Front Immunol
Zhou J, Yang R, Zhu W, He Z, Ma Y, Feng Z, Yu L.   +6 more
europepmc   +1 more source