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Neutralization of IL-18 by IL-18 binding protein ameliorates bleomycin-induced pulmonary fibrosis via inhibition of epithelial-mesenchymal transition

Biochemical and Biophysical Research Communications, 2019
Idiopathic pulmonary fibrosis (IPF) is a fatal parenchymal lung disease with limited effective therapies. Interleukin (IL)-18 belongs to a rather large IL-1 gene family and is a proinflammatory cytokine, which acts in both acquired and innate immunity.
Li-Ming, Zhang   +6 more
openaire   +2 more sources

Ratios between the Levels of IL-18, Free IL-18, and IL-1β-Binding Protein Depending on the Severity and Outcome of COVID-19

Bulletin of Experimental Biology and Medicine
In 89 patients with COVID-19, the ratios between IL-18, free IL-18, and IL-18-binding protein (IL-18BP) were analyzed depending on severity and outcome of the disease. At admission to the hospital, the levels of IL-18 and free IL-18 were significantly higher than 3 months after discharge from the hospital, the levels IL-18BP of being almost the same ...
A A, Korotaeva   +5 more
openaire   +2 more sources

Evidence for the presence of interleukin (IL)-18, IL-18 receptor and IL-18 binding protein expression in the human endometrium.

Fertility and Sterility, 2001
O Yoshino   +5 more
openaire   +1 more source

Computational prediction of protein–protein binding affinities

Wiley Interdisciplinary Reviews: Computational Molecular Science, 2020
Martin Zacharias
exaly  

DeepDTAF: a deep learning method to predict protein–ligand binding affinity

Briefings in Bioinformatics, 2021
, Yaohang Li, Kaili Wang
exaly  

IL-18 binding protein as a noble biomarker for idiopathic pulmonary fibrosis

Idiopathic interstitial pneumonias, 2020
Yu Nakanisihi   +10 more
openaire   +1 more source

Blockade of IL-18 via long-acting IL-18 binding protein attenuates experimental diet-induced cholestatic disease

Journal of Hepatology, 2023
Dong-Hyun Kim   +9 more
openaire   +1 more source

Periplasmic binding proteins: a versatile superfamily for protein engineering

Current Opinion in Structural Biology, 2004
Homme Hellinga, Mary A Dwyer
exaly  

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