Results 171 to 180 of about 1,832,666 (293)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Low-Dose IL-2 Attenuates Neuropathic Pain via Treg Expansion in Rats. [PDF]

J Pain Res
Zhao Y, Shen L, Huang Y.
europepmc   +1 more source

Data record for main results of: Adaptive study of IL-2 dose on regulatory T cells in Type 1 Diabetes (DILT1D)

, 2016
Frank Waldron-Lynch
openalex   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

In Silico tool for predicting, designing and scanning IL-2 inducing peptides. [PDF]

Sci Rep
Mehta NK, Lathwal A, Kumar R, Kaur D, Raghava GPS.   +4 more
europepmc   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Soquelitinib inhibition of IL-2-inducible T cell kinase ameliorates lung damage in murine models of systemic sclerosis. [PDF]

Arthritis Res Ther
Boleto G, Cauvet A, Guignabert C, Thuillet R, Ottaviani M, Tu L, Hsu LY, Rosenbaum JT, Miller RA, Allanore Y.   +9 more
europepmc   +1 more source

COX-2 contributes to LPS-induced Stat3 activation and IL-6 production in microglial cells.

, 2018
Jie Zhu, Shuzhen Li, Yue Zhang, Guixia Ding, Chunhua Zhu, Songming Huang, Aihua Zhang, Zhanjun Jia, Mei Li   +8 more
openalex   +1 more source

The IL-2 Receptor Promotes Proliferation, bcl-2 and bcl-x Induction, But Not Cell Viability Through the Adapter Molecule Shc [PDF]

, 1998
James D. Lord, Bryan C. McIntosh, Philip D. Greenberg, Brad H. Nelson   +3 more
openalex   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source