Nigella sativa oil protects against cadmium-induced intestinal toxicity via promotion of anti-inflammatory mechanisms, mucin expression and microbiota integrity [PDF]
Avicenna Journal of Phytomedicine, 2022 Objective: This study examined the protective effects of Nigella sativa oil (NSO) on cadmium (Cd)-induced alterations affecting gut morphology and microbiota composition, as well as the involvement of mucus glycoprotein (MUC2) and immuno-inflammatory ...
Akinleye Akinrinde +2 more
doaj +1 more source
Zhongliu Fangzhi Yanjiu, 2021 Objective To investigate the preventive and inhibitory effects of tumor cell lysate(TCL) combined with IL-2 on melanoma and the potential immune mechanism. Methods The B16F10 melanoma TCL cell were prepared using an ultrasonic disruptor.
SI Yiran +6 more
doaj +1 more source
The IL-2 – IL-2 receptor pathway: Key to understanding multiple sclerosis
Journal of Translational Autoimmunity, 2021 The development, progression, diagnosis and treatment of autoimmune diseases, such as multiple sclerosis (MS), are convoluted processes which remain incompletely understood. Multiple studies demonstrated that the interleukin (IL)-2 - IL-2 receptor (IL-2R) pathway plays a pivotal role within these processes.
Daphne Peerlings +2 more
openaire +5 more sources
Immunomodulatory Effects of IL-2 and IL-15; Implications for Cancer Immunotherapy
Cancers, 2020 Simple Summary Emerging knowledge of the two type I cytokine family members IL-2 and IL-15 has led to critical therapeutic implications for cancer treatment. Here we discuss the distinct roles of IL-2 and IL-15 in activating various functions of T and NK
Ying Yang, A. Lundqvist
semanticscholar +1 more source
Regulation of T cell differentiation by the AP-1 transcription factor JunB
Immunological Medicine, 2021 JunB, a component of the activator protein-1 (AP-1) transcription factor, is known to exhibit an important role in bone formation and bone marrow cell proliferation. During T helper type 2 (Th2) cell differentiation, JunB contributes to the regulation of
Takaharu Katagiri +3 more
doaj +1 more source
Long-term effects of intermittent IL-2 in HIV infection: extended follow-up of the INSIGHT STALWART Study [PDF]
, 2012 BACKGROUND The Study of Aldesleukin with and without Antiretroviral Therapy (STALWART) was designed to evaluate whether intermittent IL-2 alone or with peri-cycle ART increased CD4+ cell counts (and so delayed initiation of ART) in HIV infected ...
Babiker, Abdel +8 more
core +5 more sources
Interleukine-2 serum level in breast cancer patients [PDF]
Caspian Journal of Internal Medicine, 2023 Background: Breast cancer is a form of cancer that typically affects females. In general, cancer is caused by an imbalance between oncogene and supressor gene factors, including immunity factors against cancer cells. This study aims to compare the levels
Tutik Harjianti +4 more
doaj
Acta Pharmaceutica, 2021 Interleukin-2 (IL-2) is involved in the activation and differentiation of T-helper cells. Uncontrolled activated T cells play a key role in the pathophysiology by stimulating inflammation and autoimmune diseases like arthritis, psoriasis and Crohn’s ...
Halim Sobia Ahsan +4 more
doaj +1 more source
IL-2 Therapy Diminishes Renal Inflammation and the Activity of Kidney-Infiltrating CD4+ T Cells in Murine Lupus Nephritis [PDF]
, 2019 An acquired deficiency of interleukin-2 (IL-2) and related disturbances in regulatory T cell (Treg) homeostasis play an important role in the pathogenesis of systemic lupus erythematosus (SLE).
Burmester, Gerd-Rüdiger +8 more
core +2 more sources
Evaluation Of Cytokines Changes In Patients Infected With Giardia lamblia In Comparison With Healthy Subjects [PDF]
پیاورد سلامت, 2012 Background and Aim: Human Giardisis infection is caused by the flagellate protozoa. Giardia lamblia, which lives in the small intestine, causing damage and may also cause gastrointestinal symptoms.
Mitra Zarebavani +3 more
doaj +1 more source