Results 11 to 20 of about 1,832,666 (293)
The IL-2 – IL-2 receptor pathway: Key to understanding multiple sclerosis
Journal of Translational Autoimmunity, 2021 The development, progression, diagnosis and treatment of autoimmune diseases, such as multiple sclerosis (MS), are convoluted processes which remain incompletely understood. Multiple studies demonstrated that the interleukin (IL)-2 - IL-2 receptor (IL-2R) pathway plays a pivotal role within these processes.
Daphne Peerlings +2 more
openaire +4 more sources
Tạp chí Khoa học Đại học Mở Thành phố Hồ Chí Minh - Kỹ thuật và Công nghệ, 2022 Liệu pháp miễn dịch được coi là một phương pháp đầy hứa hẹn trong điều trị ung thư. Tế bào miễn dịch của bệnh nhân được phân lập, cảm ứng tăng sinh, biến đổi thành các tế bào chức năng khác nhau và sau đó được đưa trở lại người bệnh. Các tế bào miễn dịch
Phùng Thị Việt Anh +2 more
doaj +1 more source
IL-2/anti-IL-2 mAb immunocomplexes: A renascence of IL-2 in cancer immunotherapy? [PDF]
OncoImmunology, 2015 The in vivo biological activity of IL-2 can be dramatically increased by complexing with anti-IL-2 mAb. Moreover, IL-2/anti-IL-2 mAb immunocomplexes selectively stimulate different subsets of immune cells, depending on the clone of anti-IL-2 mAb that is used.
Tomala, J. (Jakub), Kovář, M. (Marek)
openaire +3 more sources
IL-2 coordinates IL-2–producing and regulatory T cell interplay [PDF]
Journal of Experimental Medicine, 2013 Many species of bacteria use quorum sensing to sense the amount of secreted metabolites and to adapt their growth according to their population density. We asked whether similar mechanisms would operate in lymphocyte homeostasis. We investigated the regulation of the size of interleukin-2 (IL-2)–producing CD4+ T cell (IL-2p) pool using different IL-2 ...
Amado, Inês F +8 more
openaire +3 more sources
Interleukin-2 signalling is modulated by a labile disulfide bond in the CD132 chain of its receptor [PDF]
Open Biology, 2012 Certain disulfide bonds present in leucocyte membrane proteins are labile and can be reduced in inflammation. This can cause structural changes that result in downstream functional effects, for example, in integrin activation.
Clive Metcalfe +2 more
doaj +1 more source
Proinflammatory Cytokines and Its Correlation with Liver Injury
The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy, 2022 Background: A persistent infection of hepatitis B virus (HBV) can cause liver cirrhosis and hepatocarcinoma even though the virus itself is non-cytopathic and does not cause cell injury.
Tri Nugraha Susilawati +2 more
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Nigella sativa oil protects against cadmium-induced intestinal toxicity via promotion of anti-inflammatory mechanisms, mucin expression and microbiota integrity [PDF]
Avicenna Journal of Phytomedicine, 2022 Objective: This study examined the protective effects of Nigella sativa oil (NSO) on cadmium (Cd)-induced alterations affecting gut morphology and microbiota composition, as well as the involvement of mucus glycoprotein (MUC2) and immuno-inflammatory ...
Akinleye Akinrinde +2 more
doaj +1 more source
Mathematical Biosciences and Engineering, 2016 Understanding the global interaction dynamics between tumor and the immunesystem plays a key role in the advancement of cancer therapy.Bunimovich-Mendrazitsky et al.
K. E. Starkov +1 more
doaj +1 more source
OncoImmunology, 2022 Intratumoral immunotherapies are entering clinical use but concerns remain regarding their effects on non-injected tumors. Here, we studied the impact of local treatment with an adenovirus coding for TNFa and IL-2 on systemic antitumor response in ...
Dafne C. A. Quixabeira +11 more
doaj +1 more source
Correlation of regulatory T cells in chronic lymphocytic leukemia characterized by high-affinity CD25 expression with serum IL-2 values, IGVH mutational status, Rai stage, and therapeutic lines [PDF]
Romanian Medical Journal, 2020 The impact of the importance of regulatory T cells (Treg) in chronic lymphocytic leukemia (CLL) is still controversial and no consensus has been reached on whether the effects generated by these cells are positive or negative in terms of tumor ...
Georgiana Ene +4 more
doaj +1 more source