Results 241 to 250 of about 116,073,120 (283)

PTPN1/PTPN2 inhibition improves NK cancer therapy by enhancing IL-2 and mitigating TGFβ1 responses. [PDF]

EMBO Rep
Feng CH, Peltier L, Chouleur T, DiPonzio M, Aubry I, Poirier AJ, Cordova ZM, Shen Y, Tabariès S, Cao X, Chen G, Bikfalvi A, Vidal SM, Siegel PM, Laneuville P, Tremblay ML.   +15 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Induction of high numbers of T_reg cells post treatment with anti-IL-2/IL-2 complex associates with alleviation of experimental psoriasis-like skin inflammation. [PDF]

BMC Immunol
Salman S, Khalil SM, Abdel-Latif AM, El Attar YA, Salem ML.   +4 more
europepmc   +1 more source

IL-2 mutein promotes antigen-specific transplant acceptance in mice through expansion of ST2⁺ regulatory T cells. [PDF]

Nat Commun
Ganchiku Y, Ribas GT, Lima K, Gassen RB, Liu K, Efe O, Griffith JW, Luster AD, Shriver Z, Babcock GJ, Rosales IA, LeGuern C, Borges TJ, Riella LV.   +13 more
europepmc   +1 more source

Neoadjuvant combined immunotherapy with intratumoral TransCon TLR7/8 Agonist and systemic TransCon IL-2 β/y or pembrolizumab in patients with locally advanced oral cancer-a monocentric experience. [PDF]

Cancer Immunol Immunother
Weber M, Trumet L, Lange F, Murk J, Schubert P, Alsamra H, Backhaus J, Corradini S, Kesting M, Müller S, Morris J, Haderlein M.   +11 more
europepmc   +1 more source

Soluble IL-2 receptor and memory Treg profiles differentiate early rheumatoid arthritis from undifferentiated arthritis at initial presentation. [PDF]

Front Immunol
Zi X, Shi Y, Zhao Y, Gao C, Wang C.
europepmc   +1 more source

Simultaneous TCR and IL-2 agonism selectively enhances epitope-specific CD8 T-cell responses during chronic viral infection. [PDF]

J Virol
Hashimoto M, Khan MA, Akhtar A, Agrewala JN, Freeman GJ, Girgis N, Zhang Y, Low S, Quayle SN, Suri A, Ahmed R.   +10 more
europepmc   +1 more source

Co-Expression of IL-2 Enhances the Efficacy of FLT3-CAR-γδT Cells in Acute Myeloid Leukemia. [PDF]

Cancers (Basel)
Wang X, You F, Gu Y, Ma X, Jiang L, Wu H, An G, Tian X, Yang L.   +8 more
europepmc   +1 more source

Serum sCD25 predicts mortality and reflects IL-2-driven dysregulation of CD4⁺CD25⁺ T cells in severe fever with thrombocytopenia syndrome. [PDF]

Trop Med Health
Zhang Y, Song H, Wang J, Su K, Zhu G, Jia B, Hu L, Xue J, Su X, Li J, Xia Q, Wu W.   +11 more
europepmc   +1 more source