Results 251 to 260 of about 2,060,350 (286)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Non-α-biased IL-2 enhances both intratumoral and subcutaneous CpG/α-OX40 therapy, unleashing systemic antitumor immunity in mice. [PDF]

J Immunother Cancer
Huang K, Ding X, Wen X, Huang C, Chen Y, Zhou X, Zhou L, He Y, Bai Z, Zhang C, Jin Y, Li J, Fei Z, Li W, Chen C.   +14 more
europepmc   +1 more source

A glimpse into the application of the immunomodulatory effect of IL-2 in systemic lupus erythematosus. [PDF]

Front Med (Lausanne)
Xia X, Qu R.
europepmc   +1 more source

Oncolytic VSV-IL-2 has enhanced anticancer vaccination adjuvant abilities. [PDF]

J Immunother Cancer
Mullins-Dansereau V, Myre ML, Bardoul A, Geoffroy K, Rallo Pita MJ, Béland D, Desaulniers KL, Roy DG, Bourgeois-Daigneault MC.   +8 more
europepmc   +1 more source

A novel case of acute localized and generalized exanthematous pustulosis following IL-2 analogue injection amplified by immune checkpoint inhibition. [PDF]

JAAD Case Rep
Johnsen NA, Carlisle R, Baghoomian W, Pierce JL, Nguyen MO.   +4 more
europepmc   +1 more source

The Multifaceted Role of the IL-2 Cytokine Family in Melanoma: Mechanisms, Therapeutic Implications, and Immune Modulation. [PDF]

J Immunol Res
Daghaighei M, Dodge S, Bolandi S, Youssef B, Attarde N, Maddahi M, Mostofi M, Morovatshoar R, Mostafavi M, Majid D, Joulani M, Tamimi P, Sharafi M, Behfar Q, Boushehri YG, Azani A.   +15 more
europepmc   +1 more source

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The IL-2/IL-2 receptor system: A current overview

Cell, 1993
Tadatsugu Taniguchi and Yasuhiro Mlnami Institute for Molecular and Cellular Biology Osaka University Yamadaoka 1-3, Suita-shi Osaka 565 Japan The discovery and molecular characterization of interleu- kin-2 (IL-2) has had a considerable impact on basic and clinical immunology(Morgan et al., 1976; Taniguchi et al., 1963; Rosenberg et al., 1965).
T, Taniguchi, Y, Minami
openaire   +2 more sources

17-β-ESTRADIOL SUPPRESSES IL-2 AND IL-2 RECEPTOR

Cytokine, 2001
Interleukin-2 (IL-2) plays an important role in adaptive immune responses. These responses differ between females and males and may be due to the sex steroid estrogen. In this investigation we show that estrogen suppresses IL-2 production from activated peripheral blood T cells and CD4+ T cell lines at the transcriptional level.
R W, McMurray, K, Ndebele, K J, Hardy, J K, Jenkins   +3 more
openaire   +2 more sources

Chimera of IL-2 Linked to Light Chain of anti-IL-2 mAb Mimics IL-2/anti-IL-2 mAb Complexes Both Structurally and Functionally

ACS Chemical Biology, 2013
IL-2/anti-IL-2 mAb immunocomplexes were described to have dramatically higher activity than free IL-2 in vivo. We designed protein chimera consisting of IL-2 linked to light chain of anti-IL-2 mAb S4B6 through flexible oligopeptide spacer (Gly(4)Ser)(3).
Jakub, Tomala, Jirina, Kovarova, Martina, Kabesova, Petra, Votavova, Helena, Chmelova, Barbora, Dvorakova, Blanka, Rihova, Marek, Kovar   +7 more
openaire   +2 more sources