Results 211 to 220 of about 8,411,708 (236)

Commentary: Guselkumab binding to CD64⁺ IL-23-producing myeloid cells enhances potency for neutralizing IL-23 signaling. [PDF]

Front Immunol
Valdiserra G, Di Salvo C, Fornai M, Antonioli L.   +3 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Exploring the functional food potential of Clitoria ternatea in modulating TNF-α/IL-23/IL-17 axis-related inflammatory pathways relevant to psoriasis. [PDF]

Sci Rep
Mustika A, Purba AKR, Khaerunnisa S, Azzahra ZM, Herisulistyo A, Mayangsari E, Awaludin R, Balan SS, Yang U, Park MN, Ko SG, Nurkolis F, Kim B.   +12 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Tra il "facchino" e il "filosofo" : "il terzo istruito"

, 2016
BINANTI, Luigino, Istruito, Tra il “facchino” e. il “filosofo”: il “Terzo   +1 more
core  

Intraclonal Enrichment of IL-23 Receptor Complex Expression in the Proliferative Fraction of Chronic Lymphocytic Leukemia. [PDF]

Int J Mol Sci
Cardillo M, Ferrero F, Bertola N, Nano E, Massara R, Capra MC, Reverberi D, Colombo M, Cossu V, Ghiotto F, Ibatici A, Angelucci E, Neri A, Gentile M, Morabito F, Mazzarello AN, Ferrarini M, Fais F, Cutrona G.   +18 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Short-term efficacy of biologics targeting the IL-17/IL-23 axis in scalp, nail, and palmoplantar psoriasis: a network meta-analysis of randomized controlled trials. [PDF]

Front Immunol
Zhang S, Lam T, Du Y, Chen X, Zhang H, Li L, Zhang G.   +6 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source