IL-23 Inhibitors in Psoriasis: What Have We Learnt so Far? [PDF]
J Inflamm ResMegna M +5 more
europepmc +1 more source
Anti-IL-17 and Anti-IL-23 Therapies Modulate Serum Biomarkers of Intestinal Dysbiosis and Oxidative Stress Linked to Cardiovascular Risk in Patients with Psoriasis [PDF]
Giuseppe Annunziata +17 more
openalex +1 more source
Cutting Edge: IFN- Is a Negative Regulator of IL-23 in Murine Macrophages and Experimental Colitis
, 2020 Katsuyoshi Matsuoka +5 more
openalex +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
The IL-23/IL-17 axis in Behçet's syndrome pathogenesis: from immunological perspectives to therapeutic implications. [PDF]
Front ImmunolNaffaa ME +4 more
europepmc +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
High-Dose, Extended Half-Life IL-23 Inhibitors: the Next Big Step in Psoriasis Care? [PDF]
Dermatol Ther (Heidelb)Torres T, Blauvelt A.
europepmc +1 more source
Counterregulation between thymic stromal lymphopoietin– and IL-23–driven immune axes shapes skin inflammation in mice with epidermal barrier defects [PDF]
, 2016 Jiagui Li +8 more
openalex +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Linkage between IL-23 and coronary arterial lesions in pediatric patients with Kawasaki disease. [PDF]
Front PediatrWei Y, Feng S, Wu J, Yang P, Su Y, Yi Q.
europepmc +1 more source