Results 301 to 310 of about 1,375,213 (331)

Genetic Variants of the IL-23/IL-17 Axis and Its Association With Periodontal Disease: A Systematic Review. [PDF]

Immun Inflamm Dis
Rodríguez-Montaño R, Alarcón-Sánchez MA, Lomelí-Martínez SM, Martínez-Bugarin CH, Heboyan A.   +4 more
europepmc   +1 more source

Correction: HPV16 E6 and E7 expressing cancer cells suppress the antitumor immune response by upregulating KLF2-mediated IL-23 expression in macrophages. [PDF]

J Immunother Cancer
europepmc   +1 more source

Safety and Efficacy of Anti-IL-23 Monoclonal Antibody QX004N for Patients With Psoriasis: A Randomized Clinical Trial.

JAMA Dermatol
Li X, Li B, Yang D, Wang M, Li Q, Wang N, Fang M, Liu J, Zhang H, Wu M, Li C, Zhu X, Ding Y, Li S.   +13 more
europepmc   +1 more source

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Biologics update: IL‐23 inhibitors

Dermatological Reviews, 2021
AbstractIntroductionIL‐23 inhibitors have shown long‐term efficacy and safety for the treatment of moderate‐to‐severe plaque psoriasis in adults. Guselkumab has also been approved to treat psoriatic arthritis while tildrakizumab and risankizumab are currently under investigation for treating psoriatic arthritis.
Julie Hong, Edward Hadeler, Megan Mosca, Mimi Chung, Samuel Yeroushalmi, Marwa Hakimi, Wilson Liao, Tina Bhutani   +7 more
openaire   +1 more source

IL-23 and the Tumor Microenvironment

2021
The tumor microenvironment (TME), which assists in the development, progression, and metastasis of malignant cells, is instrumental in virtually every step of tumor development. While a healthy TME can protect against malignancy, in an unhealthy state, it can result in aberrant cellular behavior and augment tumor progression.
Sweta, Subhadarshani, Nabiha, Yusuf, Craig A, Elmets   +2 more
openaire   +2 more sources

Targeting IL-23 in Crohn’s disease

Expert Review of Clinical Immunology, 2018
Interleukin (IL)-23, a cytokine produced by antigen presenting cells, targets both T cells and non-T cell types with the downstream effect of enhancing inflammatory pathways. Genome-wide association studies and data from human and mouse models of intestinal inflammation support the pathogenic role of IL-23 in Crohn's disease (CD), an immune-mediated ...
Silvia, Sedda, Gerolamo, Bevivino, Giovanni, Monteleone   +2 more
openaire   +2 more sources

Targeting IL-23 in human diseases

Expert Opinion on Therapeutic Targets, 2010
IL-23 is one of the most intriguing cytokine for its many immunological functions, which are the basis of its important role in host defense but also of its possible contribution to the pathogenesis of several diseases.The literature and patents about IL-23 pathway and their targeting in therapeutic potential applications. Findings published within the
D'ELIOS, MARIO MILCO, DEL PRETE, GIANFRANCO, AMEDEI, AMEDEO   +2 more
openaire   +4 more sources

Employing an IL-23 p19 Vaccine to Block IL-23 Ameliorates Chronic Murine Colitis

Immunotherapy, 2013
Overexpression of IL-23 has been implicated in the pathogenesis of Crohn's disease. Using vaccines to block overexpressed endogenous cytokines has emerged as a new therapeutic strategy for the long-term treatment of the disease.We sought to develop peptide-based vaccines specific to IL-23 and evaluate their effects in colitis mice.The vaccine was ...
Qingdong, Guan, Helen A, Burtnick, Gefei, Qing, Carolyn R, Weiss, Allan G, Ma, Yanbing, Ma, Richard J, Warrington, Zhikang, Peng   +7 more
openaire   +2 more sources

IL-23 Inhibitors for Psoriasis

Current Dermatology Reports, 2018
The purpose of this article is to review current understanding of the role of IL-23 in psoriasis and the available results to date on clinical trials establishing the efficacy and safety of IL-23 inhibitors for use in adults with moderate-to-severe plaque psoriasis.
Kristen M. Beck, Eric J. Yang, Sahil Sekhon, Tina Bhutani   +3 more
openaire   +1 more source

Serum IL-23 in asthmatic children.

Journal of biological regulators and homeostatic agents, 2012
Asthma is characterized by airway inflammation that is controlled by a complex cytokine network. The Th1/Th2 imbalance has been well documented in the pathogenesis of allergic asthma. Recently, Th17 cells and regulatory T (Treg) cells have been found to participate in the pathogenesis of allergic asthma.
Ciprandi, G, CUPPARI, caterina, SALPIETRO DAMIANO, ANNA MARIA, Tosca, M, Grasso, Loredana, RIGOLI, Luciana Concetta, La Rosa, M, Marseglia, G. L, Miraglia Del Giudice, M, SALPIETRO DAMIANO, Carmelo   +9 more
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