Results 61 to 70 of about 1,179,733 (270)
Rapid Response to Trametinib Combined With Chemotherapy for Infant BRAF‐Fused Chiasmatic Glioma
Pediatric Blood &Cancer, EarlyView.ABSTRACT Infants, less than 1 year, with chiasmatic gliomas (ICG) present a major therapeutic challenge due to large tumor size, decreased vision, rapid progression, and poor response to vincristine/carboplatin chemotherapy. The majority have a BRAF fusion, which may respond to downstream MEK inhibitors but response time is slow. There are no safety or
Helen Toledano +7 more
wiley +1 more source
Escape from immunotherapy: possible mechanisms that influence tumor regression/progression [PDF]
, 2004 Tumor escape is one major obstacle that has to be addressed prior to designing and delivering successful immunotherapy. There is compelling evidence to support the notion that immunogenic tumors, in murine models and cancer patients, can be rejected by ...
Ahmad, M, Ali, SA, Rees, RC
core +1 more source
Immune regulation in pathophysiology and targeted therapy for itch in atopic dermatitis
Dermatologica Sinica, 2016 Itch is an unpleasant perception that provokes one to desire to scratch. It results from the activation of free nerve endings by noxious stimuli in the skin.
Chih-Hung Lee
doaj +1 more source
Basophils in pruritic skin diseases
Frontiers in Immunology, 2023 Basophils are rare cells in the peripheral blood which have the capability to infiltrate into the skin. Invasion of basophils has been detected in pruritic skin diseases, including atopic dermatitis, bullous pemphigoid, chronic spontaneous urticaria and ...
Daniela Wiebe +6 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Purpose Cognitive and psychological difficulties could negatively interfere with treatment adherence and quality of life before and after hematopoietic stem cell transplant (HSCT). Methods to mitigate these changes may have positive effects on treatment success.
Kristen L. Votruba +11 more
wiley +1 more source
The WHO World Health Report 2001 on mental health [PDF]
, 2017 Scopo - La OMS stima che 450 milioni di persone soffrano di disturbi psichiatrici o neurologici e che fra il 10 e il 20% della popolazione infantile presenti qualche disturbo mentale o comportamentale. I disturbi mentali e neurologici rappresentano il 31%
Saraceno, Benedetto
core
Pediatric Blood &Cancer, EarlyView.ABSTRACT A second allogeneic (allo‐)hematopoietic stem cell transplantation (HSCT2) is a potential curative option for pediatric patients with acute lymphoblastic leukemia (ALL) following relapse after first allogeneic transplantation (HSCT1), but its efficacy is limited by high relapse rates and transplant‐related toxicity in highly pretreated ...
Ava Momm +10 more
wiley +1 more source
Regulation of Reactive Oxygen Species and the Antioxidant Protein DJ-1 in Mastocytosis [PDF]
, 2016 Neoplastic accumulation of mast cells in systemic mastocytosis (SM) associates with activating mutations in the receptor tyrosine kinase KIT. Constitutive activation of tyrosine kinase oncogenes has been linked to imbalances in oxidant/antioxidant ...
Bai, Yun +10 more
core +5 more sources
The release of IL-31 and IL-13 after nasal allergen challenge and their relation to nasal symptoms
Clinical and Translational Allergy, 2012 Background IL-31, a recently discovered member of the gp130/IL-6 cytokine family, is mainly expressed by human mast cells and T helper type 2 cells. IL-31 is a key trigger of atopic dermatitis.
Baumann Ralf +7 more
doaj +1 more source
IL-31 a TH2 Cytokine Involved in Immunity and Inflammation
International Journal of Immunopathology and Pharmacology, 2010 Cytokines are immunal regulatory proteins, however they also play a relevant role in inflammatory diseases. IL-31 is a newly discovered cytokine expressed primarily in TH2 cells, introduced by activated CD4+ T cells. IL-31 is capable of inducing chemokines and other cytokines in several inflammatory diseases via its surface receptor.
CASTELLANI, Maria Luisa +14 more
openaire +6 more sources