Results 41 to 50 of about 8,409,985 (265)

Human basophils are a source of ‐ and are differentially activated by ‐ IL‐31 [PDF]

Clinical & Experimental Allergy, 2017
SummaryBackgroundBasophils are important effector cells involved in the pathogenesis of inflammatory skin diseases including chronic urticaria which is associated by increased IL‐31 serum levels. So far the effects of IL‐31 on human basophils are unknown.ObjectiveTo analyse the functional role of IL‐31 in basophil biology.MethodsIL‐31 expression was ...
U, Raap, M, Gehring, S, Kleiner, U, Rüdrich, B, Eiz-Vesper, H, Haas, A, Kapp, B F, Gibbs   +7 more
openaire   +2 more sources

Interleukin-31: A Pro-inflammatory Oriented Cytokine

Frontiers in Bioscience-Landmark
Type 2 immunity is represented by T helper 2 (Th2) lymphocytes and the cytokines produced downstream (Interleukin (IL)-4, IL-13, IL-31). They are increasingly recognized as pivotal mediators in the pathogenesis of immune-mediated dermatological ...
Giuseppe Murdaca, Francesca Paladin, Andrea Orsi, Sebastiano Gangemi   +3 more
doaj   +1 more source

Pro-inflammatory signaling by IL-10 and IL-22: bad habit stirred up by interferons? [PDF]

, 2013
Interleukin (IL)-10 and IL-22 are key members of the IL-10 cytokine family that share characteristic properties such as defined structural features, usage of IL-10R2 as one receptor chain, and activation of signal transducer and activator of ...
Heiko Mühl, Heiko eMühl, Mühl, Heiko
core   +1 more source

Use of Cytopoint in the Allergic Dog

Frontiers in Veterinary Science, 2022
Allergic dermatitis is the most common type of skin disease in dogs. Of all dogs, 20 to 30% present with some type of allergic dermatitis. Pruritus is one of the most important signs of allergic dermatitis and is often the most challenging to control ...
Margaret Gober, Andrew Hillier, Manuel A. Vasquez-Hidalgo, Manuel A. Vasquez-Hidalgo, Deborah Amodie, Martha A. Mellencamp   +5 more
doaj   +1 more source

IL-31 increases epidermal cell proliferation in skin.

, 2016
C57BL/6 mice were injected intradermally with saline or rIL-31 (20μg) daily for 14 days. A portion of dorsal skin was excised and processed for thin-sectioning and immunohistochemistry.
Satish K. Madala (515068), Brijendra Singh (3074262), Gurjit H. Khurana (3074253), Stacey R. Dillon (3074259), Anil G. Jegga (59413), Kumar S. Shanmukhappa (3074256), Mario Medvedovic (1779), Ramakrishna Edukulla (515069)   +7 more
core   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

IL-31 a TH2 Cytokine Involved in Immunity and Inflammation

International Journal of Immunopathology and Pharmacology, 2010
Cytokines are immunal regulatory proteins, however they also play a relevant role in inflammatory diseases. IL-31 is a newly discovered cytokine expressed primarily in TH2 cells, introduced by activated CD4 + T cells.
CASTELLANI, Maria Luisa, FELACO, PAOLO, Galzio R. J., TRIPODI, Domenico, TONIATO, ELENA, De Lutiis M. A., FULCHERI, Mario, Caraffa A., Antinolfi P., Tetè S., FELACO, Mario, CONTI, FIORELLA, Pandolfi F., Theoharides T. C., Shaik Dasthagirisaheb Y. B.   +14 more
openaire   +6 more sources

Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan, Michael Abele, Calogero Virgone, Michaela Kuhlen, Ricardo Lopez‐Almarez, Tal Ben‐Ami, Ewa Bien, Maja Cesen, Malgorzata A. Krawczyk, Andrea Ferrari, Gianni Bisogno, Yves Reguerre, Dominik T. Schneider, Louise Galmiche, Jorg Fuchs, Sarah Braungart, Bilgehan Yalcin, Ines B. Brecht, Daniel Orbach   +18 more
wiley   +1 more source

IL-31 regulates expression of genes involved in skin damage.

, 2016
(A) C57BL/6 mice were injected intradermally with saline or rIL-31 (20μg) daily for 14 days. A portion of dorsal skin was excised and RNA was isolated. RNA-Seq analysis was performed using next-generation sequencing.
Satish K. Madala (515068), Brijendra Singh (3074262), Gurjit H. Khurana (3074253), Stacey R. Dillon (3074259), Anil G. Jegga (59413), Kumar S. Shanmukhappa (3074256), Mario Medvedovic (1779), Ramakrishna Edukulla (515069)   +7 more
core   +1 more source

Eosinophils are a Major Source of Interleukin-31 in Bullous Pemphigoid

Acta Dermato-Venereologica, 2018
Bullous pemphigoid (BP) is characterized by substantial skin and blood eosinophilia as well as intensive pruritus. Since the pruritogenic cytokine interleukin (IL)-31 is increased in inflammatory skin diseases the aim of this study was to determine ...
Urda Rüdrich, Manuela Gehring, Eleni Papakonstantinou, Anja Illerhaus, Judith Engmann, Alexander Kapp, Karin Hartmann, N. Helge Meyer, Bernhard F. Gibbs, Ulrike Raap   +9 more
doaj   +1 more source