Results 41 to 50 of about 1,187,146 (230)

[Translated article] Nemolizumab: An Innovative Biologic Treatment to Control Interleukin 31, a Key Mediator in Atopic Dermatitis and Prurigo Nodularis

Actas Dermo-Sifiliográficas, 2022
Interleukin 31 (IL-31) is a neurocytokine that stimulates sensory neurons involved in pruritus. It contributes to skin barrier inflammation, dysfunction, and remodeling.
E. Serra-Baldrich, L.F. Santamaria-Babí, J. Francisco Silvestre   +2 more
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Signaling by IL-31 and functional consequences

European Journal of Cell Biology, 2012
Cytokines are key to control cellular communication. Interleukin-31 (IL-31) was recently discovered as a new member of the IL-6 family of cytokines. IL-31 signals through a heterodimeric receptor composed of OSMR and IL-31RA, a complex that stimulates the JAK-STAT, the RAS/ERK and the PI3K/AKT signal transduction pathways.
Christian, Cornelissen, Juliane, Lüscher-Firzlaff, Jens Malte, Baron, Bernhard, Lüscher   +3 more
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IL-31: A new key player in dermatology and beyond [PDF]

Journal of Allergy and Clinical Immunology, 2018
IL-31 is a novel cytokine expressed in many human tissues and involved mainly in TH2-weighted inflammation. IL-31 signals through a receptor complex consisting of IL-31 receptor α and oncostatin M receptor β. The available data show that IL-31 is strongly linked with chronic pruritic skin disorders, such as atopic eczema, and represents a novel target ...
Işın Sinem, Bağci, Thomas, Ruzicka
openaire   +2 more sources

New insight of itch mediators and proinflammatory cytokines in epidermolysis bullosa

Journal of Cutaneous Immunology and Allergy, 2022
Objectives Epidermolysis bullosa (EB) is a hereditary disorder characterized by mechanical stress‐induced blistering. The presence of extracutaneous complications such as cardiomyopathy and renal disease observed in severe EB subtypes and the fact that ...
Hong Ha Nguyen, Satoru Shinkuma, Ryota Hayashi, Tatsuya Katsumi, Tomoki Nishiguchi, Ken Natsuga, Yasuyuki Fujita, Riichiro Abe   +7 more
doaj   +1 more source

Nemolizumab: un innovador tratamiento biológico para el control de la interleuquina 31 (IL-31) clave en la dermatitis atópica y el prurigo nodular

Actas Dermo-Sifiliográficas, 2022
Resumen: La citoquina IL-31 es una neurocitoquina que estimula las neuronas sensoriales relacionadas con el picor, contribuye a la inflamación, la disfunción y remodelación de la barrera epidérmica. Al interrelacionar los sistemas inmunológico y nervioso
E. Serra-Baldrich, L.F. Santamaría-Babí, J. Francisco Silvestre   +2 more
doaj   +1 more source

Human basophils are a source of ‐ and are differentially activated by ‐ IL‐31 [PDF]

Clinical & Experimental Allergy, 2017
SummaryBackgroundBasophils are important effector cells involved in the pathogenesis of inflammatory skin diseases including chronic urticaria which is associated by increased IL‐31 serum levels. So far the effects of IL‐31 on human basophils are unknown.ObjectiveTo analyse the functional role of IL‐31 in basophil biology.MethodsIL‐31 expression was ...
U, Raap, M, Gehring, S, Kleiner, U, Rüdrich, B, Eiz-Vesper, H, Haas, A, Kapp, B F, Gibbs   +7 more
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The Protective Effects of IL-31RA Deficiency During Bleomycin-Induced Pulmonary Fibrosis

Frontiers in Immunology, 2021
Idiopathic Pulmonary Fibrosis (IPF) is a severe fibrotic lung disease characterized by excessive collagen deposition and progressive decline in lung function.
Dan J. K. Yombo, Dan J. K. Yombo, Varshini Odayar, Varshini Odayar, Nishant Gupta, Anil G. Jegga, Anil G. Jegga, Satish K. Madala, Satish K. Madala   +8 more
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Increased levels of interleukin 31 (IL-31) in osteoporosis [PDF]

BMC Immunology, 2015
Several inflammatory cytokines play a key part in the induction of osteoporosis. Until now, involvement of the Th2 cytokine interleukin-31 (IL-31) in osteoporosis hadn't yet been studied. IL-31 is a proinflammatory cytokine mediating multiple immune functions, whose involvement in a wide range of diseases, such as atopic dermatitis, inflammatory bowel ...
GINALDI, Lia, DE MARTINIS, MASSIMO MARIA MARCELLO, Ciccarelli F, Saitta S, Imbesi S, Mannucci C, Gangemi S.   +6 more
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Interrelationship and Sequencing of Interleukins4, 13, 31, and 33 – An Integrated Systematic Review: Dermatological and Multidisciplinary Perspectives

Journal of Inflammation Research, 2022
Alin Laurentiu Tatu,1– 3,* Thomas Nadasdy,3,4 Anca Arbune,5,* Valentin Chioncel,6,* Carmen Bobeica,7 Elena Niculet,3,* Alina Viorica Iancu,7 Caterina Dumitru,8 Valentin Tudor Popa,3,9 Nicolas Kluger,10,11 Victor Gabriel Clatici,11 Claudiu
Tatu AL, Nadasdy T, Arbune A, Chioncel V, Bobeica C, Niculet E, Iancu AV, Dumitru C, Popa VT, Kluger N, Clatici VG, Vasile CI, Onisor C, Nechifor A   +13 more
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Determination of interleukin 31 (IL-31) serum levels in allergic rhinitis patients

International Journal of Pediatrics & Adolescent Medicine, 2014
Background and objectives: IL-31 appears to be an important regulator of Th2 re-sponses and was found to be present in patients with atopic dermatitis. This study was con-ducted to compare IL-31 serum levels in allergic rhinitis (AR) patients and normal ...
Noor Suryani Mohd Ashari, Siti Noor Syuhada Mohd Amin, Wan Zuraida Wan Abdul Hamid, Mustaffa Musa, Azriani Abdul Rahman, Irfan Mohamad   +5 more
doaj   +1 more source