Results 21 to 30 of about 60,064,270 (228)

Dupilumab for cancer-associated refractory pruritus

Journal of Allergy and Clinical Immunology: Global, 2023
Background: Pruritus can be an intolerable symptom in patients with cancer. Type 2 inflammation, and specifically, the cytokines IL-4, IL-13, and IL-31, play major roles in the itching process.
Aviv Talmon, MD, Shlomo Elias, MD, PhD, Limor Rubin, MD, Yaarit Ribak, MD, Eyal Ben Dori, MD, Oded Shamriz, MD, Michal Lotem, MD, Irit Adini, PhD, Yuval Tal, MD, PhD   +8 more
doaj   +1 more source

Interleukin-31 in serum and cerebrospinal fluid of dogs with syringomyelia

BMC Veterinary Research, 2023
Background Syringomyelia is a spinal cord cavity containing cerebrospinal fluid (CSF)-like fluid. If syringomyelia asymmetrically involves the dorsal horn grey matter of the spinal cord, affected dogs show increased signs of dysesthesia and neuropathic ...
Laura Lemke, Regina Carlson, Thomas Flegel, Andrea Volk, Holger Andreas Volk, Andrea Tipold, Jasmin Nicole Nessler   +6 more
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Immune response in atopic dermatitis: main pathogenetic mechanisms and stage-dependent correlations with age in regard to dermatological and non-dermatological systemic processes

Медицинская иммунология, 2021
Atopic dermatitis is one of the most common chronic inflammatory skin diseases caused by both terminal defects in keratinocyte differentiation, and pronounced type 2 immune responses.
M. B. Drozhdina, E. V. Suslova
doaj   +1 more source

Microbiota and IL-33/31 Axis Linkage: Implications and Therapeutic Perspectives in Atopic Dermatitis and Psoriasis

Biomolecules, 2023
Microbiome dysbiosis and cytokine alternations are key features of atopic dermatitis (AD) and psoriasis (PsO), two of the most prevalent and burdensome pruritic skin conditions worldwide.
Laura Bonzano, Francesco Borgia, Rossella Casella, Andrea Miniello, Eustachio Nettis, Sebastiano Gangemi   +5 more
doaj   +1 more source

IL-31-Driven Skin Remodeling Involves Epidermal Cell Proliferation and Thickening That Lead to Impaired Skin-Barrier Function. [PDF]

, 2016
Interleukin-31 (IL-31) is a type 2 helper T-cell-derived cytokine that has recently been shown to cause severe inflammation and tissue remodeling in multiple chronic diseases of the skin and lungs.
Gurjit H Khurana Hershey, Kumar S Shanmukhappa, Satish K. Madala (515068), Anil G Jegga, Gurjit H. Khurana (3074253), Kumar S. Shanmukhappa (3074256), Mario Medvedovic (1779), Ramakrishna Edukulla, Satish K Madala, Brijendra Singh (3074262), Brijendra Singh, Stacey R. Dillon (3074259), Anil G. Jegga (59413), Ramakrishna Edukulla (515069), Mario Medvedovic, Stacey R Dillon   +15 more
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[Translated article] Nemolizumab: An Innovative Biologic Treatment to Control Interleukin 31, a Key Mediator in Atopic Dermatitis and Prurigo Nodularis

Actas Dermo-Sifiliográficas, 2022
Interleukin 31 (IL-31) is a neurocytokine that stimulates sensory neurons involved in pruritus. It contributes to skin barrier inflammation, dysfunction, and remodeling.
E. Serra-Baldrich, L.F. Santamaria-Babí, J. Francisco Silvestre   +2 more
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New insight of itch mediators and proinflammatory cytokines in epidermolysis bullosa

Journal of Cutaneous Immunology and Allergy, 2022
Objectives Epidermolysis bullosa (EB) is a hereditary disorder characterized by mechanical stress‐induced blistering. The presence of extracutaneous complications such as cardiomyopathy and renal disease observed in severe EB subtypes and the fact that ...
Hong Ha Nguyen, Satoru Shinkuma, Ryota Hayashi, Tatsuya Katsumi, Tomoki Nishiguchi, Ken Natsuga, Yasuyuki Fujita, Riichiro Abe   +7 more
doaj   +1 more source

Pro-inflammatory signaling by IL-10 and IL-22: bad habit stirred up by interferons? [PDF]

, 2013
Interleukin (IL)-10 and IL-22 are key members of the IL-10 cytokine family that share characteristic properties such as defined structural features, usage of IL-10R2 as one receptor chain, and activation of signal transducer and activator of ...
Heiko Mühl, Heiko eMühl, Mühl, Heiko
core   +1 more source

Nemolizumab: un innovador tratamiento biológico para el control de la interleuquina 31 (IL-31) clave en la dermatitis atópica y el prurigo nodular

Actas Dermo-Sifiliográficas, 2022
Resumen: La citoquina IL-31 es una neurocitoquina que estimula las neuronas sensoriales relacionadas con el picor, contribuye a la inflamación, la disfunción y remodelación de la barrera epidérmica. Al interrelacionar los sistemas inmunológico y nervioso
E. Serra-Baldrich, L.F. Santamaría-Babí, J. Francisco Silvestre   +2 more
doaj   +1 more source

Interrelationship and Sequencing of Interleukins4, 13, 31, and 33 – An Integrated Systematic Review: Dermatological and Multidisciplinary Perspectives

Journal of Inflammation Research, 2022
Alin Laurentiu Tatu,1– 3,* Thomas Nadasdy,3,4 Anca Arbune,5,* Valentin Chioncel,6,* Carmen Bobeica,7 Elena Niculet,3,* Alina Viorica Iancu,7 Caterina Dumitru,8 Valentin Tudor Popa,3,9 Nicolas Kluger,10,11 Victor Gabriel Clatici,11 Claudiu
Tatu AL, Nadasdy T, Arbune A, Chioncel V, Bobeica C, Niculet E, Iancu AV, Dumitru C, Popa VT, Kluger N, Clatici VG, Vasile CI, Onisor C, Nechifor A   +13 more
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