Results 11 to 20 of about 1,187,146 (230)
IL-31 induces antitumor immunity in breast carcinoma. [PDF]
J Immunother Cancer, 2020 Background Immunomodulatory agents that induce antitumor immunity have great potential for treatment of cancer. We have previously shown that interleukin (IL)-31, a proinflammatory cytokine from the IL-6 family, acts as an antiangiogenic agent.
Kan T +6 more
europepmc +5 more sources
Blockage of the IL-31 Pathway as a Potential Target Therapy for Atopic Dermatitis. [PDF]
Pharmaceutics, 2023 Atopic dermatitis (AD), a pruritic, inflammatory chronic disease with multifactorial pathogenesis, has been a therapeutic challenge. Novel target treatments aim to reduce not only the immunologic dysfunction and microbiome dysbiosis but also the recovery
Orfali RL, Aoki V.
europepmc +2 more sources
IL-31, itch and hematological malignancies. [PDF]
Clin Mol Allergy, 2021 AbstractPruritus is one of the most common symptoms experienced by neoplastic patients. The pathogenesis of neoplastic itch is complex and multifactorial and could be due to an unbalanced production of humoral mediators by altered immune effector cells. IL-31 is a pro-inflammatory cytokine produced by CD4 + T helper cells. The aim of this review was to
Di Salvo E +3 more
europepmc +5 more sources
The molecular basis for IL-31 production and IL-31-mediated itch transmission: from biology to drug development. [PDF]
Int Immunol, 2021 Abstract Atopic dermatitis (AD) is one of the most prevalent chronic inflammatory skin diseases in the world. It is characterized by recurrent eczematous lesions and intense itch, and many cytokines are involved in the pathogenesis of AD. Among them, much attention has been paid to interleukin 31 (IL-31) as an AD-associated itch mediator.
Kunimura K, Fukui Y.
europepmc +4 more sources
Significance of interleukin-31 (IL-31) gene polymorphisms and IL-31 serum level in psoriasis in correlation with pruritus. [PDF]
Postepy Dermatol Alergol, 2021 Interleukin-31 (IL-31) impact on the development and clinical presentation of psoriasis as well as pruritus has not been widely investigated so far.To analyse IL-31 -1066G/A and -2057G/A promoter gene polymorphisms as well as serum IL-31 level and their correlation with severity of psoriasis and pruritus in the population of northern Poland.The study ...
Purzycka-Bohdan D +7 more
europepmc +4 more sources
IL-31/33 Axis in Atopic Dermatitis. [PDF]
Int J Mol SciAtopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by impaired epidermal barrier function, immune dysregulation (e.g., Th2 polarization), genetic factors (e.g., filaggrin mutations), environmental triggers and microbial dysbiosis, leading to pruritus and eczematous lesions.
Łacwik J +5 more
europepmc +5 more sources
IL-31: State of the Art for an Inflammation-Oriented Interleukin. [PDF]
Int J Mol Sci, 2022 Interleukin 31 belongs to the IL-6 superfamily, and it is an itch mediator already studied in several diseases, comprising atopic dermatitis, allergic pathologies, and onco-hematological conditions. This research aims to assess the role of this cytokine in the pathogenesis of these conditions and its potential therapeutic role.
Borgia F +5 more
europepmc +3 more sources
The role of IL-31 and IL-34 in the diagnosis and treatment of chronic periodontitis. [PDF]
Open Life Sci, 2023 This study was devoted to demonstrating the role of IL-31 and IL-34 in the diagnosis and treatment of chronic periodontitis (CP). From the results, we found that the IL-31 and IL-34 levels were significantly increased in GCF and serum of CP patients ...
Luo Y, Ding Y, Chen Y.
europepmc +2 more sources
The Novel Role of MIF in the Secretion of IL-25, IL-31, and IL-33 from PBMC of Patients with Rheumatoid Arthritis. [PDF]
Molecules, 2021 Rheumatoid arthritis (RA) is an autoimmune inflammatory joint disease with complex pathogenesis associated with cytokine dysregulation. Macrophage migration inhibitory factor (MIF) plays a role in systemic inflammation and joint destruction in RA and ...
García-Arellano S +5 more
europepmc +2 more sources
Anti-atopic dermatitis effect of fraxinellone via inhibiting IL-31 in vivo and in vitro. [PDF]
HeliyonChronic recurrent itch and skin inflammation are prominent features of atopic dermatitis (AD), which is closely related to the immune response driven by T-helper type 2 (Th2) cells.
Yang N +6 more
europepmc +2 more sources