Results 31 to 40 of about 8,409,985 (265)

IL-31-Driven Skin Remodeling Involves Epidermal Cell Proliferation and Thickening That Lead to Impaired Skin-Barrier Function. [PDF]

, 2016
Interleukin-31 (IL-31) is a type 2 helper T-cell-derived cytokine that has recently been shown to cause severe inflammation and tissue remodeling in multiple chronic diseases of the skin and lungs.
Gurjit H Khurana Hershey, Kumar S Shanmukhappa, Satish K. Madala (515068), Anil G Jegga, Gurjit H. Khurana (3074253), Kumar S. Shanmukhappa (3074256), Mario Medvedovic (1779), Ramakrishna Edukulla, Satish K Madala, Brijendra Singh (3074262), Brijendra Singh, Stacey R. Dillon (3074259), Anil G. Jegga (59413), Ramakrishna Edukulla (515069), Mario Medvedovic, Stacey R Dillon   +15 more
core   +1 more source

IL-31 transgenic mice show reduced allergen-induced lung inflammation. [PDF]

Eur J Immunol, 2021
Interleukin‐31 (IL‐31) is a Th2 cell–derived cytokine that has been closely linked to pruritic skin inflammation. More recently, enhanced IL‐31 serum levels have also been observed in patients with allergic rhinitis and allergic asthma.
Neuper T, Neureiter D, Sarajlic M, Strandt H, Bauer R, Schwarz H, Suchanek P, Korotchenko E, Dillon SR, Hammerl P, Stoecklinger A, Weiss R, Horejs-Hoeck J.   +12 more
europepmc   +2 more sources

Signaling by IL-31 and functional consequences

European Journal of Cell Biology, 2012
Cytokines are key to control cellular communication. Interleukin-31 (IL-31) was recently discovered as a new member of the IL-6 family of cytokines. IL-31 signals through a heterodimeric receptor composed of OSMR and IL-31RA, a complex that stimulates the JAK-STAT, the RAS/ERK and the PI3K/AKT signal transduction pathways.
Christian, Cornelissen, Juliane, Lüscher-Firzlaff, Jens Malte, Baron, Bernhard, Lüscher   +3 more
openaire   +2 more sources

[Translated article] Nemolizumab: An Innovative Biologic Treatment to Control Interleukin 31, a Key Mediator in Atopic Dermatitis and Prurigo Nodularis

Actas Dermo-Sifiliográficas, 2022
Interleukin 31 (IL-31) is a neurocytokine that stimulates sensory neurons involved in pruritus. It contributes to skin barrier inflammation, dysfunction, and remodeling.
E. Serra-Baldrich, L.F. Santamaria-Babí, J. Francisco Silvestre   +2 more
doaj   +1 more source

New insight of itch mediators and proinflammatory cytokines in epidermolysis bullosa

Journal of Cutaneous Immunology and Allergy, 2022
Objectives Epidermolysis bullosa (EB) is a hereditary disorder characterized by mechanical stress‐induced blistering. The presence of extracutaneous complications such as cardiomyopathy and renal disease observed in severe EB subtypes and the fact that ...
Hong Ha Nguyen, Satoru Shinkuma, Ryota Hayashi, Tatsuya Katsumi, Tomoki Nishiguchi, Ken Natsuga, Yasuyuki Fujita, Riichiro Abe   +7 more
doaj   +1 more source

Nemolizumab: un innovador tratamiento biológico para el control de la interleuquina 31 (IL-31) clave en la dermatitis atópica y el prurigo nodular

Actas Dermo-Sifiliográficas, 2022
Resumen: La citoquina IL-31 es una neurocitoquina que estimula las neuronas sensoriales relacionadas con el picor, contribuye a la inflamación, la disfunción y remodelación de la barrera epidérmica. Al interrelacionar los sistemas inmunológico y nervioso
E. Serra-Baldrich, L.F. Santamaría-Babí, J. Francisco Silvestre   +2 more
doaj   +1 more source

Interrelationship and Sequencing of Interleukins4, 13, 31, and 33 – An Integrated Systematic Review: Dermatological and Multidisciplinary Perspectives

Journal of Inflammation Research, 2022
Alin Laurentiu Tatu,1– 3,* Thomas Nadasdy,3,4 Anca Arbune,5,* Valentin Chioncel,6,* Carmen Bobeica,7 Elena Niculet,3,* Alina Viorica Iancu,7 Caterina Dumitru,8 Valentin Tudor Popa,3,9 Nicolas Kluger,10,11 Victor Gabriel Clatici,11 Claudiu
Tatu AL, Nadasdy T, Arbune A, Chioncel V, Bobeica C, Niculet E, Iancu AV, Dumitru C, Popa VT, Kluger N, Clatici VG, Vasile CI, Onisor C, Nechifor A   +13 more
doaj  

Determination of interleukin 31 (IL-31) serum levels in allergic rhinitis patients

International Journal of Pediatrics & Adolescent Medicine, 2014
Background and objectives: IL-31 appears to be an important regulator of Th2 re-sponses and was found to be present in patients with atopic dermatitis. This study was con-ducted to compare IL-31 serum levels in allergic rhinitis (AR) patients and normal ...
Noor Suryani Mohd Ashari, Siti Noor Syuhada Mohd Amin, Wan Zuraida Wan Abdul Hamid, Mustaffa Musa, Azriani Abdul Rahman, Irfan Mohamad   +5 more
doaj   +1 more source

The Protective Effects of IL-31RA Deficiency During Bleomycin-Induced Pulmonary Fibrosis

Frontiers in Immunology, 2021
Idiopathic Pulmonary Fibrosis (IPF) is a severe fibrotic lung disease characterized by excessive collagen deposition and progressive decline in lung function.
Dan J. K. Yombo, Dan J. K. Yombo, Varshini Odayar, Varshini Odayar, Nishant Gupta, Anil G. Jegga, Anil G. Jegga, Satish K. Madala, Satish K. Madala   +8 more
doaj   +1 more source

IL-31: A new key player in dermatology and beyond [PDF]

Journal of Allergy and Clinical Immunology, 2018
IL-31 is a novel cytokine expressed in many human tissues and involved mainly in TH2-weighted inflammation. IL-31 signals through a receptor complex consisting of IL-31 receptor α and oncostatin M receptor β. The available data show that IL-31 is strongly linked with chronic pruritic skin disorders, such as atopic eczema, and represents a novel target ...
Işın Sinem, Bağci, Thomas, Ruzicka
openaire   +2 more sources