Interleukin-31 and Pruritic Skin [PDF]
Journal of Clinical Medicine, 2021 Skin inflammation often evokes pruritus, which is the major subjective symptom in many inflammatory skin diseases such as atopic dermatitis and prurigo nodularis. Pruritus or itch is a specific sensation found only in the skin. Recent studies have stressed the pivotal role played by interleukin-31 (IL-31) in the sensation of pruritus. IL-31 is produced
Masutaka Furue, Mihoko Furue
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Interleukin-31 as a Clinical Target for Pruritus Treatment [PDF]
Frontiers in Medicine, 2021 In recent years, the published literature has suggested the key involvement of the cytokine interleukin-31 (IL-31) in the symptomatology of pruritus, and both IL-31 and its receptor have become potential therapeutic targets for a range of pruritic ...
Kenji Kabashima, Hiroyuki Irie
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Interleukin-31 in serum and cerebrospinal fluid of dogs with syringomyelia [PDF]
BMC Veterinary Research, 2023 Background Syringomyelia is a spinal cord cavity containing cerebrospinal fluid (CSF)-like fluid. If syringomyelia asymmetrically involves the dorsal horn grey matter of the spinal cord, affected dogs show increased signs of dysesthesia and neuropathic ...
Laura Lemke +6 more
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Interleukin-31 and Chronic Pruritus of Unknown Origin [PDF]
Biomarker Insights, 2020 Chronic pruritus of unknown origin (CPUO) is a refractory condition. The expression of Interleukin-31 (IL-31), a major pruritogenic cytokine, in CPUO patients has not been investigated.
Kanin Salao +4 more
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Capsaicin suppresses interleukin-31-induced itching partially involved in inhibiting the expression of dorsal root ganglion interleukin-31 receptor A in male mice [PDF]
Neurobiology of Pain, 2022 To elucidate the mechanisms underlying the antipruritic effect of capsaicin, we investigated how topical application of capsaicin (0.01, 0.1 and 1.0% w/v) affects spontaneous scratching in NC/Nga mice, inerleukin-31 (IL-31) induced in BALB/c mice, and IL-
Iwao Arai +4 more
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Analyzing the Antinociceptive Effect of Interleukin-31 in Mice [PDF]
International Journal of Molecular Sciences, 2023 The theory that an itch inhibits pain has been refuted; however, previous research did not investigate this theory for an interleukin-31 (IL-31)-induced itch. Previously, we have found that morphine-induced antinociception was partially reduced in IL-31 receptor A (IL-31RA)-deficient (IL-31RAKI) mice, indicating that IL-31RA may play an important role ...
Iwao Arai +4 more
europepmc +4 more sources
Possible Association of Interleukin-31/-31RA Signalling and Basophils with Itch in Porokeratosis [PDF]
Acta Dermato-Venereologica, 2023 is missing (Short communication)
Satoshi Okuno +3 more
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Interleukin-31 Signaling Bridges the Gap Between Immune Cells, the Nervous System and Epithelial Tissues [PDF]
Frontiers in Medicine, 2021 Pruritus represents one of the most common symptoms in dermatology and general medicine. Chronic pruritus severely impairs the quality of life of affected patients.
Jana Maria Nemmer +8 more
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In chronic spontaneous urticaria, IgE and C‐reactive protein are linked to distinct microRNAs and interleukin‐31 [PDF]
Clinical and Translational Allergy, 2023 Background Chronic spontaneous urticaria (CSU) is a common and disabling disease. Assessments of IgE and C‐reactive protein (CRP) are recommended in the diagnostic work‐up, but the role and clinical relevance of these biomarkers are not well ...
Ozge Sevil Karstarli Bakay +6 more
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Increased serum interleukin-31 levels correlate with pruritus in psoriatic patients: a cross-sectional study in Vietnam [PDF]
Dermatology ReportsPsoriasis is recognized not only as a skin disease but also as a systemic disorder. Interleukin-31 (IL-31) may be associated with psoriasis and systemic inflammation.
Chuyen Thi Hong Nguyen +1 more
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