Results 11 to 20 of about 56,984,652 (272)

Interleukin-31: A Pro-inflammatory Oriented Cytokine

Frontiers in Bioscience-Landmark
Type 2 immunity is represented by T helper 2 (Th2) lymphocytes and the cytokines produced downstream (Interleukin (IL)-4, IL-13, IL-31). They are increasingly recognized as pivotal mediators in the pathogenesis of immune-mediated dermatological ...
Giuseppe Murdaca, Francesca Paladin, Andrea Orsi, Sebastiano Gangemi   +3 more
doaj   +5 more sources

Interleukin-31 and Pruritic Skin. [PDF]

J Clin Med, 2021
Skin inflammation often evokes pruritus, which is the major subjective symptom in many inflammatory skin diseases such as atopic dermatitis and prurigo nodularis. Pruritus or itch is a specific sensation found only in the skin. Recent studies have stressed the pivotal role played by interleukin-31 (IL-31) in the sensation of pruritus. IL-31 is produced
Furue M, Furue M.
europepmc   +5 more sources

Interleukin-31 in Respiratory Type 2 Inflammatory Diseases: Mechanistic Insights and Therapeutic Potential [PDF]

Journal of Inflammation Research
Shuang Yao,1,2,* Yan Zhao,1,2,* Zhimeng Li,3,4 Hongfei Lou,5,* Luo Zhang1,2,4,6,* 1Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, People’s Republic of ...
Yao S, Zhao Y, Li Z, Lou H, Zhang L
doaj   +4 more sources

Interleukin-31 promotes fibrosis and T helper 2 polarization in systemic sclerosis [PDF]

Nature Communications, 2021
Systemic sclerosis (SSc) disease involves multisystem fibrosis and autoimmunity with limited treatment options. Here the authors demonstrate that IL-31 and IL-31RA are overexpressed in dermal fibroblasts from SSc patients and show that fibrosis and ...
Ai Kuzumi, Ayumi Yoshizaki, Kazuki M. Matsuda, Hirohito Kotani, Yuta Norimatsu, Maiko Fukayama, Satoshi Ebata, Takemichi Fukasawa, Asako Yoshizaki-Ogawa, Yoshihide Asano, Kyojiro Morikawa, Yutaka Kazoe, Kazuma Mawatari, Takehiko Kitamori, Shinichi Sato   +14 more
doaj   +2 more sources

Interleukin-31 Receptor α Is Required for Basal-Like Breast Cancer Progression [PDF]

Frontiers in Oncology, 2020
Purpose: Interleukin-31 receptor α (IL31RA) usually mediates IL-31 induced inflammation and allergic diseases. However, the functional roles of IL-31/IL31RA signaling in basal-like breast cancer (BLBC) progression remain totally unclear.Methods ...
Yanling He, Xinyuan Zhang, Weijun Pan, Fang Tai, Li Liang, Jian Shi, Jian Shi   +6 more
doaj   +2 more sources

Interleukin-31: The Inflammatory Cytokine Connecting Pruritus and Cancer

Frontiers in Bioscience-Landmark
Interleukin 31 (IL-31) is a proinflammatory cytokine, mainly secreted by Type II helper T cells. It signals through a heterodimeric receptor complex composed of IL-31 receptor α and oncostatin-M receptor β chain.
Sabah Akhtar, Fareed Ahmad, Majid Alam, Abdul Wahid Ansari, Shahab Uddin, Martin Steinhoff, Joerg Buddenkotte, Aamir Ahmad, Angeliki Datsi   +8 more
doaj   +3 more sources

Interleukin-31, Interleukin-31RA, and OSMR Expression Levels in Post-burn Hypertrophic Scars [PDF]

Journal of Pathology and Translational Medicine, 2018
Background Although several studies have shown the role of interleukin-31 (IL-31) and its receptors in inducing pruritus in certain skin disorders, knowledge of its role in post-burn hypertrophic scars is insufficient.
Mi Young Lee, Eun Shin, Hyunchul Kim, In Suk Kwak, Younghee Choi   +4 more
doaj   +2 more sources

Analyzing the Antinociceptive Effect of Interleukin-31 in Mice. [PDF]

Int J Mol Sci, 2023
The theory that an itch inhibits pain has been refuted; however, previous research did not investigate this theory for an interleukin-31 (IL-31)-induced itch. Previously, we have found that morphine-induced antinociception was partially reduced in IL-31 receptor A (IL-31RA)-deficient (IL-31RAKI) mice, indicating that IL-31RA may play an important role ...
Arai I, Tsuji M, Takahashi K, Saito S, Takeda H.   +4 more
europepmc   +4 more sources

Eosinophils are a Major Source of Interleukin-31 in Bullous Pemphigoid

Acta Dermato-Venereologica, 2018
Bullous pemphigoid (BP) is characterized by substantial skin and blood eosinophilia as well as intensive pruritus. Since the pruritogenic cytokine interleukin (IL)-31 is increased in inflammatory skin diseases the aim of this study was to determine ...
Urda Rüdrich, Manuela Gehring, Eleni Papakonstantinou, Anja Illerhaus, Judith Engmann, Alexander Kapp, Karin Hartmann, N. Helge Meyer, Bernhard F. Gibbs, Ulrike Raap   +9 more
doaj   +5 more sources

Helicobacter pylori eradication: influence of interleukin-1beta –31 C/T polymorphism

Brazilian Journal of Infectious Diseases, 2018
Aim: To analyze the influence of the –31 C/T polymorphism of the interleukin-1β gene on Helicobacter pylori eradication therapy success in patients with functional dyspepsia. Methods: Functional dyspepsia was diagnosed according to the Rome III criteria.
Tássia Flores Rech, Luiz Edmundo Mazzoleni, Felipe Mazzoleni, Carlos Fernando de Magalhães Francesconi, Guilherme Becker Sander, Rafael Tomoya Michita, Débora Dreher Nabinger, Tobias Cancian Milbradt, Ronaldo João Spinato Torresini, Daniel Simon   +9 more
doaj   +4 more sources