Results 11 to 20 of about 3,930,798 (267)

Interleukin-31: A Pro-inflammatory Oriented Cytokine

Frontiers in Bioscience-Landmark
Type 2 immunity is represented by T helper 2 (Th2) lymphocytes and the cytokines produced downstream (Interleukin (IL)-4, IL-13, IL-31). They are increasingly recognized as pivotal mediators in the pathogenesis of immune-mediated dermatological ...
Giuseppe Murdaca, Francesca Paladin, Andrea Orsi, Sebastiano Gangemi   +3 more
doaj   +5 more sources

Interleukin-31 in Respiratory Type 2 Inflammatory Diseases: Mechanistic Insights and Therapeutic Potential [PDF]

Journal of Inflammation Research
Shuang Yao,1,2,* Yan Zhao,1,2,* Zhimeng Li,3,4 Hongfei Lou,5,* Luo Zhang1,2,4,6,* 1Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, People’s Republic of ...
Yao S, Zhao Y, Li Z, Lou H, Zhang L
doaj   +4 more sources

Interleukin 31 receptor α promotes smooth muscle cell contraction and airway hyperresponsiveness in asthma [PDF]

Nature Communications, 2023
Asthma is a chronic inflammatory airway disease characterized by airway hyperresponsiveness (AHR), inflammation, and goblet cell hyperplasia. Multiple cytokines, including IFNγ, IL-4, and IL-13 are associated with asthma; however, the mechanisms ...
Santhoshi V. Akkenepally, Dan J. K. Yombo, Sanjana Yerubandi, Geereddy Bhanuprakash Reddy, Deepak A. Deshpande, Francis X. McCormack, Satish K. Madala   +6 more
doaj   +2 more sources

Oncostatin M suppresses IL31RA expression in dorsal root ganglia and interleukin-31-induced itching [PDF]

Frontiers in Immunology, 2023
BackgroundAtopic dermatitis (AD) is a chronic inflammatory skin disease characterized by intermittent itchy rash. Type 2 inflammatory cytokines such as interleukin (IL)-4, IL-13, and IL-31 are strongly implicated in AD pathogenesis.
Masataka Suehiro, Tomofumi Numata, Ryo Saito, Nozomi Yanagida, Chie Ishikawa, Kazue Uchida, Tomoko Kawaguchi, Yuhki Yanase, Yozo Ishiuji, John McGrath, Akio Tanaka   +10 more
doaj   +2 more sources

Interleukin-31 promotes fibrosis and T helper 2 polarization in systemic sclerosis [PDF]

Nature Communications, 2021
Systemic sclerosis (SSc) disease involves multisystem fibrosis and autoimmunity with limited treatment options. Here the authors demonstrate that IL-31 and IL-31RA are overexpressed in dermal fibroblasts from SSc patients and show that fibrosis and ...
Ai Kuzumi, Ayumi Yoshizaki, Kazuki M. Matsuda, Hirohito Kotani, Yuta Norimatsu, Maiko Fukayama, Satoshi Ebata, Takemichi Fukasawa, Asako Yoshizaki-Ogawa, Yoshihide Asano, Kyojiro Morikawa, Yutaka Kazoe, Kazuma Mawatari, Takehiko Kitamori, Shinichi Sato   +14 more
doaj   +2 more sources

Transmembrane protein TMEM184B is necessary for interleukin-31–induced itch [PDF]

Pain, 2021
Abstract Nociceptive and pruriceptive neurons in the dorsal root ganglia (DRG) convey sensations of pain and itch to the spinal cord, respectively. One subtype of mature DRG neurons, comprising 6% to 8% of neurons in the ganglia, is responsible for sensing mediators of acute itch and atopic dermatitis, including the cytokine IL-31.
Erik G. Larsen, Tiffany S. Cho, Matthew L. McBride, Jing Feng, Bhagyashree Manivannan, Cynthia Madura, Nathaniel E. Klein, Elizabeth B. Wright, Edward S. Wickstead, Hector D. Garcia-Verdugo, Chelsea Jarvis, Rajesh Khanna, Hongzhen Hu, Tally M. Largent-Milnes, Martha R.C. Bhattacharya   +14 more
openaire   +3 more sources

Interleukin-31 Receptor α Is Required for Basal-Like Breast Cancer Progression [PDF]

Frontiers in Oncology, 2020
Purpose: Interleukin-31 receptor α (IL31RA) usually mediates IL-31 induced inflammation and allergic diseases. However, the functional roles of IL-31/IL31RA signaling in basal-like breast cancer (BLBC) progression remain totally unclear.Methods ...
Yanling He, Xinyuan Zhang, Weijun Pan, Fang Tai, Li Liang, Jian Shi, Jian Shi   +6 more
doaj   +2 more sources

Itch in dermatomyositis: the role of increased skin interleukin-31 [PDF]

British Journal of Dermatology, 2018
Interleukin (IL)-31 is implicated in pruritus associated with pruritic skin diseases like atopic dermatitis. Although pruritus is a prominent feature in dermatomyositis (DM), few studies have evaluated the pathogenesis of DM-associated itch.To establish the prevalence of itch in DM, and to investigate the role of IL-31 in DM-related itch.Pruritus and ...
H.J. Kim, M. Zeidi, D. Bonciani, S.M. Pena, J. Tiao, S. Sahu, V.P. Werth   +6 more
openaire   +3 more sources

Interleukin-31: The Inflammatory Cytokine Connecting Pruritus and Cancer

Frontiers in Bioscience-Landmark
Interleukin 31 (IL-31) is a proinflammatory cytokine, mainly secreted by Type II helper T cells. It signals through a heterodimeric receptor complex composed of IL-31 receptor α and oncostatin-M receptor β chain.
Sabah Akhtar, Fareed Ahmad, Majid Alam, Abdul Wahid Ansari, Shahab Uddin, Martin Steinhoff, Joerg Buddenkotte, Aamir Ahmad, Angeliki Datsi   +8 more
doaj   +3 more sources

Interleukin-31, Interleukin-31RA, and OSMR Expression Levels in Post-burn Hypertrophic Scars [PDF]

Journal of Pathology and Translational Medicine, 2018
Background Although several studies have shown the role of interleukin-31 (IL-31) and its receptors in inducing pruritus in certain skin disorders, knowledge of its role in post-burn hypertrophic scars is insufficient.
Mi Young Lee, Eun Shin, Hyunchul Kim, In Suk Kwak, Younghee Choi   +4 more
doaj   +2 more sources