Interleukin-31 as a Clinical Target for Pruritus Treatment [PDF]
Frontiers in Medicine, 2021 In recent years, the published literature has suggested the key involvement of the cytokine interleukin-31 (IL-31) in the symptomatology of pruritus, and both IL-31 and its receptor have become potential therapeutic targets for a range of pruritic ...
Kenji Kabashima, Hiroyuki Irie
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Interleukin-31 in serum and cerebrospinal fluid of dogs with syringomyelia [PDF]
BMC Veterinary Research, 2023 Background Syringomyelia is a spinal cord cavity containing cerebrospinal fluid (CSF)-like fluid. If syringomyelia asymmetrically involves the dorsal horn grey matter of the spinal cord, affected dogs show increased signs of dysesthesia and neuropathic ...
Laura Lemke +6 more
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Interleukin-31 and Chronic Pruritus of Unknown Origin [PDF]
Biomarker Insights, 2020 Chronic pruritus of unknown origin (CPUO) is a refractory condition. The expression of Interleukin-31 (IL-31), a major pruritogenic cytokine, in CPUO patients has not been investigated.
Kanin Salao +4 more
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Interleukin-31 Signaling Bridges the Gap Between Immune Cells, the Nervous System and Epithelial Tissues [PDF]
Frontiers in Medicine, 2021 Pruritus represents one of the most common symptoms in dermatology and general medicine. Chronic pruritus severely impairs the quality of life of affected patients.
Jana Maria Nemmer +8 more
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Possible Association of Interleukin-31/-31RA Signalling and Basophils with Itch in Porokeratosis [PDF]
Acta Dermato-Venereologica, 2023 is missing (Short communication)
Satoshi Okuno +3 more
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In chronic spontaneous urticaria, IgE and C‐reactive protein are linked to distinct microRNAs and interleukin‐31 [PDF]
Clinical and Translational Allergy, 2023 Background Chronic spontaneous urticaria (CSU) is a common and disabling disease. Assessments of IgE and C‐reactive protein (CRP) are recommended in the diagnostic work‐up, but the role and clinical relevance of these biomarkers are not well ...
Ozge Sevil Karstarli Bakay +6 more
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Capsaicin suppresses interleukin-31-induced itching partially involved in inhibiting the expression of dorsal root ganglion interleukin-31 receptor A in male mice [PDF]
Neurobiology of Pain, 2022 To elucidate the mechanisms underlying the antipruritic effect of capsaicin, we investigated how topical application of capsaicin (0.01, 0.1 and 1.0% w/v) affects spontaneous scratching in NC/Nga mice, inerleukin-31 (IL-31) induced in BALB/c mice, and IL-
Iwao Arai +4 more
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Interleukin 31 receptor α promotes smooth muscle cell contraction and airway hyperresponsiveness in asthma [PDF]
Nature Communications, 2023 Asthma is a chronic inflammatory airway disease characterized by airway hyperresponsiveness (AHR), inflammation, and goblet cell hyperplasia. Multiple cytokines, including IFNγ, IL-4, and IL-13 are associated with asthma; however, the mechanisms ...
Santhoshi V. Akkenepally +6 more
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Increased serum interleukin-31 levels correlate with pruritus in psoriatic patients: a cross-sectional study in Vietnam [PDF]
Dermatology ReportsPsoriasis is recognized not only as a skin disease but also as a systemic disorder. Interleukin-31 (IL-31) may be associated with psoriasis and systemic inflammation.
Chuyen Thi Hong Nguyen +1 more
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Oncostatin M suppresses IL31RA expression in dorsal root ganglia and interleukin-31-induced itching [PDF]
Frontiers in Immunology, 2023 BackgroundAtopic dermatitis (AD) is a chronic inflammatory skin disease characterized by intermittent itchy rash. Type 2 inflammatory cytokines such as interleukin (IL)-4, IL-13, and IL-31 are strongly implicated in AD pathogenesis.
Masataka Suehiro +10 more
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