Results 31 to 40 of about 57,029,053 (268)

Pruritus as a Distinctive Feature of Type 2 Inflammation

Vaccines, 2021
Pruritus is a common symptom of several skin diseases, both inflammatory and neoplastic. Pruritus might have a tremendous impact on patients’ quality of life and strongly interfere with sleep, social, and work activities.
Simone Garcovich, Martina Maurelli, Paolo Gisondi, Ketty Peris, Gil Yosipovitch, Giampiero Girolomoni   +5 more
doaj   +1 more source

Interleukin‐31: The “itchy” cytokine in inflammation and therapy [PDF]

Allergy, 2020
AbstractThe cytokine interleukin‐31 has been implicated in the pathophysiology of multiple atopic disorders such as atopic dermatitis (AD), allergic rhinitis, and airway hyper‐reactivity. In AD, IL‐31 has been identified as one of the main “drivers” of its cardinal symptom, pruritus.
Angeliki Datsi, Martin Steinhoff, Fareed Ahmad, Majid Alam, Joerg Buddenkotte   +4 more
openaire   +3 more sources

Emerging role of interleukin‐31 and interleukin‐31 receptor in pruritus in atopic dermatitis [PDF]

Allergy, 2017
AbstractAtopic dermatitis (AD) is a chronic or chronically relapsing, eczematous, severely pruritic skin disorder associated with skin barrier dysfunction. The lesional skin of AD exhibits T helper 2 (TH2)‐deviated immune reactions. Interleukin‐31 (IL‐31), preferentially produced from TH2 cells, is a potent pruritogenic cytokine, and its systemic and ...
M. Furue, K. Yamamura, M. Kido‐Nakahara, T. Nakahara, Y. Fukui   +4 more
openaire   +2 more sources

Significance of interleukin-31 (IL-31) gene polymorphisms and IL-31 serum level in psoriasis in correlation with pruritus. [PDF]

Postepy Dermatol Alergol, 2021
Interleukin-31 (IL-31) impact on the development and clinical presentation of psoriasis as well as pruritus has not been widely investigated so far.To analyse IL-31 -1066G/A and -2057G/A promoter gene polymorphisms as well as serum IL-31 level and their correlation with severity of psoriasis and pruritus in the population of northern Poland.The study ...
Purzycka-Bohdan D, Gleñ J, Zabłotna M, Nedoszytko B, Szczerkowska-Dobosz A, Sokołowska-Wojdyło M, Rêbała K, Nowicki RJ.   +7 more
europepmc   +4 more sources

Interleukin‐31 and interleukin‐31 receptor: New therapeutic targets for atopic dermatitis [PDF]

Experimental Dermatology, 2018
AbstractAtopic dermatitis (AD) is characterized by chronic, eczematous, severe pruritic skin lesions caused by skin barrier dysfunction and T helper (Th)2 cell‐mediated immunity. Interleukin (IL)‐31 is a potent pruritogenic cytokine primarily produced by Th2 cells.
Chisa Nakashima, Atsushi Otsuka, Kenji Kabashima   +2 more
openaire   +2 more sources

The Acute Phase Reaction and Its Prognostic Impact in Patients with Head and Neck Squamous Cell Carcinoma: Single Biomarkers Including C-Reactive Protein Versus Biomarker Profiles

Biomedicines, 2020
C-reactive protein (CRP) has a prognostic impact in head and neck squamous cell carcinoma (HNSCC). However, the acute phase reaction involves many other proteins depending on its inducing events, including various cytokines that can function as reaction ...
Helene Hersvik Aarstad, Svein Erik Emblem Moe, Øystein Bruserud, Stein Lybak, Hans Jørgen Aarstad, Tor Henrik Anderson Tvedt   +5 more
doaj   +1 more source

Interleukin-31 new biomarker of infectious skin diseases

Journal of V. N. Karazin Kharkiv National University: Series Medicine, 2021
Introduction. The introduction of antiretroviral therapy has significantly improved the long-term prognosis of AIDS patients, but opportunistic infections can still be life-threatening for this population.
Diana Dorosh
doaj   +1 more source

Definition and Characterization of an Inhibitor for Interleukin-31 [PDF]

Journal of Biological Chemistry, 2010
Interleukin-31 (IL-31) is a recently described T cell-derived cytokine, mainly produced by T helper type 2 cells and related to the IL-6 cytokine family according to its structure and receptor. IL-31 is the ligand for a heterodimeric receptor composed of a gp130-like receptor (GPL) associated with the oncostatin M receptor (OSMR).
Venereau, Emilie, Diveu, Caroline, Grimaud, Linda, Ravon, Elisa, Froger, Josy, Preisser, Laure, Danger, Yannic, Maillasson, Mike, Garrigue-Antar, Laure, Jacques, Yannick, Chevalier, Sylvie, Gascan, Hugues   +11 more
openaire   +3 more sources

Increased levels of interleukin 31 (IL-31) in osteoporosis. [PDF]

BMC Immunol, 2015
Several inflammatory cytokines play a key part in the induction of osteoporosis. Until now, involvement of the Th2 cytokine interleukin-31 (IL-31) in osteoporosis hadn't yet been studied. IL-31 is a proinflammatory cytokine mediating multiple immune functions, whose involvement in a wide range of diseases, such as atopic dermatitis, inflammatory bowel ...
Ginaldi L, De Martinis M, Ciccarelli F, Saitta S, Imbesi S, Mannucci C, Gangemi S.   +6 more
europepmc   +6 more sources

Establishment of an Intradermal Canine IL-31-Induced Pruritus Model to Evaluate Therapeutic Candidates in Atopic Dermatitis

Veterinary Sciences, 2023
Pruritic models in healthy dogs utilizing intravenous administration of interleukin 31 (IL-31) bypass the “natural” itch sensation in AD, which is initiated by pruriceptive primary afferent neurons in the skin.
Jason Pearson, Renato Leon, Haley Starr, Sujung Jun Kim, Jonathan E. Fogle, Frane Banovic   +5 more
doaj   +1 more source