Results 1 to 10 of about 415,727 (126)

Significance of interleukin-31 (IL-31) gene polymorphisms and IL-31 serum level in psoriasis in correlation with pruritus. [PDF]

Postepy Dermatol Alergol, 2021
Interleukin-31 (IL-31) impact on the development and clinical presentation of psoriasis as well as pruritus has not been widely investigated so far.To analyse IL-31 -1066G/A and -2057G/A promoter gene polymorphisms as well as serum IL-31 level and their correlation with severity of psoriasis and pruritus in the population of northern Poland.The study ...
Purzycka-Bohdan D, Gleñ J, Zabłotna M, Nedoszytko B, Szczerkowska-Dobosz A, Sokołowska-Wojdyło M, Rêbała K, Nowicki RJ.   +7 more
europepmc   +4 more sources

Increased levels of interleukin 31 (IL-31) in osteoporosis. [PDF]

BMC Immunol, 2015
Several inflammatory cytokines play a key part in the induction of osteoporosis. Until now, involvement of the Th2 cytokine interleukin-31 (IL-31) in osteoporosis hadn't yet been studied. IL-31 is a proinflammatory cytokine mediating multiple immune functions, whose involvement in a wide range of diseases, such as atopic dermatitis, inflammatory bowel ...
Ginaldi L, De Martinis M, Ciccarelli F, Saitta S, Imbesi S, Mannucci C, Gangemi S.   +6 more
europepmc   +6 more sources

Mechanisims of asthma and allergic disease – 1064. Interleukin 31 (IL 31) serum levels in atopic dermatitis patients [PDF]

World Allergy Organ J, 2013
Background Atopic dermatitis is a common chronic skin disorder which is a subset of atopy. Atopy refers to a genetic predisposition to respond immunonologically to allergens which are generally harmless, causingover production of immunoglobulin E (IgE) antibodies.
Mohd Ashari N, Syuhada S, Mustaffa M, Wah W, Azriani A, Zulrushydi I.   +5 more
europepmc   +3 more sources

Determination of interleukin 31 (IL-31) serum levels in allergic rhinitis patients

International Journal of Pediatrics & Adolescent Medicine, 2014
Background and objectives: IL-31 appears to be an important regulator of Th2 re-sponses and was found to be present in patients with atopic dermatitis. This study was con-ducted to compare IL-31 serum levels in allergic rhinitis (AR) patients and normal ...
Noor Suryani Mohd Ashari, Siti Noor Syuhada Mohd Amin, Wan Zuraida Wan Abdul Hamid, Mustaffa Musa, Azriani Abdul Rahman, Irfan Mohamad   +5 more
doaj   +2 more sources

Interleukin-31 as a Clinical Target for Pruritus Treatment

Frontiers in Medicine, 2021
In recent years, the published literature has suggested the key involvement of the cytokine interleukin-31 (IL-31) in the symptomatology of pruritus, and both IL-31 and its receptor have become potential therapeutic targets for a range of pruritic ...
Kenji Kabashima, Hiroyuki Irie
doaj   +1 more source

Blockage of the IL-31 Pathway as a Potential Target Therapy for Atopic Dermatitis

Pharmaceutics, 2023
Atopic dermatitis (AD), a pruritic, inflammatory chronic disease with multifactorial pathogenesis, has been a therapeutic challenge. Novel target treatments aim to reduce not only the immunologic dysfunction and microbiome dysbiosis but also the recovery
Raquel Leao Orfali, Valeria Aoki
doaj   +1 more source

The Protective Effects of IL-31RA Deficiency During Bleomycin-Induced Pulmonary Fibrosis

Frontiers in Immunology, 2021
Idiopathic Pulmonary Fibrosis (IPF) is a severe fibrotic lung disease characterized by excessive collagen deposition and progressive decline in lung function.
Dan J. K. Yombo, Dan J. K. Yombo, Varshini Odayar, Varshini Odayar, Nishant Gupta, Anil G. Jegga, Anil G. Jegga, Satish K. Madala, Satish K. Madala   +8 more
doaj   +1 more source

Capsaicin suppresses interleukin-31-induced itching partially involved in inhibiting the expression of dorsal root ganglion interleukin-31 receptor A in male mice

Neurobiology of Pain, 2022
To elucidate the mechanisms underlying the antipruritic effect of capsaicin, we investigated how topical application of capsaicin (0.01, 0.1 and 1.0% w/v) affects spontaneous scratching in NC/Nga mice, inerleukin-31 (IL-31) induced in BALB/c mice, and IL-
Iwao Arai, Minoru Tsuji, Hiroshi Takeda, Nobutake Akiyama, Saburo Saito   +4 more
doaj   +1 more source

Interleukin-31 in serum and cerebrospinal fluid of dogs with syringomyelia

BMC Veterinary Research, 2023
Background Syringomyelia is a spinal cord cavity containing cerebrospinal fluid (CSF)-like fluid. If syringomyelia asymmetrically involves the dorsal horn grey matter of the spinal cord, affected dogs show increased signs of dysesthesia and neuropathic ...
Laura Lemke, Regina Carlson, Thomas Flegel, Andrea Volk, Holger Andreas Volk, Andrea Tipold, Jasmin Nicole Nessler   +6 more
doaj   +1 more source

Efficacy and safety of vixarelimab, a human monoclonal oncostatin M receptor β antibody, in moderate-to-severe prurigo nodularis: a randomised, double-blind, placebo-controlled, phase 2a studyResearch in context

EClinicalMedicine, 2023
Summary: Background: Prurigo nodularis is a chronic skin disease characterised by intensely pruritic, hyperkeratotic nodules. Vixarelimab, a human monoclonal antibody, binds to the beta subunit of the oncostatin M receptor, inhibiting signalling of both
Howard Sofen, Robert Bissonnette, Gil Yosipovitch, Jonathan I. Silverberg, Stephen Tyring, Wei Jing Loo, Matthew Zook, Mark Lee, Liangxing Zou, Guang-Liang Jiang, John F. Paolini   +10 more
doaj   +1 more source