Results 11 to 20 of about 68,824,737 (161)

IL-31-Driven Skin Remodeling Involves Epidermal Cell Proliferation and Thickening That Lead to Impaired Skin-Barrier Function. [PDF]

PLoS ONE, 2016
Interleukin-31 (IL-31) is a type 2 helper T-cell-derived cytokine that has recently been shown to cause severe inflammation and tissue remodeling in multiple chronic diseases of the skin and lungs.
Brijendra Singh, Anil G Jegga, Kumar S Shanmukhappa, Ramakrishna Edukulla, Gurjit H Khurana Hershey, Mario Medvedovic, Stacey R Dillon, Satish K Madala   +7 more
doaj   +2 more sources

Interleukin-31: A Pro-inflammatory Oriented Cytokine

Frontiers in Bioscience-Landmark
Type 2 immunity is represented by T helper 2 (Th2) lymphocytes and the cytokines produced downstream (Interleukin (IL)-4, IL-13, IL-31). They are increasingly recognized as pivotal mediators in the pathogenesis of immune-mediated dermatological ...
Giuseppe Murdaca, Francesca Paladin, Andrea Orsi, Sebastiano Gangemi   +3 more
doaj   +2 more sources

IL-31 induces antitumor immunity in breast carcinoma

Journal for ImmunoTherapy of Cancer, 2020
Background Immunomodulatory agents that induce antitumor immunity have great potential for treatment of cancer. We have previously shown that interleukin (IL)-31, a proinflammatory cytokine from the IL-6 family, acts as an antiangiogenic agent.
Tal Kan, Erik Feldman, Michael Timaner, Ziv Raviv, Shai Shen-Orr, Ami Aronheim, Yuval Shaked   +6 more
doaj   +2 more sources

Interleukin-31, Interleukin-31RA, and OSMR Expression Levels in Post-burn Hypertrophic Scars [PDF]

Journal of Pathology and Translational Medicine, 2018
Background Although several studies have shown the role of interleukin-31 (IL-31) and its receptors in inducing pruritus in certain skin disorders, knowledge of its role in post-burn hypertrophic scars is insufficient.
Mi Young Lee, Eun Shin, Hyunchul Kim, In Suk Kwak, Younghee Choi   +4 more
doaj   +2 more sources

Profile of Serum Interleukin-31 Levels in Atopic Dermatitis [PDF]

Berkala Ilmu Kesehatan Kulit dan Kelamin (Periodical of Dermatology and Venerology), 2017
Background: Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by pruritic skin lesion. Pathogenesis of AD is not fully understood, but recent studies demonstrate the role of interleukin-31 (IL-31).
Dewi Kusumawati, Cita Rosita Prakoeswa, Rahmadewi Rahmadewi   +2 more
doaj   +3 more sources

Interleukin-31: The Inflammatory Cytokine Connecting Pruritus and Cancer

Frontiers in Bioscience-Landmark
Interleukin 31 (IL-31) is a proinflammatory cytokine, mainly secreted by Type II helper T cells. It signals through a heterodimeric receptor complex composed of IL-31 receptor α and oncostatin-M receptor β chain.
Sabah Akhtar, Fareed Ahmad, Majid Alam, Abdul Wahid Ansari, Shahab Uddin, Martin Steinhoff, Joerg Buddenkotte, Aamir Ahmad, Angeliki Datsi   +8 more
doaj   +2 more sources

Assessment of IL-13, IL-31 Levels and Disease Severity in Children with Atopic Dermatitis

Dermato
Introduction: Atopic dermatitis (AD) is driven by complex pathways that mediate inflammation and pruritus. The pathophysiology of AD’s disease involves multiple pathways.
Sara Missaoui, Imane Abbari, Halima Kholaiq, Zahra Aadam, Khaoula Oussama, Abdelrrahmane Errami, Fatima Ailal, Ibtihal Benhsaien, Bouchra Baghad, Jalila El Bakkouri, Ahmed Aziz Bousfiha   +10 more
doaj   +2 more sources

Effects of seasonal changes on T-helper 1/ T-helper 2 immune balance and eczema onset in rats

Journal of Traditional Chinese Medical Sciences, 2023
Objective: To explore the impact of seasonal changes on the T-helper 1 (Th1)/T-helper 2 (Th2) immune balance of the body in order to elucidate the internal immunological mechanisms underlying seasonal eczema.
Hairong Zhang, Leilei Liu, Yike Sun, Wenna Li, Ruochong Wang, Xiao Sun, Guangqin Zhu, Shuran Ma   +7 more
doaj   +1 more source

The IL-33/IL-31 Axis in Allergic and Immune-Mediated Diseases

, 2023
Interleukin 31 (IL-31) belongs to the IL-6 superfamily [...
Monica Greco, Giuseppe Murdaca, Sebastiano Gangemi, Greco, Monica, Gangemi, Sebastiano, Murdaca, Giuseppe   +5 more
core   +1 more source

Interleukin-31 and Pruritic Skin

, 2021
Skin inflammation often evokes pruritus, which is the major subjective symptom in many inflammatory skin diseases such as atopic dermatitis and prurigo nodularis. Pruritus or itch is a specific sensation found only in the skin.
Masutaka Furue, Mihoko Furue
core   +1 more source