Results 41 to 50 of about 68,824,737 (161)

A common variant of the interleukin 6 receptor (IL-6r) gene increases IL-6r and IL-6 levels, without other inflammatory effects.

, 2007
Interleukin-6 (IL-6) is a key inflammatory cytokine, signalling to most tissues by binding to a soluble IL-6 receptor (sIL-6r), making a complex with gp130.
A Murray, Henley, W, Bandinelli, S, S Rafiq, Rafiq, S, Weedon, MN, Guralnik, JM, Hurst, A, A-M Corsi, Ferrucci, L, K Stevens, S Bandinelli, M N Weedon, Corsi, A-M, L Ferrucci, Murray, A, D Melzer, W Henley, T M Frayling, J M Guralnik, A Hurst, Stevens, K, Melzer, D, Frayling, TM   +23 more
core   +1 more source

Oncostatin M Induction of Monocyte Chemoattractant Protein 1 is Inhibited by Anti-oncostatin M Receptor Beta Monoclonal Antibody KPL-716

Acta Dermato-Venereologica, 2020
To evaluate cellular response to oncostatin M (OSM) in comparison to interleukin (IL)-31, we analyzed monocyte chemoattractant protein 1 (MCP-1) as a readout for OSM responses with and without IL-4, IL-13, anti-OSM receptor β monoclonal antibody KPL-716,
Carl D. Richards, Rohan Gandhi, Fernando Botelho, Lilian Ho, John F. Paolini   +4 more
doaj   +1 more source

Increased serum IL-31 levels in chronic spontaneous urticaria and psoriasis with pruritic symptoms

Heliyon, 2020
Background: Chronic spontaneous urticaria (CSU) is a common pruritic skin condition, the pathogenesis of which remains unclear. Interleukin-31 (IL-31) is a major pruritogenic cytokine that plays a role in inducing pruritus in various skin diseases. Aim.:
Suteeraporn Chaowattanapanit, Charoen Choonhakarn, Kanin Salao, Kengkart Winaikosol, Narachai Julanon, Rachot Wongjirattikarn, Chingching Foocharoen, Mongkhon Sompornrattanaphan   +7 more
doaj   +1 more source

The Serum Level of IL-31 in Patients with Chronic Kidney Disease-Associated Pruritus: What Can We Expect?

Toxins, 2022
Chronic-kidney-disease-associated pruritus (CKD-aP) is one of the most common and burdensome dermatological symptoms affecting patients undergoing dialysis, and its etiopathogenesis has still not been fully discovered.
Karolina Świerczyńska, Piotr K. Krajewski, Danuta Nowicka-Suszko, Rafał Białynicki-Birula, Magdalena Krajewska, Jacek C. Szepietowski   +5 more
doaj   +1 more source

The role of interleukin-1 gene polymorphisms and Helicobacter pylori in gastroesophageal reflux disease

The Turkish Journal of Gastroenterology, 2014
Background/Aims: Our aim is to assess the relationship between interleukin 1β (IL-1 β), (-511,-31 alleles), interleukin 1RN (IL-RN), Helicobacter pylori (HP) status and gastroesophageal reflux disease (GERD) diagnosed by pH monitoring in the ...
Gülhan Akçil, İbrahim Doğan, Mustafa Cengiz, Evren Doruk Engin, Mehmet Doğan, Selahattin Ünal, Meltem Yalınay Çırak, Ayşe Dursun   +7 more
doaj   +1 more source

Eosinophils are a Major Source of Interleukin-31 in Bullous Pemphigoid

Acta Dermato-Venereologica, 2018
Bullous pemphigoid (BP) is characterized by substantial skin and blood eosinophilia as well as intensive pruritus. Since the pruritogenic cytokine interleukin (IL)-31 is increased in inflammatory skin diseases the aim of this study was to determine ...
Urda Rüdrich, Manuela Gehring, Eleni Papakonstantinou, Anja Illerhaus, Judith Engmann, Alexander Kapp, Karin Hartmann, N. Helge Meyer, Bernhard F. Gibbs, Ulrike Raap   +9 more
doaj   +1 more source

Prevention of arthritis by interleukin 10-producing B cells [PDF]

, 2003
In this study we have shown that activation of arthritogenic splenocytes with antigen and agonistic anti-CD40 gives raise to a B cell population that produce high levels of interleukin (IL)-10 and low levels of interferon (IFN)-{gamma}. Transfer of these
Mauri, C., Mushtaq, N., Marco Londei, Claudia Mauri, Naseem Mushtaq, Gray, D., Londei, M., David Gray   +7 more
core   +1 more source

IL-31: State of the Art for an Inflammation-Oriented Interleukin

, 2022
Interleukin 31 belongs to the IL-6 superfamily, and it is an itch mediator already studied in several diseases, comprising atopic dermatitis, allergic pathologies, and onco-hematological conditions.
Borgia, Francesco, Custurone, Paolo, Sebastiano Gangemi, Cordiano, Raffaele, Alessandrello, Clara, Federica Li Pomi, Li Pomi, Federica, Gangemi, Sebastiano, Paolo Custurone, Francesco Borgia, Clara Alessandrello, Raffaele Cordiano   +11 more
core   +1 more source

IL-31 associated with coronary artery lesion formation in Kawasaki disease. [PDF]

PLoS ONE, 2014
Kawasaki disease (KD) is known to be associated with T help (Th) 2 reaction and subsequently allergic diseases. Interleukin-31 (IL-31) has also been reported to be involved in Th2 mediated diseases such as allergic diseases. However, the role of IL-31 in
Wan-Ning Tseng, Mao-Hung Lo, Mindy Ming-Huey Guo, Kai-Sheng Hsieh, Wei-Chiao Chang, Ho-Chang Kuo   +5 more
doaj   +1 more source

[Translated article] Nemolizumab: An Innovative Biologic Treatment to Control Interleukin 31, a Key Mediator in Atopic Dermatitis and Prurigo Nodularis

Actas Dermo-Sifiliográficas, 2022
Interleukin 31 (IL-31) is a neurocytokine that stimulates sensory neurons involved in pruritus. It contributes to skin barrier inflammation, dysfunction, and remodeling.
E. Serra-Baldrich, L.F. Santamaria-Babí, J. Francisco Silvestre   +2 more
doaj   +1 more source