Results 31 to 40 of about 56,984,652 (272)
Interleukin‐31 and interleukin‐31 receptor: New therapeutic targets for atopic dermatitis [PDF]
Experimental Dermatology, 2018 AbstractAtopic dermatitis (AD) is characterized by chronic, eczematous, severe pruritic skin lesions caused by skin barrier dysfunction and T helper (Th)2 cell‐mediated immunity. Interleukin (IL)‐31 is a potent pruritogenic cytokine primarily produced by Th2 cells.
Chisa Nakashima +2 more
openaire +2 more sources
Transmembrane protein TMEM184B is necessary for interleukin-31-induced itch. [PDF]
Pain, 2022 Abstract Nociceptive and pruriceptive neurons in the dorsal root ganglia (DRG) convey sensations of pain and itch to the spinal cord, respectively. One subtype of mature DRG neurons, comprising 6% to 8% of neurons in the ganglia, is responsible for sensing mediators of acute itch and atopic dermatitis, including the cytokine IL-31.
Larsen EG +14 more
europepmc +3 more sources
Definition and Characterization of an Inhibitor for Interleukin-31 [PDF]
Journal of Biological Chemistry, 2010 Interleukin-31 (IL-31) is a recently described T cell-derived cytokine, mainly produced by T helper type 2 cells and related to the IL-6 cytokine family according to its structure and receptor. IL-31 is the ligand for a heterodimeric receptor composed of a gp130-like receptor (GPL) associated with the oncostatin M receptor (OSMR).
Venereau, Emilie +11 more
openaire +3 more sources
Toxins, 2022 Chronic-kidney-disease-associated pruritus (CKD-aP) is one of the most common and burdensome dermatological symptoms affecting patients undergoing dialysis, and its etiopathogenesis has still not been fully discovered.
Karolina Świerczyńska +5 more
doaj +1 more source
Frontiers in Immunology, 2021 Atopic dermatitis (AD) is a multifaceted, chronic relapsing inflammatory skin disease that affects people of all ages. It is characterized by chronic eczema, constant pruritus, and severe discomfort. AD often progresses from mild annoyance to intractable
Jianghui Meng +12 more
doaj +1 more source
, 2003 Interleukin-18 (IL-18), a recently described member of the IL-1 cytokine superfamily, is now recognized as an important regulator of innate and acquired immune responses.
McInnes, I.B. +2 more
core +1 more source
Interleukin-6 level in pediatric patients with COVID-19.
, 2023 Interleukin-6 level in pediatric patients with COVID-19.
Bahrul Fikri (17296062) +8 more
core +1 more source
Veterinary Sciences, 2023 Pruritic models in healthy dogs utilizing intravenous administration of interleukin 31 (IL-31) bypass the “natural” itch sensation in AD, which is initiated by pruriceptive primary afferent neurons in the skin.
Jason Pearson +5 more
doaj +1 more source
Itch in dermatomyositis: the role of increased skin interleukin-31. [PDF]
Br J Dermatol, 2018 Interleukin (IL)-31 is implicated in pruritus associated with pruritic skin diseases like atopic dermatitis. Although pruritus is a prominent feature in dermatomyositis (DM), few studies have evaluated the pathogenesis of DM-associated itch.To establish the prevalence of itch in DM, and to investigate the role of IL-31 in DM-related itch.Pruritus and ...
Kim HJ +6 more
europepmc +4 more sources
Interleukin-31 new biomarker of infectious skin diseases
Journal of V. N. Karazin Kharkiv National University: Series Medicine, 2021 Introduction. The introduction of antiretroviral therapy has significantly improved the long-term prognosis of AIDS patients, but opportunistic infections can still be life-threatening for this population.
Diana Dorosh
doaj +1 more source