Results 31 to 40 of about 3,930,798 (267)

Interleukin‐31: The “itchy” cytokine in inflammation and therapy [PDF]

open access: yesAllergy, 2020
AbstractThe cytokine interleukin‐31 has been implicated in the pathophysiology of multiple atopic disorders such as atopic dermatitis (AD), allergic rhinitis, and airway hyper‐reactivity. In AD, IL‐31 has been identified as one of the main “drivers” of its cardinal symptom, pruritus.
Angeliki Datsi   +4 more
openaire   +3 more sources

Emerging role of interleukin‐31 and interleukin‐31 receptor in pruritus in atopic dermatitis [PDF]

open access: yesAllergy, 2017
AbstractAtopic dermatitis (AD) is a chronic or chronically relapsing, eczematous, severely pruritic skin disorder associated with skin barrier dysfunction. The lesional skin of AD exhibits T helper 2 (TH2)‐deviated immune reactions. Interleukin‐31 (IL‐31), preferentially produced from TH2 cells, is a potent pruritogenic cytokine, and its systemic and ...
M. Furue   +4 more
openaire   +2 more sources

Interleukin‐31 and interleukin‐31 receptor: New therapeutic targets for atopic dermatitis [PDF]

open access: yesExperimental Dermatology, 2018
AbstractAtopic dermatitis (AD) is characterized by chronic, eczematous, severe pruritic skin lesions caused by skin barrier dysfunction and T helper (Th)2 cell‐mediated immunity. Interleukin (IL)‐31 is a potent pruritogenic cytokine primarily produced by Th2 cells.
Chisa Nakashima   +2 more
openaire   +2 more sources

Definition and Characterization of an Inhibitor for Interleukin-31 [PDF]

open access: yesJournal of Biological Chemistry, 2010
Interleukin-31 (IL-31) is a recently described T cell-derived cytokine, mainly produced by T helper type 2 cells and related to the IL-6 cytokine family according to its structure and receptor. IL-31 is the ligand for a heterodimeric receptor composed of a gp130-like receptor (GPL) associated with the oncostatin M receptor (OSMR).
Venereau, Emilie   +11 more
openaire   +3 more sources

The Serum Level of IL-31 in Patients with Chronic Kidney Disease-Associated Pruritus: What Can We Expect?

open access: yesToxins, 2022
Chronic-kidney-disease-associated pruritus (CKD-aP) is one of the most common and burdensome dermatological symptoms affecting patients undergoing dialysis, and its etiopathogenesis has still not been fully discovered.
Karolina Świerczyńska   +5 more
doaj   +1 more source

Th2 Modulation of Transient Receptor Potential Channels: An Unmet Therapeutic Intervention for Atopic Dermatitis

open access: yesFrontiers in Immunology, 2021
Atopic dermatitis (AD) is a multifaceted, chronic relapsing inflammatory skin disease that affects people of all ages. It is characterized by chronic eczema, constant pruritus, and severe discomfort. AD often progresses from mild annoyance to intractable
Jianghui Meng   +12 more
doaj   +1 more source

Interleukin-18 [PDF]

open access: yes, 2003
Interleukin-18 (IL-18), a recently described member of the IL-1 cytokine superfamily, is now recognized as an important regulator of innate and acquired immune responses.
McInnes, I.B.   +2 more
core   +1 more source

Differential regulation of interleukin-17 and interferon-y production in inflammatory bowel disease [PDF]

open access: yes, 2010
PhDBackground and Aims. Interleukin (IL)-17 is now known to be involved in a number of chronic inflammatory disorders. However, the mechanisms regulating its production in inflammatory bowel disease (IBD) are still unclear. Methods.
Rovedatti, Laura
core   +4 more sources

Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies [PDF]

open access: yes, 2012
BACKGROUND: Persistent inflammation has been proposed to contribute to various stages in the pathogenesis of cardiovascular disease. Interleukin-6 receptor (IL6R) signalling propagates downstream inflammation cascades.
Thomas, GN   +492 more
core   +1 more source

Establishment of an Intradermal Canine IL-31-Induced Pruritus Model to Evaluate Therapeutic Candidates in Atopic Dermatitis

open access: yesVeterinary Sciences, 2023
Pruritic models in healthy dogs utilizing intravenous administration of interleukin 31 (IL-31) bypass the “natural” itch sensation in AD, which is initiated by pruriceptive primary afferent neurons in the skin.
Jason Pearson   +5 more
doaj   +1 more source

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