Results 61 to 70 of about 8,409,985 (265)

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

Divergent in situ expression of IL-31 and IL-31RA between bullous pemphigoid and pemphigus vulgaris [PDF]

, 2023
Bullous pemphigoid (BP) and pemphigus vulgaris (PV) are two major autoimmune blistering skin diseases. Unlike PV, BP is accompanied by intense pruritus, suggesting possible involvement of the pruritogenic cytokine IL-31.
Flaig M. J., Aoki R., French L. E., Ergun E. Z., Calabrese L., Hartmann D., Bagci I. S., Manav V., Horvath O. N., Sardy M., Gurel M. S., Ruzicka T., Aksu A. E. K., Satoh T. K.   +13 more
core   +1 more source

Social Functioning Within the First Years After Pediatric Brain Tumor Diagnosis and the Relationship With Family Psychosocial Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben, Marisa H. Huisman, Martha A. Grootenhuis, Femke K. Aarsen, Marita Partanen   +4 more
wiley   +1 more source

TMEM184b is necessary for IL-31 induced itch [PDF]

, 2020
Abstract Nociceptive and pruriceptive neurons in the dorsal root ganglia (DRG) convey sensations of pain and itch to the spinal cord, respectively. One subtype of mature DRG neurons, comprising about 5% of neurons in the ganglia, is responsible for sensing mediators of acute itch and atopic dermatitis, including the ...
Erik G. Larsen, Tiffany S. Cho, Matthew L. McBride, Jing Feng, Bhagyashree Manivannan, Cynthia Madura, Nathaniel E. Klein, Elizabeth B. Wright, Hector D. Garcia-Verdugo, Chelsea Jarvis, Rajesh Khanna, Hongzhen Hu, Tally M. Largent-Milnes, Martha R.C. Bhattacharya   +13 more
openaire   +1 more source

Effect of Luteolin and Apigenin on the Production of Il-31 and Il-33 in Lipopolysaccharides-Activated Microglia Cells and Their Mechanism of Action

, 2020
Microglia cells are resident cells of the central nervous system (CNS) charged with modulating inflammation in the CNS. Overstimulation of microglia cells continuously releases inflammatory mediators that contribute to neurodegenerative diseases ...
Byoung Ok Cho, Jae Young Shin, Ji-su Kim, Hyun Ju Kang, Denis Nchang Che, Seon Il Jang   +5 more
core   +1 more source

The release of IL-31 and IL-13 after nasal allergen challenge and their relation to nasal symptoms

Clinical and Translational Allergy, 2012
Background IL-31, a recently discovered member of the gp130/IL-6 cytokine family, is mainly expressed by human mast cells and T helper type 2 cells. IL-31 is a key trigger of atopic dermatitis.
Baumann Ralf, Rabaszowski Matthaeus, Stenin Igor, Gaertner-Akerboom Maria, Scheckenbach Kathrin, Wiltfang Jens, Schipper Joerg, Wagenmann Martin   +7 more
doaj   +1 more source

Immune regulation in pathophysiology and targeted therapy for itch in atopic dermatitis

Dermatologica Sinica, 2016
Itch is an unpleasant perception that provokes one to desire to scratch. It results from the activation of free nerve endings by noxious stimuli in the skin.
Chih-Hung Lee
doaj   +1 more source

Basophils in pruritic skin diseases

Frontiers in Immunology, 2023
Basophils are rare cells in the peripheral blood which have the capability to infiltrate into the skin. Invasion of basophils has been detected in pruritic skin diseases, including atopic dermatitis, bullous pemphigoid, chronic spontaneous urticaria and ...
Daniela Wiebe, Maren M. Limberg, Natalie Gray, Natalie Gray, Ulrike Raap, Ulrike Raap, Ulrike Raap   +6 more
doaj   +1 more source

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source