Results 281 to 290 of about 4,627,366 (384)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Single-cell multiomics uncovers an endothelial mechanosensitive PIEZO1-IL-33 axis driving pulmonary fibrosis. [PDF]

Nat Commun
Zhang L, Gui X, Hou R, Jia L, Xia S, Zhang X, Fu Y, Meng QF, Luo Q, Shi X, Guo B, Liang R, Yue L, Chen X, Xu H, Wang P, Tong X, Liu L, Wang L, Li B, Chen Z, Zhou L, Zhang L, Chen R, Sun C, Xu W, Rao L, Zhou H, Ding BS, Chen S.   +29 more
europepmc   +1 more source

IL-33 Markedly Activates Murine Eosinophils by an NF-κB–Dependent Mechanism Differentially Dependent upon an IL-4–Driven Autoinflammatory Loop [PDF]

, 2013
Carine Bouffi, Mark Rochman, Christopher B. Zust, Emily M. Stucke, Andrey Kartashov, Patricia C. Fulkerson, Artem Barski, Marc E. Rothenberg   +7 more
openalex   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Expression Analysis of JCAD and IL-33 in Gingival Cancer Tumor Angiogenesis. [PDF]

Cancers (Basel)
Shirai T, Kakei Y, Muraki Y, Nagano T, Suraya R, Uryu K, Takeda D, Shigeoka M, Kimoto A, Hasegawa T, Hara T, Emoto N, Akashi M.   +12 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Structures of clinical antibodies bound to IL-33 uncover two distinct epitopes underlying differential efficacy. [PDF]

MAbs
Chen J, Wang Y, Wang X.
europepmc   +1 more source

Table 1_Eosinophils and pleural macrophages counter regulate IL-33-elicited airway inflammation via the 12/15-lipoxygenase pathway.xlsx

Emi Ito (526539), Reika Hayashizaki (21104978), Takuro Hosaka (21104981), Tsuyoshi Yamane (3318771), Jun Miyata (823187), Yosuke Isobe (456507), Makoto Arita (82805)   +6 more
openalex   +1 more source

IL-33 precursor drives inflammation without engaging T1/ST2 or Th2

, 2013
Irina Luzina, Lockatell Virginia, Todd Nevins, Atamas Sergei   +3 more
openalex   +1 more source

Increased Expression of IL-33 in Severe Asthma: Evidence of Expression by Airway Smooth Muscle Cells [PDF]

, 2009
David Préfontaine, Stéphane Lajoie-Kadoch, Susan Foley, Séverine Audusseau, Ron Olivenstein, Andrew J. Halayko, Catherine Lemière, James G. Martin, Qutayba Hamid   +8 more
openalex   +1 more source