Results 361 to 370 of about 4,627,366 (384)

IL-33 sensitizes Mast Cells to PIEZO1 Stimulation Leading to Degranulation

義照 小林
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Simultaneous Investigation of sST2, IL-33, and Caspase-3 Serum Levels in Non-small Cell Lung Cancer. [PDF]

In Vivo
Akdeniz FT, Barut Z, Avşar O, Arinç S, Isbir T.   +4 more
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Auranofin Ameliorates Gouty Inflammation by Suppressing NLRP3 Activation and Neutrophil Migration via the IL-33/ST2-CXCL1 Axis. [PDF]

Cells
Yoo H, Choi A, Kim M, Gye Y, Jo H, Kwok SK, Park Y, Lee JJ.   +7 more
europepmc   +1 more source

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IL-33/ST2 axis in autoimmune disease.

Cytokine, 2022
Interleukin-33 (IL-33) is a member of the IL-1 family and plays an ambivalent role in autoimmune diseases. IL-33 signals via the ST2 receptor and drives cytokine production in mast cells, basophils, eosinophils, NK cells, and T lymphocyte cells.
Leila Shakerian, Hanieh Kolahdooz, Mitra Garousi, Vahideh Keyvani, Ramiar Kamal Kheder, Tola Abdulsattar Faraj, Esmaeil Yazdanpanah, Seyed-Alireza Esmaeili   +7 more
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Thrombin cleaves IL‐33 and modulates IL‐33‐activated allergic lung inflammation

Allergy, 2022
AbstractBackgroundOrganisms have orchestrated coagulation and immune systems. Although a link between inflammation and haemostasis has been reported in asthma, the interaction mechanism has not been completely elucidated. Here, we investigated the direct link between the mammalian immune and coagulation systems.MethodsMice were administered protease or
Yuying Huang, Xuezhen Li, Lin Zhu, Chunrong Huang, Wen Chen, Zhiyang Ling, SongLing Zhu, Xintong Feng, Chunyan Yi, Wangpeng Gu, Chenghua Yan, Jing Wang, Liyan Ma, Xiao Su, Ranran Dai, Guochao Shi, Bing Sun, Yaguang Zhang   +17 more
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Emerging Functions of IL-33 in Homeostasis and Immunity.

Annual Review of Immunology, 2022
Our understanding of the functions of the IL-1 superfamily cytokine and damage-associated molecular pattern IL-33 continues to evolve with our understanding of homeostasis and immunity.
G. Dwyer, Louise M. D’Cruz, H. Turnquist   +2 more
semanticscholar   +1 more source

IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines.

Immunity, 2005
Cytokines of the interleukin-1 (IL-1) family, such as IL-1 alpha/beta and IL-18, have important functions in host defense, immune regulation, and inflammation. Insight into their biological functions has led to novel therapeutic approaches to treat human
J. Schmitz, Alexander M. Owyang, E. Oldham, Yaoli Song, E. Murphy, T. Mcclanahan, G. Zurawski, M. Moshrefi, J. Qin, Xiaoxia Li, D. Gorman, J. Fernando Bazan, R. Kastelein, Schering-Plough Biopharma   +13 more
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The Reparative Roles of IL-33

Transplantation, 2023
When discovered in the early 2000s, interleukin-33 (IL-33) was characterized as a potent driver of type 2 immunity and implicated in parasite clearance, as well as asthma, allergy, and lung fibrosis. Yet research in other models has since revealed that IL-33 is a highly pleiotropic molecule with diverse functions.
Johnny, Bou Saba, Hēth R, Turnquist
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TSLP impairs epidermal barrier integrity by stimulating the formation of nuclear IL-33/phosphorylated STAT3 complex in human keratinocytes.

Journal of Investigative Dermatology, 2022
Atopic dermatitis (AD) is an inflammatory skin disease characterized by skin barrier dysfunction. Although Th2 cytokines downregulate the expression of epidermal barrier proteins, the signaling mechanism underlying these effects remains unclear. IL-33, a
X. Dai, J. Muto, K. Shiraishi, R. Utsunomiya, H. Mori, M. Murakami, K. Sayama   +6 more
semanticscholar   +1 more source