Results 211 to 220 of about 1,034,039 (274)

Endothelial IL-36 receptor activation promotes vascular stability to limit pathological microvessel permeability in the CNS.

Cell Rep
Fahey E, Celkova L, Frezza V, Sullivan GP, Byrne K, Watson A, Hernandez-Santana YE, Byrne K, Dalton R, Efe-Cicek H, O'Callaghan J, Delaney C, Ozaki E, Walsh PT, Martin SJ, Campbell M, Doyle SL.   +16 more
europepmc   +1 more source

Dual blockade of IL-17A and IL-36 pathways via a bispecific antibody exhibits enhanced anti-inflammatory potency. [PDF]

Front Immunol
Ma X, Zhang S, Ren X, Feng Y, Li H, Chen S, Xu J, Wang Y, Peng GY, Yan Q, Jia H, Xia S, Cui X, Chen X, Pan X, Wang S, Yu H, Wei X, Li M, Liu B, Xu J, Qian Q, Zhu X, Zhan Y, Lu L.   +24 more
europepmc   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Successful Treatment of Pediatric Generalized Pustular Psoriasis (GPP) with Spesolimab: 5 Case Reports and Evaluations of Circulating IL-36 Levels. [PDF]

J Inflamm Res
Chen Y, Wang Z, Liang Y, Shen C, Jiao L, Xiang X, Miao C, Xu Z.   +7 more
europepmc   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

IL-36 Gamma: A Novel Adjuvant Cytokine Enhancing Protective Immunity Induced by DNA Immunization with TGIST and TGNSM Against Toxoplasma gondii Infection in Mice. [PDF]

Microorganisms
Tan Y, Mu J, Chen J.
europepmc   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Floxed Il1rl2 Locus with mCherry Reporter Element Reveals Distinct Expression Patterns of the IL-36 Receptor in Barrier Tissues. [PDF]

Cells
Tongmuang N, Cai KQ, An J, Novy M, Jensen LE.   +4 more
europepmc   +1 more source

Role of IL-36 Cytokines in the Regulation of Angiogenesis Potential of Trophoblast Cells. [PDF]

Int J Mol Sci, 2020
Murrieta-Coxca JM, Gutiérrez-Samudio RN, El-Shorafa HM, Groten T, Rodríguez-Martínez S, Cancino-Diaz ME, Cancino-Diaz JC, Favaro RR, Markert UR, Morales-Prieto DM.   +9 more
europepmc   +1 more source