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Current Opinion in Pharmacology, 2012
Psoriasis is a common but severe skin disease with significant health consequences, both physical and psychological. Evidence has emerged during the past several years pointing to a key role for IL-36 in psoriasis. Overexpression of IL-36 in mouse skin leads to a disease quite similar to human plaque psoriasis, and inhibition of IL-36 in human ...
J E, Towne, J E, Sims
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Psoriasis is a common but severe skin disease with significant health consequences, both physical and psychological. Evidence has emerged during the past several years pointing to a key role for IL-36 in psoriasis. Overexpression of IL-36 in mouse skin leads to a disease quite similar to human plaque psoriasis, and inhibition of IL-36 in human ...
J E, Towne, J E, Sims
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IL-36 in chronic inflammation and cancer
Cytokine & Growth Factor Reviews, 2020IL-36 belongs to the IL-1 family of cytokines and activates target cells by binding to a specific cytokine receptor (IL-36R) followed by activation of intracellular regulators such as MAP kinases and NF-kappaB. Three subforms of IL-36, denoted IL-36alpha, IL-36beta and IL-36gamma, have been described that require N-terminal cleavage for activation ...
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IL-36 cytokines are increased in acne and hidradenitis suppurativa
Archives of Dermatological Research, 2017Interleukin (IL)-36 cytokines are new members of the IL-1 family, which include pro-inflammatory factors, IL-36α, IL-36β and IL-36γ, and a natural receptor antagonist IL-36Ra. Over recent years, much has been learned on their important functions in the regulation of immune response and, especially, on their role in many inflammatory skin diseases ...
DI CAPRIO, ROBERTA +6 more
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IL-36 cytokines regulate antiviral immunity
The Journal of Immunology, 2016Abstract Viruses may succeed as pathogens by deploying immune evasion mechanisms aimed at limiting detection by the host. If the host has developed counter strategies to ensure viral clearance is less clear. HSV-1 blocks inflammatory signaling from infected cells by preventing extracellular release of IL-1β.
Liselotte E Jensen, Katelynn A Milora
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The Diverse Roles of the IL-36 Family in Gastrointestinal Inflammation and Resolution
Inflammatory Bowel Diseases, 2020AbstractThe interleukin (IL)-36 family is a member of the IL-1 superfamily of cytokines and, in common with other IL-1 family members, has been shown to exhibit pleiotropic effects in homeostasis and inflammation. Although the important role these cytokines play in the skin has been widely reported, recent evidence suggests that IL-36 family members ...
Gemma Leon +2 more
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IL-36: An Epithelial Cytokine Important in Psoriasis
2013Interleukin-36 (IL-36) refers to three cytokines that are members of the IL-1 family. These cytokines are expressed predominantly but not exclusively by epithelial tissues. Similar to other IL-1 family cytokines, they promote inflammatory responses by activating kinases such as JNK, p38, and the IKKs, and activating transcription factors such as NFκB ...
John E. Sims +3 more
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Inflammation: IL-36 has proinflammatory effects in skin but not in joints.
Nature reviews. Rheumatology, 2014Given the known involvement of IL-36 in psoriasis it might be surprising that the latest mouse models show that inhibiting IL-36 signalling does not alter the course of inflammatory arthritis. Can we now add IL-36 to the list of inflammatory mediators that are not viable DMARD targets?
Dietrich Damien, Gabay Cem
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Modeling of the Network Mediated by IL-36 Involved in Psoriasis
2023Pathogenesis of inflammatory, chronic and common skin disease Psoriasis involves immune cells, skin cells (keratinocytes) and cytokines secreted by them. Hyperproliferation and abnormal differentiation of keratinocytes are believed to be a hallmark of it.
Sneha Pandey +4 more
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IL-36: a therapeutic target for ulcerative colitis?
Expert Opinion on Therapeutic Targets, 2022Yasmina E. Hernandez Santana +2 more
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